This is an automatically translated article.
Kimose is an enzyme-based anti-inflammatory drug used to reduce post-traumatic edema, anti-inflammatory or antithrombotic. In order to improve treatment effectiveness and prevent unwanted side effects, patients need to understand the effects as well as strictly follow the indications and doses of Kimose.
1. Uses of the drug Kimose
Kimose main ingredients include:
Bromelain 40mg (equivalent to 20,000 IU) Crystallized Trypsin 1g (equivalent to 2500 IU) And excipients just enough for one enteric coated tablet. Bromelain
Bromelain is known as a proteolytic enzyme, so it has the ability to break down fibrin of blood clots, help prevent blood clotting and improve blood circulation. Bromelain enzyme slows down the clotting of platelets and prevents the accumulation of plaque in the arteries, which leads to the formation of blood clots. Meanwhile, bromelain also slows the growth of prostaglandins, which are involved in many functions from blood clotting to blood reproduction. When the concentration of prostaglandins in the blood is too high, it will lead to negative effects such as swelling, inflammation and accompanying fever.
Bromelain with prostaglandin inhibition has been shown to be as effective in reducing swelling as naproprofen, ibuprofen, piroxicam or diclofenac.
Besides, bromelain can also reduce pain and improve functioning in patients with carpal tunnel syndrome. Bromelain's effect on blood-related diseases such as angina pectoris, thrombosis or relief of indigestion and stomach pain is also applied to clinical treatment.
Trypsin
Trypsin is known to be a protease secreted by the pancreas, then emptying into the small intestine through the large and small pancreatic ducts, which functions to hydrolyze proteins.
Trypsin is initially formed in an inactive form called trypsinogen, which is then activated by the enzyme enteropeptidase to become Trypsin. Trypsin catalyzes the hydrolysis of peptide bonds, which breaks down proteins into many smaller peptides. The peptides are then hydrolyzed by other digestive enzymes into amino acids. Because of this function, Trypsin is necessary for the digestive process to convert food proteins into amino acids for the body to absorb.
Applied in pharmacology, Trypsin has the ability to destroy the binding of proteins of inflammatory fluid, help reduce edema, reduce tissue destruction, anti-inflammatory in patients after surgery, injury, sprain.
2. Indications and contraindications of the drug Kimose
Kimose is indicated to treat the following cases:
Reduce edema, swelling and pain in trauma patients, who have just undergone surgery for internal hemorrhoids, external hemorrhoids, blocked hemorrhoids, after hemorrhoidectomy, anal prolapse. causing swelling, pain, redness of the skin Patients with swollen, red, painful breasts due to mastitis, blocked milk glands Patients with hematomas or thrombosis. Reduce swelling, reduce inflammation for people with sprains, injuries caused by heavy work, playing sports,... Contraindications of Kimose drug
Kimose drug should not be used in the following cases:
People who are hypersensitive to Bromelain, Trypsin or any ingredient in the medicine; Coagulation disorders or severe liver or kidney dysfunction. Stomach and duodenal ulcers Pregnant or lactating women
3. Dosage and how to use Kimose
Usage : Kimose drug is used orally. Patients should take the entire Kimose tablet, do not chew, break, or crush it because it can reduce the effectiveness of the drug. The drug should be used after meals to increase potency.
Dosage:
Starting dose: 2 tablets/time x 4 times/day Maintenance dose: 1 tablet/time x 4 times/day
4. How to handle when forgetting the drug, Kimose drug overdose
Forgotten dose:
In case the patient has just forgotten Kimose drug compared to prescribed in the prescription, it can be taken as soon as he remembers, should not forget more than 2 doses in a row. If it is time for the next dose, take it as planned. Do not change the dose without consulting your doctor. Drug overdose:
Currently, there are no studies or clinical reports on symptoms of Kimose overdose. In case Kimose overdose causes symptoms of acute poisoning, the patient should stop the drug immediately and go to a medical facility for timely treatment. Patients with drug overdose should be treated symptomatically and supportively.
5. Side effects of the drug Kimose
Patients may experience some unwanted side effects while using Kimose such as:
Digestive disorders: flatulence, abdominal pain, nausea, diarrhea or constipation. Occasionally, bleeding may occur. Stomach pain, decreased stomach acid Some patients may experience hypersensitivity reactions such as skin rash, skin redness, sweating, cold hands and feet. In some cases, patients may experience unwanted effects when using the drug. Therefore, if you experience any unusual symptoms while being treated with Kimose, you should immediately notify your doctor or nurse for immediate medical intervention.
6. Kimose drug interactions
Kimose may interact if used concurrently with the following drugs and substances:
Enzyme inhibitors such as Chloramphenicol, Cimetidine, Isoniazid...: Increases blood concentration of drugs by inhibiting drug metabolism, leading to to an increased risk of overdose and increased side effects of Kimose. Enzyme-inducing drugs such as Phenylbutazone, Phenobarbital, Rifampicin,...: stimulate drug metabolism, increase excretion of active ingredients, decrease Kimose plasma concentrations, causing decreased therapeutic efficacy. Anticoagulants: increased risk of bleeding, bleeding.
7. Notes when using Kimose
Caution in patients with impaired liver and kidney function; Patients with blood clotting disorders must consult a doctor before use; Caution should be exercised in people who drive and operate machinery, and should be monitored for neurological side effects that may cause impaired concentration; The safety of Kimose drug for pregnant women has not been established, only use the drug when the benefits outweigh the risks and it is necessary to be very cautious, follow the doctor's instructions during the treatment; Lactation: Currently, there are no studies on the effect of Kimose drug on human milk, so careful consideration should be given to use in women who are or plan to breast-feed. Above is all information about Kimose drug uses, dosage and important notes when using. Carefully read the instructions for use, understand the uses, strictly follow the instructions and instructions of the doctor will help the patient to be effective when using and avoid side effects.
Follow Vinmec International General Hospital website to get more health, nutrition and beauty information to protect the health of yourself and your loved ones in your family.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
