Artrodar: Uses, dosages and side effects

This is an automatically translated article.

The article was written by Pharmacist Nguyen Thi Bich Phuong - Pharmacy Department of Vinmec Ha Long International General Hospital.
Diacerein is a new drug in the anti-osteoarthritis group indicated for the symptomatic treatment of patients with osteoarthritis of the hip or knee, with slow action.

1. Composition and uses of Artrodar

Artrodar has the active ingredient diacerein, which belongs to the group of non-steroidal anti-inflammatory and anti-rheumatic drugs. The drug is prepared in the form of Artrodar capsules with a strength of 50mg.

2. Dosage, how to use Artrodar

Dosage recommendations are as follows:
Adults: Because the drug can cause loose stools or diarrhea, it is recommended to start diacerein treatment with a dose of 50mg/day (corresponding to 1 tablet/day), taking the drug with meals evening for the first 2-4 weeks. Then the dose can be increased to 50mg/time x 2 times/day, taken with meals (1 tablet in the morning, 1 tablet in the evening). The drug should be swallowed whole (without opening the capsule) with a glass of water. Because the drug has a slow onset of action and beneficial effects are seen after the first 2-4 weeks, the doctor may prescribe a combination of non-steroidal anti-inflammatory drugs or other pain relievers.

3. Some cases should not take the drug and the note when using

Do not use the drug for the following subjects: Patients with hypersensitivity to any ingredient of the drug. Have liver disease or a history of liver disease. History of severe diarrhea, dehydration, and hypokalemia requiring hospitalization. Care should be taken when using the drug in the following subjects: Patients with previous intestinal disorders, especially irritable colon, need to weigh the benefits and risks when using the drug. Reduce dose in patients with renal impairment. Not recommended for use in patients over 65 years of age. Because there are no studies in subjects under 15 years of age, it is not prescribed to children in this group. On diuretics due to increased risk of dehydration and hypokalemia. Taking cardiac glycosides (digoxin, digitoxin) due to increased risk of arrhythmias. Taking laxatives. Pregnant and lactating women should not take the drug.

4. Artrodar side effects

Very common: Diarrhea, abdominal pain. Possible flatulence, increased intestinal motility These effects are common in the first few days of treatment and may decrease with continued use of the drug. Some cases of severe diarrhea complicated by dehydration and electrolyte disturbances require discontinuation of the drug and immediate medical attention. Some other side effects: Increased liver enzymes, itching, skin rash, eczema, dark yellow urine.

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