Authors: Nguyễn Thanh Liêm (1), Trần Liên Anh (2), Triệu Thị Hồng Thái (2), Bùi Việt Anh (1)
Department of Stem Cell and Immune Cell, inmec Research Institute of Stem Cells and Gene Technology, Hanoi, Vietnam
Department of Neonatology, Vinmec International Hospital, Hanoi, Vietnam
Corresponding author: Nguyễn Thanh Liêm. E-mail: v.liemnt-ceo@vinmec.com
Journal: American Journal of Case Reports 2017; 18:1090-1094
Published date: 2017-10-12
Link: https://www.amjcaserep.com/abstract/index/idArt/905244
Background: Bronchopulmonary dysplasia (BDP) is a chronic disease and currently has no specific treatments. This study reports the successful treatment of a 30-week-old neonate with established bronchopulmonary dysplasia by bone marrow mononuclear cells (BM MNCs) transplantation.
Case report: The preterm infant with BPD requiring continuous oxygen administration for 4 months post-delivery underwent BM MNCs. Bone marrow was obtained from the patient’s iliac crests and mononuclear cells were isolated by density gradient centrifugation method. BM MNCs were delivered via endotracheal and intravenous routes. After BM MNCs transplantation, remarkable improvements were observed in oxygen saturation and lung CT as the infant was gradually weaned off oxygen supply.
Conclusion: Bone marrow mononuclear cells (BM MNCs) transplantation offers promising treatment of Bronchopulmonary dysplasia (BPD).
