This is an automatically translated article.
The article was written by the Clinical Pharmacy Team, Vinmec Times City International General HospitalDomperidone (with the commonly used brand name Motilium-M, Motilium) is commonly used to relieve symptoms of vomiting and nausea in adults and children, but the drug can cause serious unwanted effects on the heart if are not used properly.
1. Domperidone's Cardiovascular Undesirable Effects
Domperidone is a specific dopamine receptor blocker, commonly prescribed for gastrointestinal disorders. The most common adverse effects when using domperidone are headache, lethargy, somnolence, etc. Recently, reports of serious adverse cardiovascular events related to domperidone have been reported. Between 1982 and November 2013, the World Health Organization (WHO) compiled 137 reports, including cases of cardiac arrhythmias and sudden cardiovascular death. A review of the authors at the University of Iowa (USA) published in 2016 showed that the risk of ventricular arrhythmias and sudden cardiac arrest increased by up to 70% in patients taking domperidone. This risk is increased in patients who are elderly (over 60 years of age), take high doses (> 30 mg/day), or are taking medications with a high potential for interactions (eg, diltiazem, verapamil, amiodarone, antibiotics). macrolide group - clarithromycin, erythromycin,...).
Tác dụng không mong muốn thường gặp nhất khi sử dụng domperidone là đau đầu, lơ mơ, buồn ngủ,...
2. Recommendations of health authorities and experts
Only the lowest effective dose of domperidone should be used for the shortest possible time to treat nausea and vomiting. The maximum duration of treatment should not exceed 1 week.Dosage:
Adults and adolescents ≥ 35 kg: 10mg dose each time. The maximum dose is 30 mg/day. Children < 12 years and adolescents < 35 kg: 0.25 mg/kg each time. The maximum dose is 0.75mg/kg/day. Patients should consult a medical professional (doctor, pharmacist) before using domperidone-containing drugs if they are taking other drugs, or they themselves have heart disease (heart failure) congestive heart failure, cardiac arrhythmia, ...), liver disease, kidney disease, the elderly,...
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