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Zepam 5 is trusted by many patients as well as doctors in the treatment of problems such as anxiety, agitation, insomnia. On the market today, there is a lot of information about Zepam 5 drug products, but it is still incomplete. To learn more about Zepam, you can refer to the following article.
1. What is Zepam 5?
Zepam 5 is a medicine to help treat anxiety, muscle spasms and convulsions (suitable). The drug also supports alcohol withdrawal and effectively fights muscle contractions. This medicine will work by calming the brain and nerves. Diazepam belongs to a class of drugs, also known as benzodiazepines
Zepam 5 contains the active ingredient diazepam, which belongs to a class of medicines called benzodiazepines. Box of 10 blisters x 10 tablets
1.1. Pharmacodynamics of Zepam 5
Diazepam is a long-acting benzodiazepine psychotropic drug. Diazepam also has a sedative effect that reduces stress, agitation, anxiety and induces sleep. In addition, diazepam will also relax muscles, anticonvulsants. The drug is used for a short time to treat anxiety, stress, as a sedative, pre-anesthetic, anticonvulsant (especially status epilepticus and convulsions due to high fever), antispasmodic and reduce alcohol withdrawal syndrome.
1.2. Pharmacokinetics of the drug Zepam 5
Absorption: Diazepam is well absorbed from the gastrointestinal tract. Peak plasma concentrations are reached 0.5 to 2 hours after oral administration. Intramuscularly, the absorption of diazepam may be slow and erratic depending on the site of injection. If injected into the deltoid muscle, the drug is usually rapidly and completely absorbed. When administered rectally, the drug is rapidly and almost completely absorbed.
Distribution: Diazepam is strongly bound to plasma proteins (95 - 99%). The volume of distribution ranges from 0.95 to 2 liters/kg, depending on age. Diazepam is lipophilic, so it will quickly penetrate into the cerebrospinal fluid. Diazepam and its major metabolite N-desmethyl diazepam cross the placenta and are excreted in human milk.
Metabolism: Diazepam is metabolized mainly in the liver and especially through the cytochrome P450 CYP 2C19 enzyme system. The metabolites, N-desmethyl diazepam (nordiazepam), temazepam and oxazepam appear in the urine as glucuronide conjugates, which are active substances. Only 20% of metabolites were detected in the urine during the first 72 hours.
Elimination: Diazepam has a biphasic elimination half-life, a rapid initial phase of distribution and a terminal elimination phase lasting 1-2 days. The active metabolites N-desmethyl diazepam, temazepam and oxazepam also have elimination half-lives of 30-100 hours, 10-20 hours and 5-15 hours, respectively. The drug is eliminated mainly via the kidneys, partly via the bile and depends on age and liver and kidney function.
2. What are the effects of Zepam 5?
For adults:
Short-term pain relief (2 to 4 weeks), which is an emotional state where you can sweat, shiver, feel nervous and have a fast heart rate and probably will alone or with insomnia (difficulty sleeping) or mental health problems Helps relax muscles and muscle spasms and cerebral palsy (a condition that affects the brain causing problems with movement) and stiffness or stiffness) CONDITION (when used in conjunction with other drugs) Patients with alcohol withdrawal Helps to relax neuro-dental patients. For children:
Helps with stress and discomfort caused by cerebral spasticity (a condition associated with disease or injury Affecting the brain or spinal cord causing weakness, Uncoordinated movements, stiffness or stiffness) Helps treat muscle spasms caused by tetanus (when taken with other medicines) Both adults and children can take Diazepam tablets before surgery to relax and induce sleep.
3. Zepam 5 . side effects
Drowsiness, dizziness, fatigue, blurred vision or unsteadiness may occur. If any of these effects persist or get worse tell your doctor or pharmacist right away. Remember that your doctor prescribes this medicine because they also judge that the benefits outweigh the risk of side effects. Many people using this drug will not have serious side effects. Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as memory problems, agitation, hallucinations, confusion, restlessness and depression), difficulty speaking, difficulty walking, muscle weakness, tremors (tremors), difficulty urinating, yellowing eyes/skin , signs of infection (such as sore throat that won't go away, fever, chills). Get medical help right away if you have any very serious side effects, including: slow/shallow breathing. A very serious allergic reaction to this medicine is usually very rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (and especially of the face/tongue/throat). , severe dizziness and trouble breathing.
4. Zepam 5 . drug interactions
Drug interactions may change the way the medicine works or increase the risk of serious side effects. This document also does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share them with your doctor and pharmacist. Do not start, stop, or change the dose of any medicine without your doctor's approval. Some products that may interact with this drug include: clozapine , fluvoxamine , orlistat , sodium oxybate . The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medicine is used with other products that can also cause drowsiness or problems. on respiration. Tell your doctor or pharmacist if you are using other products such as opioid pain relievers or cough suppressants (such as codeine, hydrocodone), alcohol, marijuana, and other medicines for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine). Check the labels on all your medicines (like allergy or cough and cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about the safest use of these products. This medicine may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory staff and all of your doctors know you are using this medicine.
5. How to use Zepam 5 effectively
5.1. How to use Zepam 5: Zepam 5 is also made in tablet form, so it should be taken orally. Please drink with a sufficient amount of filtered water (warm water). Do not break, chew and crush, but take the whole Zepam 5 tablet. To ensure it is best to read carefully the instructions for use attached to the medicine. 5.2. Dosage of the drug Zepam 5 Adults:
Help sedation, induce sleep dose: take 5-30mg/day before going to bed. Treatment of neurological diseases, mental diseases, dose: 10-20mg/time, 3 times a day. Treatment of convulsions, muscle spasms orally 10-30mg per day and divided into 3-4 times. Treatment of alcohol withdrawal syndrome orally 2-2.5 mg/time and 2-3 times daily. Epilepsy prevention treatment orally 2-2.5mg/time and twice a day. Children: by month of age:
Children over 6 months of age, dose: 1-2,5mg/time x 2-3 times/day. Children from 2 to 5 years old dose: oral dose of 0.5mg/kg/day, divided into 2-3 times/day Children from 6-11 years old: dose 0.3mg/kg/day and divided into 2- 3 times/day Children from 12 years old and above use dose 0.2mg/kg/day and divided into 2-3 times/day Or use as directed by treating doctor.. 5.3. Missed dose When you forget to take a dose, take it as soon as the patient remembers. When you miss a dose for too long and it is almost time for your next dose, skip the missed dose. Do not take 2 doses at the same time to make up for a missed dose.
5.4. Overdose and treatment Manifestations of overdose: somnolence, confusion, coma and decreased reflexes. Manage respiratory, pulse and blood pressure monitoring as in all cases of drug overdose. Gastric lavage immediately. Intravenous fluids and airway ventilation will prevent hypotension with noradrenaline or metaraminol. Dialysis is of little value. Flumazenil can be used to reverse some or all of the sedative effects of benzodiazepines.
6. Notes and cautions when using Zepam 5
Avoid driving & operating machines. Pregnant women and lactating women are not allowed to use.
Caution for patients with reduced liver and kidney function, chronic lung disease, angle-closure glaucoma or brain damage, arteriosclerosis.
Addiction is less likely to occur with short-term drug use. Withdrawal symptoms may also occur in patients receiving usual therapeutic doses and for a short time, there may be psychophysiological sequelae including depression. For patients with long-term treatment, the above symptoms are more common and need attention.
As with other benzodiazepines, extreme caution should be exercised when diazepam is used in the treatment of patients with personality disorders. Diazepam increases the effects of alcohol, affecting the ability to drive and operate machines.
Pay attention to the expiry date of Zepam 5 and do not use if the product has changed color abnormally or has expired. Users of this product should be aware of any side effects or product interactions, if any.
The medicine should be stored in a cool, dry place with a temperature not exceeding 30°C. Avoid direct sunlight and keep out of reach of children and pets.
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