Fahad Mukhtar1, Paolo Boffetta2, Bashir Dabo1, Jong Y. Park3, Chi TD Tran4,
Thuan V. Tran5,6, Huong Thi-Thanh Tran5,6, Madison Whitney1, Harvey A. Risch7,
Linh C. Le4,8, Wei Zheng9, Xiao-Ou Shu9, Hung N. Luu9,10,11
1Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL; 2Tisch Cancer Institute, Icahn School of Medicine, Mount Sinai School of Medicine, New York, NY; 3Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; 4Vietnam Colorectal Cancer and Research Program, Vinmec Healthcare System, Hanoi, Vietnam; 5Vietnam National Cancer Hospital, Hanoi, Vietnam; 6Vietnam National Institute for Cancer Control, Hanoi, Vietnam; 7Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT; 8VinUniversity Project-Health Sciences, Hanoi, Vietnam; 9Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN
10Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA; 11Currently at the Division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center-Hillman Cancer Center, Pittsburgh, PA, USA
OBJECTIVE: To assess the improvement in survival of patients with lymphoma from 1990 to 2014, stratified by age, sex, and race using the SEER (Cancer and Other Diseases Epidemiology Registry) database.
STUDY DESIGN: We identified 113,788 new cases of lymphoma from nine SEER cancer registries that track lymphoma mortality. Cox regression models were used to estimate HRs and corresponding 95% confidence intervals for different time periods in groups stratified by race, age, and sex.
RESULTS: The 5-year survival rate in patients with Hodgkin lymphoma aged 20–49 years was 89%. Compared with the same age group in 1990-1994, survival rates improved significantly in 2000-2004 (HR = 0.65; 95% confidence interval: 0.54-0.78), 2005-2009 (HR = 0.46; 95% confidence interval: 0.38-0.57), and 2010-2014 (HR = 0.29; 95% confidence interval: 0.20-0.41). Hodgkin lymphoma patients aged 75–85 years had a 5-year survival rate of 37%, and in these patients, compared with 1990–1994, survival improved only from 2005 onwards (HR = 0.67; 95% confidence interval: 0.50–0.90). For non-Hodgkin lymphoma patients, survival increased in all age groups between 1990–1994 and 2010–2014. Survival after diagnosis of both Hodgkin and non-Hodgkin lymphoma improved in all races and in both sexes.
CONCLUSION: Survival in patients with lymphoma improved significantly between 1990-1994 and 2010-2014, although disease-related mortality remained higher in older age groups.
