Utrogestan 200 mg is a medication used to increase female hormones in cases of deficiency or other issues caused by hormonal imbalances. Please read the linked article below to learn more about the drug's effects.
1. What are the effects of Utrogestan 200mg?
Progesterone 200 mg is the main ingredient in utrogestan 200 mg.
Utrogestan contains the hormone progesterone in the form of tiny particles that can be administered orally or vaginally.
Utrogestan can help treat progesterone-deficient disorders.
Utrogestan 200 mg is used for the following conditions:
Treatment of Gynecological Diseases:
- Progesterone deficiency-related disorders include premenstrual syndrome, irregular menstruation caused by ovulation abnormalities or anovulation, benign breast disease, and perimenopause.
- Menopause: A supplement to estrogen therapy.
- Infertility, secondary infertility caused by partial or full corpus luteum failure, particularly in cases of ovulation abnormalities; augmenting the luteal period via egg donation.
Treatment in Obstetrics:
Threatened miscarriage, prevention of repeated miscarriages owing to luteal failure
Threatened preterm labor
2. Use and Dosage of Utrogestan 200 mg
Oral dosage:
- The typical amount is 200-300 mg of progesterone per day, divided into 1 to 2 doses.
- In the case of luteal failure (premenstrual syndrome, benign breast disease, irregular menstruation, premenopause): Treatment with a standard dose of roughly 10 days every cycle is typically administered from the 17th to the 26th day.
- Hormone Replacement Therapy: If estrogen therapy alone is not appropriate, progesterone is administered in combination during the final two weeks of treatment. After that all hormone replacement therapy should be discontinued for roughly a week. It is important to note that bleeding may occur throughout the medicine discontinuation period.
- In the case of a threatened premature labor: In the acute phase, administer 400 mg progesterone (2 Utrogestan tablets) every 6-8 hours, depending on the pregnant woman's clinical outcomes, followed by a maintenance dose of 200 mg/time, three times per day, until the 36th week of pregnancy.
Vaginal Dosage:
- The standard dosage is 200 mg of progesterone per day (1 Utrogestan 200 mg tablet) administered deep into the vagina. This dose may be increased based on the response of each patient.
- In the case of partial luteal phase deficit caused by ovulation abnormalities and irregular menstruation, take 200 mg of progesterone per day for 10 days per cycle, often from the 17th to the 26th day.
- In cases of infertility caused by full luteal phase deficiency: The initial dose of progesterone was 100 mg on the 13th and 14th days of the embryo transfer cycle, followed by 100 mg in the morning and evening from the 15th until the end of the 25th day of the cycle. From the 26th day onwards, and if pregnant, raise the amount to 100 mg of progesterone/day every week until you reach a maximum of 600 mg of progesterone/day, which should be divided into three doses. Maintain the high dose till day 60.
- Luteal phase supplements during IVF: Begin medication on the evening of the embryo transfer with a high dose of 600 mg of progesterone each day, divided into three doses.
- Threatened miscarriage or prevention of recurrent miscarriages caused by luteal failure: Use 200 mg to 400 mg of progesterone every day, divided into two doses, until the 12th week of pregnancy.
3. Side effects of using Utrogestan 200 mg
Utrogestan 200 mg may cause the following adverse effects:
- Common symptoms include alterations in the menstrual cycle, amenorrhea, bleeding between cycles, and headaches.
- Uncommon symptoms include drowsiness, dizziness, cholestatic jaundice, itching, and stomach problems. Patients on low-dose estrogen may experience transient sleepiness and/or dizziness. These symptoms will diminish when the Utrogestan dose is reduced or the estrogen dose is increased without impacting the treatment outcome.
- Menstrual cycle shortening and/or intermenstrual hemorrhage may occur if treatment is initiated too soon, particularly before day 15 of the cycle.
If you have any negative effects with Utrogestan 200 mg, you should stop taking medication and contact your doctor or go to the nearest medical institution for prompt treatment.
4. Notes for taking Utrogestan 200 mg
Contraindicated in cases of severe liver failure, allergies, or hypersensitivity to the active ingredient or any other component of Utrogestan 200 mg.
Overdose:
- When used vaginally, there have been no reported occurrences of overdose.
- Oral overdose might have the same effects as side effects. When the dose is reduced, the symptoms almost always go away.
- In some people, the typical dose of Utrogestan 200 mg may be too high, resulting in increased drug sensitivity or low blood estradiol levels. The following advise is for patients: Reduce the dose or take progesterone in the evening before going to bed for 10 days in a cycle if you experience temporary drowsiness or dizziness.
- In the case of spotting or abbreviated menstrual cycles, treatment should begin later in the cycle (for example, on day 19 rather than day 17).
- Premenopausal women and women on hormone replacement therapy should be tested to determine that their estradiol levels are acceptable.
Precautions for use:
Keep in mind that this medication is utilized but has no contraceptive effect.
- Take Utrogestan right away if you forget to. Do not take the missed dose, however, if you remember it right before the next dose. Instead, take the next dose as planned. Keep in mind that the person shouldn't take twice as much medicine to make up for the missed dose.
- Utrogestan should not be used to treat uterine bleeding until the cause has been determined, such as by examining the endometrium (the mucous membrane that lines the inside of the uterus).
As the risk of thromboembolism and metabolism cannot be entirely eliminated, medication should be terminated in the following cases:
Eye problems include visual loss, diplopia, and retinal vascular injury.
Venous thrombosis or thromboembolism, independent of site.
Patients with severe headaches
Patients who have a History of thrombophlebitis should be checked more thoroughly.
Note: More than half of early spontaneous abortions are caused by genetic difficulties, infections, or mechanical issues, which can result in miscarriage or preterm birth. In these circumstances, using progesterone will simply slow down the process of releasing dead eggs. Therefore, progesterone should only be utilized in cases of insufficient corpus luteum secretion.
For operating machinery or driving:
May be influenced by the medicine. Utrogestan can cause drowsiness and dizziness if taken orally, therefore exercise caution when driving or using machinery. To avoid negative effects from the medicine, take it at night.
Pregnancy: There are no contraindications to using Utrogestan during pregnancy, including the first few weeks.
Breastfeeding period: Because there is no specific information on whether progesterone is excreted in breast milk, it is advisable to avoid taking the medicine while breastfeeding.
- Drug Interactions: Combining Utrogestan with other medicines can influence progesterone metabolism, changing the effectiveness of some treatments such as:
Strong enzyme inducers include barbiturates, antiepileptic medications (phenyltoin), rifampicin, phenylbutazone, spironolactone, and griseofulvin, which all boost liver metabolism. - Some antibiotics (ampicillin, tetracycline) alter the intestinal microbiota, causing changes in the enterohepatic cycle of steroids.
- Because the interactions can differ from person to person, clinical outcomes cannot be anticipated.
- Furthermore, progestins may impair glucose absorption into cells, requiring individuals with diabetes to take more insulin and other diabetes treatments.
Storage: Do not use the drug if it has expired or exhibits indications of deterioration; keep it below 30°C and out of children's reach.
The following are the effects of Utrogestan and what to keep in mind when taking the medication. The medication is administered under the supervision of an obstetrician; do not use it without a prescription.
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