What is Tramadol/Paracetamol?

This is an automatically translated article.

Tramadol/Paracetamol belongs to the group of pain relievers of moderate to severe severity. The drug is available in the form of tablets for oral use. Find out more about this drug in detail in the article below.

1. What are the effects of Tramadol + Paracetamol?

1.1 Indications Tramadol + Paracetamol includes 2 main active ingredients including tramadol and paracetamol (acetaminophen). Tramadol is an opioid pain reliever that affects the brain and changes how the body feels and responds to pain. Paracetamol is a common active ingredient used to relieve pain and reduce fever. When combined, Tramadol + Paracetamol works to relieve moderate to severe pain.
1.2 Contraindications Cases of contraindications to taking the drug:
Children under 12 years old; Post-operative treatment in children under 18 years of age; Patients with tonsillectomy or other types of surgical removal; Respiratory failure; Uncontrolled acute or severe bronchial asthma, lack of resuscitation equipment; Suspected gastrointestinal obstruction; Hypersensitivity, allergy to the components of the drug; Use MAOIs or within the last 14 days.

2. Instructions for using Tramadol + Paracetamol

Tramadol + Paracetamol can be used in the form of tablets with the content of tramadol 37.5 mg + paracetamol 325 mg (tramadol paracetamol 37.5 mg 325mg).
2.1 Method of administration and dosage How to use: Oral, can be taken with or without food. If the patient feels nauseated, the patient can take the medicine with food. To avoid nausea after taking the drug, patients should consult a doctor (can lie down for 1-2 hours, not move the head).
Dosage for adults and children over 12 years: The drug is not recommended for long-term use. Patients should only take short-term medication (up to 5 days) for acute pain relief. Dosage is 2 tablets every 4-6 hours as needed. Do not use more than 8 pills/day. In patients with severe renal impairment (creatinine clearance less than 30 ml/min), the dose should not exceed 2 tablets every 12 hours.
*Note:
The dose of the drug depends on the health status and the body's ability to respond to the drug. To reduce the risk of unwanted side effects, doctors may recommend that patients take the drug at a low dose at the beginning and then gradually increase the dose. Patients should absolutely comply with the doctor's instructions, do not increase the dose, do not take the drug for longer than the allowed time,...; Tramadol + Paracetamol pain relievers should be used as soon as possible. If you wait until the pain becomes severe to take the medicine, it may not work at its best; Do not use Tramadol + Paracetamol concurrently with other drugs containing paracetamol or tramadol; If the patient has pain (arthritis), the doctor may assign the patient a combination of Tramadol + Paracetamol with other pain relievers such as naproxen, ibuprofen,...; When stopping the drug after using it for a long time or in high doses, patients may experience withdrawal symptoms with manifestations such as difficulty sleeping, nausea, watery eyes, sweating, muscle aches, ... To avoid this situation, the doctor will appoint the patient to reduce the dose slowly before stopping the drug completely; When used for a long time, the drug Tramadol + Paracetamol may reduce the effect; There is a small risk that the drug can be addictive, especially if you have ever been addicted to alcohol or used to be addicted to this drug. Therefore, patients need to follow the doctor's instructions to reduce the risk of addiction, notify the doctor if the pain does not decrease or gets worse.
2.2 Treatment of overdose or missed dose If Tramadol + Paracetamol overdose, the patient may experience the following symptoms:
Tramadol overdose: Vomiting, coma, cardiovascular collapse, convulsions, respiratory failure breathing or respiratory arrest; Paracetamol overdose: In the first 24 hours, the patient showed signs of pallor, nausea and vomiting, abdominal pain, and loss of appetite. After about 12 - 48 hours, the patient has obvious signs of liver damage. In severe overdose, liver failure can lead to encephalopathy, coma, and even death. Therefore, when using an overdose of Tramadol + Paracetamol, the patient's family should call an ambulance or take the patient to the nearest medical center.
Missed dose: If a dose is missed, the patient should take it as soon as possible. If it is almost time for the next dose, the patient can skip the missed dose and take the next scheduled dose.

3. Side effects when using Tramadol + Paracetamol

Patients should tell their doctor if they experience common side effects of the drug such as: Diarrhea, constipation, lethargy, headache, dizziness, loss of appetite, nausea, sweating, fatigue, trouble sleeping , vomiting,...
You should go to the hospital right away if serious side effects occur such as: Chest pain, excessive sweating, difficulty going to the toilet, severe allergies (itching, difficulty breathing, hives). , chest tightness, hoarseness, wheezing or swelling of the mouth, lips, tongue, or throat), confusion, dizziness, fainting, fever, hallucinations, fast or irregular heartbeat, seizures, anxiety, sadness irritability, skin blisters, severe vomiting, diarrhea, shallow and slow breathing, severe or persistent headache, suicidal thoughts, vision changes, cyanosis, shivering, weakness, problems liver (jaundice, yellow eyes, abdominal pain, loss of appetite, dark urine,...).

4. Be careful when using Tramadol + Paracetamol

When deciding to use drugs, patients need to discuss with their doctor to weigh the benefits and risks. For Tramadol + Paracetamol, patients need to be cautious if:
Allergies: You should tell your doctor if you have ever had any allergic reaction to this medicine, other drugs or allergies to foods, preservatives. management, animals,...; Children: Safety and efficacy have not been established in children; Elderly: There are no studies on the relationship between age and the effects of the drug in the elderly. For patients with age-related heart, liver and kidney problems, the dose of Tramadol + Paracetamol should be adjusted; Pregnancy and breast-feeding: There are not enough studies to determine the risk of use in pregnant or nursing women. Therefore, this group of subjects needs to consult a doctor before taking the drug; Other health conditions: Alcoholism or history of alcoholism, breathing problems, history of depression, drug dependence (especially narcotics), history of neurological diseases, brain tumor, head injury, increased pressure in the head, kidney problems, liver problems, history of epilepsy, stomach problems, etc.

5. Tramadol + Paracetamol drug interactions

Because drug interactions can change the effectiveness of drugs or increase side effects, patients should inform their doctor about the drugs they are taking. At the same time, patients should not arbitrarily use the drug, stop or change the dose without the permission of the doctor.
Do not use Tramadol + Paracetamol with the following drugs: Naltrexone, Rasagiline, Selegiline. If you must, your doctor may consider not using this medicine or changing some of the other medicines you are taking.
Tramadol + Paracetamol should not be used with the following drugs: Certain antidepressants, MAOIs, antipsychotics, tranquilizers, other opioids and analgesics, drugs that lower the constriction threshold other jerks. If medication is required, your doctor may consider changing the dose or frequency of either medication.
Increased risk of side effects if Tramadol + Paracetamol is used with the following drugs: Acenocoumarol, Digoxin, Carbamazepine, Fosphenytoin, Perampanel, Lixisenatide, Phenytoin, Warfarin, Quinidine, Zidovudine. In the case of mandatory drug sharing, the doctor may instruct the patient to change the dosage or frequency of using one of the two drugs.
In addition, patients should consult their doctor about taking Tramadol + Paracetamol with food, alcohol or tobacco. During the period of taking the drug, the patient should not eat cabbage. In addition, alcohol increases the sedative effect of the drug, easily affecting the process of driving a car or machine. Therefore, patients should avoid using alcoholic beverages when taking Tramadol + Paracetamol.
Tramadol + Paracetamol is used to relieve acute and severe pain. Before using the drug, patients should consult their doctor, do not arbitrarily use, change the dosage to limit the risk of unwanted side effects.
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