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Grandaxin 50mg drug is effective in the treatment of neuropsychiatric-related diseases, even accompanied by symptoms such as anxiety, vegetative disorders,... In addition, Grandaxin 50mg drug also helps reduce symptoms. stimulant in pre-delirium or delirium in alcohol withdrawal, myasthenia gravis... This article will help you better understand the effects and other information related to this drug.
1. The brand name of the drug grandaxin 50mg and the mechanism of action
Grandaxin 50mg medicine contains the brand name tofisopam which is known for its anti-anxiety effects and is short acting with a broad therapeutic index. The main mechanism of action of the drug is also not well known. But Tofisopam differs from the classical 1,4-benzodiazepine compounds in both structural or clinical pharmacological and pharmacological scores. Therefore, the use of grandaxin is effective in treating anxiety conditions accompanied by vegetative symptoms, or the body is tired or may suffer from a feeling of apathy.
In addition, what effect does grandaxin 50mg have? The drug does not have the usual sleep-inducing effect of the classic benzodiazepine compound, but it does not have muscle relaxant or anticonvulsant activity in its composition. In addition, the composition of the drug grandaxin 50mg is not capable of weakening the intellectual ability as well as physical strength of the patient, but the drug has mild stimulating activity. And the toxicity of Tofisopam is quite low and if there is only mild side effects. Moreover, using the drug does not show the physical or mental dependence of the patient if treated for a long time.
About the activity of Tofisopam in grandaxin 50mg when entering the body, it is quickly absorbed in the digestive system. Maximum plasma concentrations of the active substance can be reached approximately 1 to 1.5 hours later, with 50% of the active substance bound to plasma proteins. After the active substance is absorbed, the drug is extensively metabolised in the liver through the major metabolic pathway by methyl removal. At that time, about 60% of the drug will be excreted in the urine and 40% of the drug is excreted in the form of feces. The half-life of grandaxin 50mg can be extended from 6 to 8 hours.
Thuốc Grandaxin 50mg có công dụng giúp chống lo âu hoặc cơ thể mệt mỏi
2. Uses and doses of grandaxin 50mg
Grandaxin 50mg is produced in the form of white or grayish-white tablets, round, with cut edges and flat surface. In each tablet of the drug contains 50mg tofisopam along with other excipients such as potato starch, gelatin, talc, stearic acid... Grandaxin 50mg is prescribed by doctors for use in the following cases:
The neuropsychiatric and physical diseases of the disease are accompanied by symptoms such as anxiety, vegetative disorders, lack of energy or motivation or apathy or fatigue and may even show signs of of depression The drug is also effective in the treatment of pseudoangina pectoris In alcohol withdrawal syndrome, grandaxin 50mg is effective in reducing the vegetative symptoms as well as the excitability in the state of pre-delirium or coma. In addition, grandaxin 50 mg in tablet form may be used when muscle relaxants are contraindicated in conditions associated with myasthenia gravis, myopathy, and neuromuscular atrophy.
Grandaxin 50mg can be used in adults with a dose of 1 to 2 tablets each time and can be used from 1 to 3 times a day, equivalent to a strength of 50mg can be used up to 300mg per day. day. In case of occasional use can use grandaxin 50mg about 1 to 2 tablets.
During the treatment of the disease, the patient can start using the drug in the treatment at any dose appropriate for the specific case of the disease. There is usually no need to gradually increase the dose because the drug is provided in a well-tolerated form and there is no decrease in alertness when treating patients with grandaxin 50 mg.
3. Unexpected side effects when using Grandaxin 50mg
When using Grandaxin 50mg, there may be some side effects, but they are usually mild and transient. However, if high doses are used, side effects are more typical.
For the digestive system, patients experiencing side effects when using the drug will have feelings such as loss of appetite, constipation, flatulence, nausea, dry mouth, and even jaundice. due to cholestasis.
In addition, these side effects are also related to the central nervous system causing headaches or feelings of tension or insomnia or irritability or agitation. Occasionally, the patient may be confused and cause seizures in epileptic patients.
For some people may appear a skin rash in the form of heat starch and can cause itching. Or in some other cases there may be a respiratory condition such as respiratory failure.
In case the patient experiences all signs of suspected side effects when using Grandaxin 50mg, it is necessary to notify the doctor immediately so that he can find out the cause and how to fix it.
Bạn hãy thông báo cho bác sĩ những tác dụng không mong muốn khi sử dụng thuốc grandaxin gặp phải khi sử dụng
4. Notes when using grandaxin 50mg
When using the drug, the patient should note that if the following conditions occur, the drug should not be used:
The patient is hypersensitive to the active ingredient or components of the drug, or the patient has decompensated respiratory failure, or the patient is ill. have a history of sleep apnea syndrome, or the patient has a history of coma.
Pregnant women should not use the drug in the first trimester of pregnancy and in the period when breastfeeding.
Use caution when using Grandaxin 50mg for patients who are elderly, or those with mental retardation or those with impaired kidney and liver function. Because these patients are very likely to experience side effects of Grandaxin 50mg during the treatment.
When using Grandaxin 50mg, it should be noted that it should not be used with drugs that depress the central nervous system such as alcohol, or antidepressants or antihistamines or sedatives that cause sleep or antipsychotics, or opiate-like pain relievers. Because when these drugs are combined with Grandaxin 50mg, there may be an increase in unwanted side effects.
During treatment, Grandaxin 50mg should not be used for chronic psychosis or patients with fear or phobia. Using drugs in these cases can increase the risk of suicide for the patient or have agitated attitudes.
For patients with brain damage such as arteriosclerosis, using Grandaxin 50mg can cause convulsions in patients.
The drug has a depressive effect on the central nervous system if used in high doses and may cause symptoms such as vomiting, confusion, coma, respiratory failure... In this case, vomiting should not be caused when The central nervous system is clearly impaired. However, gastric lavage may be used, or activated charcoal or laxatives may be used to help prevent absorption of the drug. Alternatively, flumazenil or anexate can be used as an antagonist to limit this. However, these compounds should not be used in excessive doses. It is best for patients who are sensitive to benzodiazepines or flumazenil to avoid using these drugs.
For cases of hypotension that can be managed with additional intravenous infusion and keeping the patient in the trendelenburg position. In cases where the patient still cannot recover when performing this method, dopamine or noradrenaline can be used to help stabilize blood pressure to normal.
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