What is Diacerein 50 mg used for?

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1. What is Diacerein 50 mg?

Diacerein belongs to a class of non-steroidal anti-inflammatory drugs used to relieve pain and swelling associated with osteoarthritis. The drug is prepared in the form of hard capsules with a strength of 50 mg.

2. Uses of Diacerein 50 mg

2.1. Pharmacodynamics Diacerein drug is often indicated in the treatment of degenerative joint diseases due to its anti-inflammatory action, because the drug does not inhibit Prostaglandin synthesis, which is well tolerated by the body in the stomach.
The mechanism of action of Diacerein brand-name drug is because the drug has the ability to affect both the anabolic and catabolic processes of chondrocytes and reduce proinflammatory factors. Statistical results of several in-vivo studies show that Diacerein and Rhein - an active metabolite, inhibit the production and activity of the pro-inflammatory and pro-catabolic cytokine IL-1b, in both superficial and deep layers of cartilage, even the synovial membrane. Simultaneously, it stimulates the production of transforming growth factors (TGF-b) and components of the extracellular matrix such as aggrecan, proteoglycan, hyaluronic acid and type II colloid. In addition, Diacerein showed macrophage migration and inhibition of phagocytosis. Animal studies with osteoarthritis have shown that Diacerein consistently reduces cartilage degeneration compared with untreated groups. Clinical studies have shown a significant reduction in pain and as well as an improvement in joint function compared to those given a placebo after 1 month of treatment with Diacerein.
Many statistics on the beneficial effects of Diacerein treatment after stopping the drug persist for at least 2 months.

2.2. Pharmacokinetics At a dose of 50 mg twice a day, before entering the systemic circulation, Diacerein passes through the liver and is completely deacetylated to rhein (an anthraquinone metabolite of rhein anthrone and senna glycosides, with active effects of rhein anthrone and senna glycosides. hepatoprotective). This substance is conjugated sulpho, Rhein is eliminated about 20% by the kidney or conjugated in the liver to rhein sulfate (accounting for 20%) and rhein glucuronide (accounting for 60%), these substances are eliminated mainly by the kidneys. When doses of 50 mg to 200 mg of Diacerein were administered as a single dose, all pharmacokinetic parameters were independent of dose. Protein binding is very high (99%), this is mainly due to the strong binding affinity for albumin. The half-life of rhein is about 4.5 hours. Peak plasma concentrations occur at about 2.5 hours.
Taking Diacerein with meals increases bioavailability. The total amount of drug excreted in the urine is about 30%. About 80% of rhein is excreted in the urine as sulpho-glucurose conjugates and about 20% as unchanged rhein. After repeated dosing (50 mg twice daily), Diacerein showed slight accumulation.
The effects of Diacerein were similar in young, healthy subjects selected for the trial and in elderly subjects with normal renal function when given a single (50 mg) or repeated dose (25 or 75 mg twice) everyday). Concentration values ​​are reached after the 3rd dose of the day, the mean half-life is then in the range of 7 to 8 hours.
In patients with severe renal impairment (creatinine clearance less than 30 ml/min), AUC and half-life were doubled, urinary excretion halved.
When taking Diacerein with a main meal will interfere with absorption into the circulatory system but increase the amount of drug absorbed by 25%.

2.3. Contraindications of the drug Diacerein 50 mg Diacerein should not be used in patients who are hypersensitive to the drug, its excipients or who have a history of hypersensitivity to anthraquinone derivatives.
2.4. Diacerein 50 mg side effects Rapid increase in intestinal transit time and abdominal pain are the most common side effects during treatment with Diacerein. These symptoms may appear within the first few days of treatment and in most cases, however, they resolve on their own with continued treatment. In addition, patients also experience some symptoms such as:
Diarrhea Stomach pain, abdominal pain, bloating Nausea, vomiting Hepatitis Hepatitis Yellowing of the skin and eyes Increased levels of liver enzymes Allergic skin reactions such as itching, rash, eczema Taking Diacerein can sometimes make urine darker yellow. This is typical of the type of compound present in the drug and is of no clinical significance. Inform your doctor about any unwanted effects encountered when using the drug other than the above effects.
2.5. Interactions with other drugs Drugs that may interact with Diacerein include:
Aluminum hydroxide, magnesium hydroxide or calcium-based antacids. Antibiotics (eg, amoxicillin/clavulanic acid) and/or chemotherapy because of the potential for increased risk of intestinal events. Increased risk of dehydration and hypokalemia when used with diuretics. Concomitant use with cardiac glycosides such as digitoxin or digoxin increases the risk of cardiac arrhythmias. If these substances are needed, they should be taken at a different time (more than 2 hours) after taking Diacerein.

3. How to use Diacerein 50 mg

Take medicine with filtered water with meals:
3.1. Dosage and administration Dosage and duration of drug use for each specific patient as prescribed by the treating doctor.
Usual dose: 1 tablet x 2 times/day after 2 main meals for a period of time as prescribed by the doctor. Diacerein may rapidly increase the time it takes for food to pass through the intestines during the first 2 weeks of treatment. Therefore, patients should start treatment with 1 tablet/day and take it after dinner, during which 2 weeks the dose can be increased to 2 tablets/day. Beneficial changes will be observed after 2 to 4 weeks of treatment, so it is important to encourage patients not to discontinue treatment, before the effects of the drug are clearly seen. May be combined with an analgesic or non-steroidal anti-inflammatory drug for the first 2 to 4 weeks of treatment. Because, Diacerein has a slow onset of action and is very well tolerated by the gastrointestinal tract.

4. Notes when using Diacerein 50 mg

Currently, there are no clinical studies in children under 15 years of age. Therefore, Diacerein should not be prescribed to children in this age group. Diacerein should not be used concurrently with laxatives, as acute diarrhea may occur. Do not use Diacerein in pregnancy In addition, Diacerein should not be prescribed to women who are breastfeeding, as it has been reported that small amounts of Diacerein derivatives pass into breast milk. Have regular monitoring, blood tests, liver function tests, and regular urine tests while taking this medicine. Patients with a history of liver disease, kidney disease or previous episodes of bowel disorders (eg, irritable bowel syndrome) should inform their doctor before taking this medicine. Diacerein is a non-steroidal anti-inflammatory drug used to relieve pain and swelling associated with osteoarthritis. . To ensure the effectiveness of treatment and avoid side effects, patients need to take medicine according to prescription or consult a doctor, pharmacist for advice.
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