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Pruzena is a medicine that works to relieve nausea and vomiting during pregnancy, morning sickness. In addition, the drug is also used to temporarily relieve insomnia.
1. What ingredients does Pruzena have?
Pruzena is an anti-morning drug for pregnant women. This medication is available in the form of a film-coated tablet. Each Pruzena tablet contains the following ingredients:
Active ingredient:
Doxylamine succinate 10mg. Pyridoxine hydrochloride 10mg. Excipients: Starch, lactose monnohydrate, povidone, sodium edetat, methyl paraben, talc, magnesium stearate, sodium starch glycolate, hydroxypropylmethylcellulose, ponceau color - 4R,... just enough for 1 tablet.
2. When to take Pruzena?
Pruzena is used to treat some of the following symptoms:
Treatment of nausea and vomiting during pregnancy in women. Morning sickness. Temporarily used to relieve insomnia, improve health. Pruzena should not be used in subjects who are sensitive to doxylamine, pyridoxine, other antihistamines derived from ethanolamine or any of its ingredients.
3. Usage and dosage of Pruzena
3.1.Common Dosage Adults: take 2 film-coated tablets at bedtime; In severe cases or in cases of nausea/vomiting throughout the day, the dose may be increased by 1 tablet in the morning and/or afternoon. However, this dosage is for patient reference only. To get the right dose, users need to consult a doctor.
How to take the drug: Pruzena is taken orally. The main dose should be taken at bedtime to relieve symptoms in the morning, promote health.
In case of drug overdose, it will cause drowsiness. If a dose is missed, the user should take it as soon as possible. If it is almost time for the next dose, skip the missed dose and take the next scheduled dose. Do not take a double dose.
4. Notes when using Pruzena
Drugs can cause drowsiness: patients should limit jobs such as driving, operating machinery, ... until the effect of the drug on the body is known. The drug may potentiate the sedative effects of alcohol and other CNS depressants. The drug should be used with caution in patients with pyloric obstruction, urinary tract obstruction, hyperthyroidism, increased intraocular pressure, and cardiovascular disease. Be careful when drinking alcohol. Due to the anticholinergic properties of antihistamines, caution should be exercised when Pruzena is used concomitantly with other drugs to ensure safety. The drug is used for many pregnant women and women of childbearing age without increasing the rate of malformations. The drug has no direct or indirect effects on the fetus. When taking Pruzena medicine will affect the ability to drive and use machines: Patients with dizziness and other central nervous system disorders, including visual disturbances, should not drive and operate machines. hook for safety.
5. Pharmacodynamics of Pruzena
Ingredients Doxylamine succinate is an antihistamine derived from ethanolamine. Due to its sedating properties, it is used as a temporary relief from drowsiness. It is also used in combination with cough suppressants and decongestants for temporary relief of cough and cold symptoms, enhancing the effect of the drug. Structurally, doxylamine is not related to cyclic antidepressants. The ingredient doxylamine in the drug is an antihistamine with local anesthetic, antimuscarinic, anticholinergic and sedative effects. Doxylamine is combined with pyridoxine to relieve symptoms of nausea and vomiting in pregnant women.
6. Pharmacokinetics of Pruzena
Doxylamine
This ingredient is well absorbed from the gastrointestinal tract. After taking the drug, it takes 2-3 hours for the drug to reach its peak concentration. In healthy subjects, the drug has a half-life of about 10 hours. The metabolites of conjugated doxylamine are doxylamine 0 - glucuronide, N - desmethyl - doxylamine 0 - glucuronide, N - didesmethyl - doxylamine 0 - glucuronide which is excreted in urine and feces. Pyridoxine
This component of the drug is readily absorbed from the gastrointestinal tract. Vitamin B6 is accumulated by the body mainly in the liver, to a lesser extent in the muscles and brain. The total amount of vitamin B6 in the body is about 167mg. Pyridoxal and pyridoxal phosphate are the two major forms of the vitamin present in the blood, highly bound to proteins. Pyridoxine crosses the placenta, fetal plasma concentrations are 5 times higher than maternal plasma concentrations.
7. Undesirable effects of the drug Pruzena
During the use of the drug, patients may experience some unwanted side effects as follows:
Effects on the heart: causing palpitations, tachycardia. Effects on the central nervous system: causing dizziness, disorientation, somnolence, headache, paradoxical CNS stimulation. Effects on the genitourinary system: causing difficulty urinating, urinary retention. Effects on the digestive system: the drug causes anorexia, dry mucous membranes, diarrhea, constipation, epigastric pain, dry mouth. Effects on vision: making patients see blurred, double vision. The main undesirable effect of the drug is drowsiness due to the presence of doxylamine succinate. Other side effects include: gastrointestinal disturbances, blurred vision, ringing in the ears, irritability, euphoria or weakness, loss of appetite, indigestion, headache,... When using high doses of the drug, it can cause seizures. . Allergies and anaphylaxis, agranulocytosis, and hemolytic anemia may occur. Doxylamine succinate may potentiate the effects of atropine and tricyclic antidepressants. The drug also enhances the sedative effect of CNS depressants such as alcohol, barbiturates, hypnotics, narcotic analgesics and sedatives. Patients need to inform the doctor about the unwanted effects encountered when taking the drug for guidance and appropriate treatment.
8. What drugs and foods should be avoided while using Pruzena?
Anticholinergic drugs: When using Pruzena together with narcotic analgesics, casphenothiazines and other psychiatric drugs, tricyclic antidepressants, quinidine and some antiarrhythmic drugs, antihistamines, .. Central and/or peripheral anticholinergic syndrome may occur. Cholinergic Drugs: Drugs with high anticholinergic activity may antagonize the therapeutic effects of cholinergic drugs, including drugs such as donepezil, rivastigmine and acrine. Central nervous system depressants: Concomitant use of Pruzena with CNS depressants may increase the sedative effect. Therefore, when using these drugs at the same time, it is necessary to carefully monitor the sedative effect. Interaction with alcohol: Patients should avoid taking the drug with alcohol, because it increases central nervous system depression. Treatment with isoniazid causes pyridoxine deficiency. Oral contraceptives reduce pyridoxal phosphate levels in some women. The pyridoxine component stimulates the production of dopamine from levodopa in peripheral tissues. Thus, reducing the concentration of dopamine in the brain, nullifying the treatment of Parkinson's disease. Pruzena should be stored in a dry place, away from direct light and at a temperature not exceeding 300C. Keep medicine out of reach of children. Medicines used must have the expiry date printed on the package of the medicine. Never use the medicine after the expiry date has passed.
Pruzena is a very effective anti-morning drug for pregnant women. In addition, the drug also works to temporarily relieve insomnia. However, the drug can cause many bad effects for the user, affecting the quality of work because the drug affects the central nervous system. At the same time, it is necessary to be careful when using the drug together with other drugs and some foods so as not to affect the treatment process.
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