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Bexilan 250 is a B vitamin used in cases of neurotoxicity. So when using Bexilan 250, what should be noted to be effective and safe? Let's learn about Bexilan 250 in this article.
1. What is Bexilan 250?
Bexilan 250 is a product of USA-NIC Pharmaceutical Company, made in the form of sugar coated tablets with the active ingredient being vitamin B6 (Pyridoxine hydrochloride), content of 250 mg. Vitamin B6 is a water-soluble B vitamin, which exists in three forms: pyridoxine, pyridoxal and pyridoxamine. When entering the body, it is converted into the active forms pyridoxamine phosphate and pyridoxal phosphate. These two substances act as coenzymes in glucose, protein and lipid metabolism. In addition, pyridoxine is involved in the synthesis of hemoglobin and the synthesis of gamma aminobutyric acid (GABA) in the central nervous system.
Vitamin B6 supplementation may be necessary (due to increased need) in the following cases: Persistent fever, infection, alcoholism, burns, congestive heart failure, gastrectomy, dialysis, hyperthyroidism thyroid disease, intestinal disease (eg, diarrhea, enteritis), malabsorption related to liver - biliary disease. For patients on isoniazid therapy or for women taking oral contraceptives, daily vitamin B6 requirements are higher than normal.
Vitamin B6 deficiency can lead to iron deficiency anemia, seborrheic dermatitis, dry cracked lips, peripheral neuritis.
Pyridoxine when entering the body is stored mainly in the liver and to a lesser extent in the muscles and brain. Pyridoxine is eliminated mainly by the kidneys as metabolites.
2. Indications of the drug Bexilan 250
Bexilan 250 is indicated in the following cases:
Treatment of hereditary iron-cell anemia; Prevention and treatment of neurotoxicity caused by isoniazid or cycloserin.
3. Contraindications of Bexilan 250
Bexilan 250 is contraindicated in patients with hypersensitivity to the components of the drug.
4. Dosage and usage of Bexilan 250
Usage: Bexilan 250 is taken orally.
Dosage:
Treatment of hereditary iron-cell anemia: 1 tablet/time x 2 times/day, used for 1 to 2 months. If the patient responds, reduce the dose to 30-50mg/day. Treatment of cycloserin toxicity: 1 tablet/day
5. Undesirable effects of the drug Bexilan 250
When using Bexilan 250, patients may experience the following undesirable effects:
When using doses above 200 mg / day for more than 2 months, patients may develop severe peripheral neuropathy, progressing from unsteady gait to numb and clumsy hands. However, the condition can be reversed when the drug is stopped, sometimes leaving more or less sequelae. The rarer side effects of Bexilan 250 are nausea and vomiting. Patients should inform their doctor/pharmacist about any unwanted effects encountered while taking Bexilan 250.
6. Notes when using Bexilan 250
The use of Bexilan in doses above 200 mg for more than 30 days can cause pyridoxine dependence syndrome and withdrawal syndrome. Long-term use of Bexilan at doses above 200mg can cause neurotoxicity such as severe peripheral neuropathy and severe sensory neuropathy. In these cases, it is necessary to discontinue the drug and treat symptomatically. Use of high doses of Bexilan during pregnancy can lead to drug dependence syndrome in the neonate. A small number of cases have reported that high doses of pyridoxine can cause blocked milk ducts in lactating women. Therefore, only use Bexilan 250 for pregnant and lactating women when absolutely necessary under the guidance of a doctor. Bexilan 250 can be used for drivers and operators.
7. Drug interactions
Bexilan 250 may interact with the following drugs:
Levodopa : Bexilan 250 reduces the effect of levodopa in the treatment of Parkinson's disease, but this does not happen with combination preparations such as levodopa - carbidopa or levodopa-benserazid. Phenytoin and Phenobarbital: A typical dose of Pyridoxine can reduce blood levels of phenobarbital and phenytoin by 40-50%. Oral contraceptives: Pyridoxine may alleviate depression in women taking oral contraceptives. In addition, some drugs can increase the need for pyridoxine such as oral contraceptives, hydralazine, isoniazid, penicilamine.
The article has provided information on what Bexilan 250 has, dosage and note when using. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Bexilan 250 exactly as directed by your doctor. Store Bexilan 250 in a cool, dry place, the temperature is below 300C, avoid direct light on the medicine.
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