Uses of Piascledine 300mg

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Osteoarthritis is a chronic, relapsing disease and treatment is often accompanied by anti-inflammatory pain relievers, they have many side effects on your digestive, cardiovascular and kidney systems. That's why researchers are always looking for safer, longer-term, and more effective treatments, and Piascledine is one of them. Let's learn about Piascledine and its use Piascledine 300mg.

1. What is Piascledine?

Piascledine 300mg is a drug used to treat symptoms in bone and joint diseases with the main active ingredients: Whole unsaponified avocado and soybean oil. In which: Total unsaponifiable avocado oil is 100mg and total unsaponifiable soybean oil is 200mg
You can find piascledine on the market today in the form of capsules with a content of 300mg. The dose of piascledine is 1 tablet / time / day and you should take it with plenty of water, avoid chewing the broken tablet and should be taken in the middle of a meal.

2. Uses of Piascledine 300mg

2.1 Uses of piascledine 300mg in the treatment of musculoskeletal diseases Piascledine 300mg has a slow effect in the symptomatic treatment of osteoarthritis, especially large joints such as hip and knee joints. And also because of this slow-acting property, when starting treatment with Piascledine 300mg doctors will use it in combination with a non-steroidal anti-inflammatory drug and/or analgesic, the dose can be reduced when the Piascledine effect has been achieved. increase.
The main mechanism of action of piascledine includes:
Increases the synthesis of proteoglycans (PG), especially the high molecular weight group, with similar quality to natural PGs. Complementary effects of two components of Piascledine: chronic stimulation of PG synthesis and acute inhibition of PG degradation. Stimulates collagen synthesis by articular chondrocytes and synovial cells. The effect on collagen is due to a decrease in PGE2 synthesis by chondrocytes, a decrease in the inhibitory effect of IL-1, and inhibition of collagenase type II in joints. Stimulation of the activity of plasminogen activator inhibitor 1 (PAI-1) and TGFβ1 and TGFβ2 results in rapid recovery and protection of the extracellular matrix. In summary, the use of piascledine 300mg helps to improve the treatment of inflammatory conditions, osteoarthritis thanks to the fact that piascledine can:
Act on subchondral bone, cartilage, and synovial fluid Stimulate synthesis of joint cartilage matrix Reduce degeneration cartilage Reduces inflammatory mediators As a result, Piascledine can improve the symptoms of joint pain, making patients feel more comfortable and comfortable, and Piascledine also helps improve the body's mobility, making The joints are moved more smoothly.
2.2 Uses of piascledine 300mg in the treatment of oral diseases In near-tooth diseases, piascledine has nutritional effects to help support the treatment of periodontitis. In addition, in some documents, Piascledine is also used in the treatment of high blood pressure, menopausal symptoms, high cholesterol levels, ...

3. Piascledine 300 and any unwanted effects?

3.1 Will piascledine 300 cause an allergic reaction? The answer is yes, you should tell your doctor if you have ever had a history of allergy to the drug or any of its ingredients. In addition, during treatment with piascledine you have any symptoms of an allergic reaction such as itching, rash, redness, swelling of the face, difficulty breathing, ... stop taking the drug and contact immediately with your doctor. However, you should also rest assured because allergic reactions to piascledine 300mg are quite rare.
3.2 Does piascledine 300 have any effect on the gastrointestinal tract? You may experience digestive disorders when using piascledine such as epigastric abdominal pain, diarrhea. Data suggest that the gastrointestinal adverse effects of piascledine are higher than those of other organs, but the incidence of these adverse effects is also very low.
3.3 What effect does piascledine 300 have on the hepatobiliary system? Before taking piascledine if you have or have had liver or gallbladder disease, tell your doctor or pharmacist. Very rare hepatobiliary disorders include: elevation of transaminases, alkaline phosphatase, bilirubin and gamma-glutamyl transpeptidase.
But if you have any signs or symptoms of liver or gallbladder problems, such as: unexplained nausea, vomiting, abdominal pain, fatigue, loss of appetite, yellowing of the skin and eyes and urine dark, stop treatment and contact a doctor immediately

3.4 Does piascledine 300 have any effect on pregnant and lactating women? As with all drugs, the use of piascledine in pregnancy and lactation should be carefully considered. To date, in animal and clinical trials, there is no evidence of malformative or toxic effects on the fetus. However, should piascledine be avoided during pregnancy and lactation
3.4 Does piascledine 300 have any effect on children and adolescents under 18 years of age? Safety and effectiveness have not been proven, so Piascledine should not be used in this population.
3.5. Does piascledine 300 interact with other drugs? Before taking piascledine, tell your doctor or pharmacist if you are being treated with an anticoagulant (such as warfarin, ...)
Stop treatment and contact your doctor immediately if you experience signs and symptoms of a bleeding disorder, such as red or purple spots on the skin, spontaneous bruising or bruising.
The best way to avoid drug interactions is to write down a list of all the medicines you are taking (including prescription drugs, over-the-counter medicines, supplements and herbs) to show your doctor or pharmacist. . Do not self-medicate, stop taking or change the dosage of the drug without your doctor's approval and inform your doctor of any unwanted effects you may experience while using piascledine.

4 Some notes when using Piascledine

Store the medicine at room temperature (below 30 degrees Celsius), avoid storing it in a place with high humidity or direct light. Keep medicine out of reach of children and pets. There are no clinical data on overdose with Piascledine, but if you have any signs of an emergency after you overdose, call or go to your doctor right away. nearest health facility and remember to bring a list or record of the medications you take. When you forget to take a dose, take the next dose at the last scheduled time and use the prescribed dose as usual, absolutely do not take a double dose.

5 Piascledine 300mg and some other degenerative joint diseases

In addition to piascledine, people also use a number of other drugs in the treatment to slow down and improve the symptoms of degenerative joint diseases and each drug has a different mechanism of action:
5.1 Glucosamine sulfate Currently, Glucosamine sulfate is still It is the most widely used and effective drug in the treatment of osteoarthritis. The drug has analgesic, anti-inflammatory and stimulating effects on cartilage production, preventing the progression of the disease.
Glucosamine not only participates in the synthesis of joint cartilage, reducing the destruction of joint cartilage, but also stimulates the reproduction of bone connective tissue, reducing the process of bone calcium loss; Increased production of synovial fluid should increase viscosity, increase the lubricating capacity of synovial fluid. Since then, Glucosamine sulfate also slows down the process of joint degeneration, restores joint cartilage to help patients reduce pain and move more flexibly similar to piascledine.
5.2 Diacerein Like piascledine, Diacerein also belongs to the class of anti-rheumatic drugs. Diacerein inhibits the production and activity of substances produced by the body that are active in the destruction and catabolism of basic substances such as proteoglycan, hyaluronic acid and collagen type II - components of cartilage, synovial membranes.
5.3 hyaluronic acid hyaluronic acid is a particularly important ingredient, as an oily substance that helps lubricate cartilage, joints, ... to help parts such as joints and muscles move more flexibly.
When joints are degraded, the concentration of hyaluronic acid in osteoarthritis is often smaller than normal and its molecular weight is also lower than in normal people. Therefore, the addition of high molecular weight hyaluronic acid to the degenerative joint socket creates “additional viscosity” that actually significantly improves the condition of the joint. In addition, hyaluronic acid also inhibits cartilage degeneration and increases the synthesis of articular chondrocytes. Piascledine 300mg is a drug used to treat symptoms in bone and joint diseases. To ensure effective use and avoid side effects, patients need to strictly follow the instructions of the doctor, pharmacist.
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