What is the effect of Arcoxia?

1. What is Arcoxia?

Arcoxia's main ingredient is Etoricoxib - a selective COX-2 inhibitor, which belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). Arcoxia is formulated in various strengths such as: 30mg, 60mg, 90mg or 120mg.

2. What are the effects of Arcoxia?

What does Arcoxia treat? Arcoxia with the main ingredient Etoricoxib is often prescribed to treat some symptoms of diseases related to joints and bones such as helping to reduce pain and swelling (inflammation) in joints and muscles. More specifically, the drug is prescribed to treat:

• Acute and chronic conditions of osteoarthritis (OA) and rheumatoid arthritis (RA);
• Ankylosing spondylitis;
• Acute gouty arthritis;
• Used to relieve pain in acute pain such as primary dysmenorrhea, moderate pain before or after dental surgery.

3. Dosage of Arcoxia

Information on dosage of Arcoxia cannot replace the advice of medical professionals, so patients should consult a doctor or pharmacist before using Arcoxia.

3.1. Dosage of Arcoxia for adults

• Osteoarthritis, osteoarthritis: use Arcoxia 30mg or use no more than 60 mg of Arcoxia once a day;
• Rheumatoid arthritis, ankylosing spondylitis: use Arcoxia up to 90mg, once a day;
• For moderate pain relief after dental surgery: use Arcoxia up to 90mg, once a day, for a maximum of 3 days;
• Acute gouty arthritis: use Arcoxia up to 120 mg once a day, for a maximum of 8 days;
• Acute pain relief, primary dysmenorrhea relief: use Arcoxia at no more than 120 mg, once a day, for a maximum of 8 days.

Some notes when using Arcoxia on special subjects:

• Elderly people, regardless of gender or race, do not need to adjust the dose of Arcoxia;
• Hepatic failure with a Child-Pugh score of 5-6 should use Arcoxia at no more than 60 mg once a day;
• Hepatic failure with a Child-Pugh score of 7-9 should reduce the dose of Arcoxia, using no more than 60 mg every 2 days, can use 30 mg of Arcoxia once a day;
• For patients with renal failure with ClCr ≥ 30mL/min, there is no need to adjust the dose of Arcoxia.

3.2. Dosage of Arcoxia for children

The dosage of Arcoxia for children has not been studied and determined, so consult your doctor before giving Arcoxia to your child.

4. CContraindications of Arcoxia
Arcoxia is contraindicated in

People who are sensitive to the ingredients of the drug;
People with a history of asthma, hives, aspirin allergy or NSAIDs;
Patients with congestive heart failure (NYHA II-IV);
Patients with persistent hypertension > 140/90mmHg that is not fully controlled;
Ischemic heart disease;
Peripheral artery disease and/or cerebrovascular disease are identified (including patients who have recently undergone coronary artery bypass grafting or angioplasty);
Patients with Child-Pugh ≥ 10 or serum albumin < 25g/L;
People with active gastric-duodenal ulcers, gastrointestinal bleeding;
Patients with severe progressive kidney disease with ClCr < 30mL/min.
Do not use Arcoxia in combination with other NSAIDs.

5. Side effects of Arcoxia

During the use of Arcoxia, patients may experience some side effects such as:

• Arcoxia causes thrombocytopenia;
• Hypersensitivity reactions, anaphylactic or pseudo-anaphylactic reactions, including shock;
• Hyperkalemia;
• Anxiety, insomnia, hallucinations, depression, restlessness...;
• Taste disturbances;
• Blurred vision;
• Congestive heart failure, palpitations/palpitations, angina, tachycardia;
• Paralytic hypertension;
• Bronchospasm;
• Abdominal pain;
• Mouth ulcers, gastrointestinal ulcers (stomach perforation, bleeding, vomiting, diarrhea...);
• Hepatitis, jaundice, increased liver enzymes AST/ALT;
• Angioedema, itching, rash;
• Stevens-Johnson syndrome;
• Toxic epidermal necrolysis...

Not all patients using Arcoxia will experience the above side effects or other side effects not mentioned may appear. Therefore, if you have any questions about the side effects of Arcoxia, please consult your doctor or pharmacist.

6. Notes when using Arcoxia

The patient's cardiovascular risk will increase with the dose and duration of use of selective COX-2 inhibitors, so Arcoxia should only be used for the shortest time, using the lowest effective dose.

The selective COX-2 inhibitor Etoricoxib in Arcoxia cannot replace Aspirin in the prevention of cardiovascular disease because Arcoxia has no effect on platelets.

Use Arcoxia with caution in: patients with clear cardiovascular risk (hypertension, hyperlipidemia, diabetes, smoking, concomitant use with acetylsalicylic acid), patients with significant dehydration (rehydration is required before using Arcoxia), patients with a history of perforation - ulcers and gastrointestinal bleeding, people over 65 years old, patients who have had acute asthma attacks, often have urticaria, rhinitis previously due to the use of salicylates or non-selective cyclooxygenase inhibitors, people who are being treated for infectious diseases....

When using Arcoxia, it is necessary to monitor the condition of water retention, edema, hypertension in people who already have water retention, hypertension, heart failure.

Monitor renal function in patients using Arcoxia with impaired renal function, decompensated heart failure, significant cirrhosis before taking the drug.

For pregnant women, Arcoxia should only be used during the first two trimesters of pregnancy if the benefits of Arcoxia outweigh the risks;

For women who are breastfeeding, Arcoxia should be discontinued or breastfeeding should be discontinued while using the drug

7. Interactions of Arcoxia

Arcoxia can interact with some drugs, changing the mechanism of action of the drugs used together or increasing the side effects of the drug. Therefore, before using Arcoxia, tell the medical staff all the drugs the patient is taking, including prescription and non-prescription drugs. Some drugs that can interact with Arcoxia:

• Anticoagulant Warfarin;
• Antibiotic Rifampicin;
• Diuretics;
• ACE inhibitors;
• Angiotensin receptor blockers;
• Lithium in the treatment of depression
• Contraceptives;
• Hormone replacement therapy;
• Immune system suppressant Methotrexate.

Arcoxia is effective in reducing pain and inflammation of the musculoskeletal system. However, when not used properly, the drug can cause unwanted side effects. Therefore, patients need to be careful during use.

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