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Aceclofenac is commonly used in the treatment of osteoarthritis, ankylosing spondylitis, and rheumatoid arthritis. The drug is taken orally during or after meals with adequate amounts of water.1. What is Aceclofenac?
Aceclofenac has the main ingredient Aceclofenac 100mg, which belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs).Aceclofenac blocks the production of prostaglandins, which are released at the site of injury, tissue damage, and immune responses. Prostaglandins have an important role in both the body's inflammatory response and in stimulating bone resorption.
Aceclofenac 100mg is indicated for pain relief and anti-inflammatory in the following cases:
Osteoarthritis; Rheumatoid arthritis ; Ankylosing spondylitis . Do not use Aceclofenac 100mg in the following cases:
People who are sensitive to Aceclofenac or any of its ingredients; Persons with a history of active peptic ulcer or suspected peptic ulcer or bleeding; Patients with moderate to severe renal impairment.
2. Dosage and how to use Aceclofenac 100mg
Aceclofenac medicine 100mg is used orally. Swallow the tablet whole with a sufficient amount of water. It is best to drink during or after eating.
The recommended dose of Aceclofenac for adults is 200mg (2 tablets) per day, divided into 2 times, 100mg each time, one tablet in the morning and one in the evening.
There are no clinical data on the use of Aceclofenac in children, so it is not recommended for use in children under 18 years of age.
Aceclofenac dosage should be reduced in patients with hepatic impairment and the recommended starting dose is 100 mg daily.
3. Side effects of the drug Aceclofenac 100mg
Common side effects of Aceclofenac include:
Dizziness; Indigestion, abdominal pain, nausea, diarrhea; Increase liver enzymes. Less common side effects of Aceclofenac include:
Flatulence, gastritis, constipation, vomiting, mouth ulcers; Itching, rash, dermatitis, urticaria; Increased blood urea, increased blood creatinine. Rare side effects of Aceclofenac include:
Anemia; Anaphylactic reactions (including shock), hypersensitivity; Visual disturbances; Shortness of breath; Black stools; Facial swelling.
4. Aceclofenac interaction with other drugs
Aceclofenac can interact with the following drugs when used simultaneously:
Avoid concomitant use of Aceclofenac with other NSAIDs because of possible increased risk of side effects; Antihypertensive drugs: Aceclofenac reduces the antihypertensive effect of these drugs; Diuretics, Cyclosporin, Tacrolimus: Aceclofenac increases the risk of nephrotoxicity; Cardiac Glycosides: Aceclofenac may increase plasma glycosides and worsen heart failure, reduce glomerular filtration rate; Lithium: Aceclofenac reduces the elimination of Lithium; Methotrexate: Aceclofenac and Methotrexate should be used with caution within 24 hours because Aceclofenac may increase plasma concentrations of methotrexate, leading to increased toxicity; Mifepriston: Aceclofenac should not be taken for 8-12 days after taking Mifepriston because Aceclofenac may reduce the effect of Mifepriston; Corticosteroids: Using Aceclofenac with Corticosteroids increases the risk of gastrointestinal ulcers or bleeding; Anticoagulants: Aceclofenac may increase the effect of anticoagulants; Quinolone antibiotics: Aceclofenac may increase the risk of seizures when combined with Quinolone antibiotics; Antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs) when used with Aceclofenac increase the risk of gastrointestinal bleeding. Concomitant administration of zidovudine with aceclofenac increases the risk of hematologic toxicity. Antidiabetic drugs: When using Aceclofenac, you should consider to adjust the dose of drugs that lower blood sugar. Aceclofenac is indicated for the relief of pain and inflammation caused by osteoarthritis, rheumatoid arthritis or ankylosing spondylitis. The drug can cause side effects, so patients need to use it under the guidance of the treating doctor.
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