This is an automatically translated article.
Article by Pharmacist Nguyen Thi Thanh Nga - Clinical Pharmacist - Faculty of Pharmacy - Vinmec Times City International Hospital
Acupan® has the active ingredient nefopam, which is a pain reliever mainly formulated as an infusion and for hospital use. Therefore, to ensure safety, patients need to strictly follow the instructions of doctors and medical staff.
1. What is Acupan®?
Acupan® has the active ingredient nefopam. This is a central analgesic but not in the opioid class, not in the same class as morphine. On the Vietnamese market, the drug is prepared in the form of an intravenous infusion and is mainly used in hospitals.
2. What are the uses of Acupan®?
The drug is often used in cases of acute pain, especially postoperative pain. Although the mechanism of Acupan® pain relief is not fully understood, it is a fast, potent, non-narcotic pain reliever. The drug has muscle relaxant, anticholinergic and sympathomimetic effects.
Medicines need to be prescribed and monitored by a doctor and medical staff, you should not self-use without a prescription. The dosage of the drug depends on the severity of your pain and also depends on your liver and kidney function. The usual dose is 20mg/time. The drug is given by slow intravenous infusion over at least 15 minutes. The dose may be repeated every 4 hours if necessary, the maximum total daily dose should not exceed 120 mg.
The drug should be diluted with common infusion solutions such as saline or isotonic to ensure the correct infusion time according to the instructions.
Thuốc Acupan được sử dụng trong các trường hợp đau cấp tính
3. Who should not use Acupan®?
Acupan is contraindicated in children under 15 years of age. The drug should not be used in patients with convulsions or a history of convulsions, patients at risk of urinary retention related to prostatic disorders, patients with angle-closure glaucoma, patients with drug-induced myocardial infarction. aggravate symptoms or be a risk factor for symptom onset in these patients.
The drug is metabolised by the liver and excreted in the urine. Therefore, the drug should be carefully considered in patients with severe renal impairment. The drug can worsen heart disease by causing an increase in heart rate, so doctors may be extra cautious in patients with heart problems. The elderly may be more sensitive to the side effects of the drug, which should be carefully considered before taking Acupan®.
Avoid using Acupan® in cases of known hypersensitivity to the drug. The drug is excreted in human milk at concentrations equal to serum drug concentrations. There are insufficient data on safety for use in pregnant and lactating women.
4. What are the possible side effects when using Acupan®?
Not all patients experience drug side effects and not all drug side effects occur in one patient.
While taking the medicine, you may feel drowsiness, nausea, vomiting, dizziness, dry mouth, urinary retention, sweating...
You should follow all instructions given by your medical staff during the treatment. time using the drug and being treated in the hospital. When the drug is used in appropriate doses and monitored by healthcare professionals, reports of adverse events are usually uncommon or mild and transient. When there is any abnormality during or after the drug infusion process, you need to immediately notify the medical staff for advice, support and timely treatment.
Very rare cases of drug poisoning. However, when used in excess, the drug can cause pupil dilation, blurred vision, convulsions, hallucinations, excitation, respiratory depression, tachycardia and other arrhythmias, even cardiac arrest, coma. passionate about.
Nefopam oral tablet is not available in Vietnam, however, in case of an oral overdose (especially when taking up to 1.5-2g of oral nefopam or more), the patient should be taken to the hospital immediately. for prompt treatment and care. Nefopam does not belong to the class of opioid analgesics such as morphine, so there is currently no similar antagonist. At the hospital, the doctor will give an emergency like a poisoning by using activated charcoal if the drug is recently taken, supporting the airways, supporting breathing, supporting circulation, monitoring vital signs, electricity. ECG and symptomatic treatment.
Người bệnh nên thông báo với bác sĩ những bất thường khi sử dụng thuốc Acupan
5. Precautions when using Acupan®?
You need to talk to your doctor and medical staff about your medical history and medication history, especially cardiovascular disease; mental disorders such as anxiety, insomnia, depression; eye disease such as active angle-closure glaucoma or symptomatic prostatic hypertrophy.
Infusion drugs are usually used for a short time, however, you need to talk to your doctor and pharmacist when you need to use other drugs during your treatment, because the drug can interact with other drugs or need to be followed. watch more closely.
You will be advised to lie down for 15 to 20 minutes after the Acupan® infusion to avoid some side effects such as nausea, vomiting, dizziness, sweating.
You need to avoid alcohol while taking the drug, because alcohol can increase the unwanted effects of the drug.
Follow the instructions of the doctor and medical staff, and at the same time, discuss with the medical staff any abnormalities and concerns for timely advice and support.
Acupan® has the active ingredient nefopam, which is a pain reliever mainly made in the form of an infusion and used in hospitals. Therefore, to ensure safety, patients need to strictly follow the instructions of doctors and medical staff.
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