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Viartril-S is a drug that works to treat and prevent degenerative joint diseases, such as spinal degeneration, back pain, arthritis, bone fractures,... The drug needs to be used properly and at the right dose. recommended dosage for optimal therapeutic effect.
1. What is Viartril S?
Viartril-s is a drug used to prevent and treat degenerative joint diseases such as periarthritis, spondyloarthritis, arthritis, atrophic fractures, back pain, subacute / chronic arthritis , osteoarthritis. In addition, Viartril-s is also used in a number of other treatment indications that are not mentioned, patients can discuss more with their doctor for detailed information.
Currently, the drug viartril s is prepared in 2 forms, including powder for oral suspension or capsules. The drug belongs to the group of treating osteoarthritis and gout. The main ingredient of Viartril-s is glucosamine sulfate, along with some other excipients such as sorbitol, aspartame, citric acid and polyethylene glycol. In each dosage form, Viartril-s will have different strengths, respectively:
Viartril s 250mg capsule. Viartril s 500mg capsules. Viartril s oral suspension powder pack 1500mg.
2. Indications and uses of Viartril S
2.1 Indications to use viartril s Viartril-s is usually prescribed by doctors for some of the following conditions:Osteoporosis, osteoarthritis. Inflammatory disease around the joints. Primary/secondary degenerative conditions, such as hip, knee, hand, shoulder, or spine osteoarthritis. The condition of atrophic bone fractures. Acute or chronic arthritis. Because viartril s is a prescription drug, so patients are only allowed to use it when prescribed by a doctor. Avoid self-medication to treat illness, as this can potentially pose many other health risks to the patient.
2.1 Uses of the drug Viartril S Pharmacodynamics
Viartril-s drug belongs to a group of pharmacological treatments, including non-steroidal anti-inflammatory drugs, anti-rheumatic drugs and anti-inflammatory drugs. The main active ingredient glucosamine sulfate in the drug is the salt form of glucosamine amino-saccharide, which acts as a normal physiological substance in the body. This active ingredient is often used in combination with sulfate radicals to help promote the biosynthesis of glycosaminoglycans of the articular cartilage matrix and hyaluronic acid of the synovial fluid.
The mechanism of action of the active ingredient glucosamine sulfate in the drug is to stimulate the synthesis of proteoglycan and glycosaminoglycan of the joints. In addition, glucosamine also has a very good anti-inflammatory ability, and helps inhibit the degeneration of articular cartilage by inhibiting interleukin 1 (IL-1) - a cytokine closely related to the pathogenesis of osteoarthritis osteochondrosis. Some studies have shown that glucosamine sulfate has an inhibitory effect on superoxide free radicals, articular cartilage-destroying enzymes (phospholipase A2 or collagenase) and cytolytic enzymes. This contributes to a mild anti-inflammatory effect for some types of osteoarthritis. In addition, a number of short and medium-term clinical studies also show that the use of glucosamine sulfate significantly improves the symptoms of osteoarthritis after only 2-3 weeks of treatment. Furthermore, the therapeutic effect of Viartril-s compared with other non-steroidal anti-inflammatory drugs or analgesics is ideal after 3 or 6 months of continuous dosing with pronounced effects lasting for 2 months. months after stopping the drug.
When treated with Viartril-s continuously for 3 years can significantly improve the symptoms of osteoarthritis and help slow down the destruction of joint structure in patients. On the other hand, the active ingredient glucosamine sulfate is also very well tolerated and rarely causes serious effects on the autonomic nervous system, central nervous system, respiratory system or cardiovascular system.
Pharmacokinetics
After taking glucosamine, this active substance will be absorbed and widely distributed throughout the body. The absolute bioavailability of the drug is usually between 20 and 30%. Following oral administration of glucosamine at repeated doses of 1500 mg/day, the peak steady-state plasma concentration of the drug was 8.9 μM (1602±425 ng/ml).
After absorption, Viartril-s will distribute mainly in the extravascular compartments. As observed, the apparent volume of distribution of the drug is 37 times greater than the total amount of water in the patient's body. Currently, there are no specific studies on the metabolic properties of the drug. In humans, the terminal plasma half-life of glucosamine sulfate is generally more than 48 hours after oral administration.
3. Dosage and usage of Viartril-s
3.1 Dosage of Viartril-S The dose of Viartril-S will be determined and adjusted appropriately for each patient's age and medical condition. The dose below is for reference only, so patients need to discuss directly with their doctor to get the correct dose.
Dosage for people > 18 years old
Take 6 capsules Viartril-s 250mg, divided dose into 3 times / day. For powder medicine for suspension, patients can take 1 pack of Viartril-s 1500mg about 1 time / day. The drug can be used to treat alone or in combination with some other drugs, typically chondroitin 1200mg/day. The duration of drug use will depend on each individual, patients should use continuously for at least 2-3 months to ensure effective treatment. Adult dose
For Viartril-s capsules: Take one 500mg capsule or 2 250mg capsules, 3 times a day. For Viartril-s powder for suspension: Take a pill pack with a dose of 1 time / day, use after meals. Pediatric Dose
There are no specific studies on the appropriate dose of Viartril-s for children. Therefore, before deciding to use this drug for children, you need to carefully consult the instructions of a specialist.
3.2 How to use Viartril-s drug Viartril-s drug is used orally, patients should take the drug about 15 minutes before meals:
For capsule medicine: Swallow the tablet whole and drink it directly with water filter / white water. For medicine in powder form for suspension: Mix the drug with a sufficient amount of water, then stir well to dissolve the drug before drinking.
4. What to do when taking an overdose or forgetting a dose of Viartril-S?
4.1 How to deal with an overdose of Viartril-S There have been no reports of accidental or intentional overdose of Viartril-S. According to the results of acute and chronic toxicity studies in animals, when using a dose 200 times the therapeutic dose of Viartril-s may not cause toxic symptoms. However, if toxicity occurs, the patient should be treated immediately for symptomatic treatment and standard supportive measures such as restoration of electrolyte balance should be used if necessary.
4.2 What to do if you miss a dose of Viartril-S If you forget to take a dose of Viartril-S, try to take it as soon as possible. However, you should skip the missed dose and take your next dose as scheduled if the time between doses is too close. Never take a double dose on your own, as this can lead to potential health risks.
5. Contraindicated to use Viartril-S in any case?
Viartril-s should not be used in the following specific cases:
Patients are allergic to glucosamine or are hypersensitive to other excipients in the drug. People who are allergic to crab/shrimp shells because the main ingredient in the drug is found in the shells of these seafood. People with symptoms of phenylketonuria because Viartril-s in powder and suspension contains aspartame. The patient has fructose intolerance due to the presence of sorbitol in Viartril-s powder for suspension. People with galactose intolerance, glucose-galactose malabsorption or lactose deficiency because Viartril-s capsules contain lactose. Do not use the drug for children, pregnant women or nursing mothers because there are no reports on the effectiveness and safety when using the drug for these subjects.
6. Some side effects when using Viartril-s
When using Viartril-s, patients may experience some of the following notable side effects:
Headache, dizziness, insomnia, somnolence. Tachycardia or peripheral edema. Diarrhea, nausea, vomiting, abdominal pain, loss of appetite, constipation, abdominal pain, heartburn. Itching, red skin rash, hives. The above list is not exhaustive of all the side effects of Viartril-s, in some cases other side effects may still occur. If the patient has any concerns about the side effects of Viartril-s, please consult or talk to your pharmacist / doctor.
7. Some other notes when using Viartril-S
7.1 Interactions of Viartril-S with Other Drugs Patients should avoid using Viartril-s with tobacco, alcohol, fermented or alcoholic beverages. These drinks or stimulants may reduce the therapeutic effect of the active ingredients and ingredients in the medicine.
In addition, when combined treatment with glucosamine sulfate with anticoagulants may increase the anticoagulant effect of coumarin. Therefore, patients need to closely control coagulation parameters when starting and ending treatment with Viartril-S. On the other hand, oral Viartril-s treatment can also increase the gastrointestinal absorption of tetracycline in patients.
7.2 What precautions should be taken while taking Viartril-S? Here are some things that patients need to be careful about while using Viartril-s:
The drug does not cause gastrointestinal disorders, so patients can be treated for a long time. The Viartril-s regimen should be repeated at approximately 6 months or less based on the patient's assessment of the medical condition. Care should be taken when deciding to administer the drug to a person who is planning to become pregnant or is pregnant. If necessary, use Viartril-s under the supervision of a specialist. The effect of Viartril-s will be effective after 1 week of use, so if the patient feels a lot of pain, he or she can take an anti-inflammatory pain reliever in the first few days of treatment. People with liver failure, hepatic coma, renal failure, myasthenia gravis or peptic ulcer should exercise caution before taking the drug. 7.3 How to store Viartril-S You should store Viartril-s at room temperature, away from light and high humidity. Never store medicine in the freezer or bathroom. Because each medicine will have a different storage method, you should carefully read the storage instructions on the package or consult your doctor.
Medicines need to be kept out of reach of children and minimize contact with family pets. For medication that has expired or needs to be discarded, you should dispose of it properly as directed by your doctor for safe disposal.
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