Many gut-derived peptides have been considered as candidates for novel therapeutics for obesity and/or T2DM. However, so far, only a few have progressed to specific clinical trials.

Metabolic cardiovascular disease is the term used to describe metabolic diseases that affect the cardiovascular system. At present, metabolic cardiovascular diseases are a serious threat, directly affecting people's quality of life. Every year around the world 20 million people die from cardiovascular disease.

Given that inhibition of intestinal peptide degradation leads to DPP4 inhibitors as a novel approach to diabetes therapy, does increasing intestinal peptide secretion also open new therapeutic avenues? Furthermore, can the combination of both methods allow for even stronger glucose reduction and weight loss?

SST is a hormone produced by delta cells in the duodenum and pyloric regions of the intestines, pancreas, and brain. SST has two active forms: SST-14, which is secreted from the hypothalamus, intestines and pancreas; and SST-28, secreted almost exclusively by enterocytes.

Endogenous GLP-1 is rapidly processed by DPP4 in the gastrointestinal tract, resulting in very low blood levels of the active form GLP-1. This raises the question of how gut-derived GLP-1 can activate enough GLP-1 receptors in distant tissues to achieve its physiological function., 2011; Mulvihill et al. Encodes the GLP-1 prohormone, preproglucagon, which is also present in extraintestinal tissues.

This article aims to discuss the variety of methods currently being developed that seek to take advantage of the gut as a new therapeutic approach with the hope that we can achieve the effectiveness of these therapies. surgical intervention with less invasive and more scalable solutions in the treatment of metabolic diseases.

A novel alternative to bariatric surgery is pharmacotherapy based on intestinal peptides (Figure 2). The gut is a source of many factors, mainly peptides, that regulate intestinal motility and nutrient absorption. But intestinal peptides also function to promote other organs for the availability of nutrients and to initiate counter-regulatory responses such as satiety.

Obesity and metabolic diseases are major health problems worldwide. In 2016, obesity affected 13% of adults globally. Obesity is a risk factor for metabolic syndrome, a cluster of metabolic abnormalities, including type 2 diabetes, high blood pressure, high waist-to-hip ratio, and low HDL (good) cholesterol.

Diabetes mellitus is a heterogeneous metabolic disorder characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. Chronic hyperglycemia over a long period of time causes disturbances in carbohydrate, protein, and lipid metabolism, and damages various organs, especially the heart and blood vessels, kidneys, eyes, and nerves.

There are many factors that affect the health and well-proportioned body of men. Among them, weight is a significant factor. So, in men, what is the average weight of men and how does it affect men's health and appearance?

Carbuncles are reappearing recently. This disease can form a nest with hundreds of pimples on the back, neck and is often found in people with underlying diseases such as diabetes. So what is carbuncles and is it dangerous?