Clinical and laboratory manifestations of acute lymphoblastic leukemia are variable. Sometimes symptoms can be insidious or acute. Therefore, when seeing abnormal signs, patients need to go to medical facilities for examination and treatment.

Lymphocytic leukemia is a dangerous disease, the treatment is still difficult at present. Optimal patient management requires careful attention to supportive care including direct treatment or prevention of infectious/metabolic complications and administration of irradiated blood products.

Acute lymphoblastic leukemia (ALL) is a malignant proliferative disease resulting from the accumulation of multistep mutations from a single lymphoid progenitor cell at one of several different developmental stages. Let's learn more about this disease in the article below.

In acute lymphoblastic leukemia, marrow examination is recommended for the diagnosis of this disease because approximately 10% of patients do not have circulating blasts at the time of diagnosis and the high density of myeloid cells favors the study. save genes.

Initiation and progression of acute lymphoblastic leukemia (ALL) result from successful mutations that induce alterations in cellular function, including increased self-renewal capacity, escape from normal proliferative control, Stops differentiation and increases resistance to cell death signaling (apoptosis). Disorders related to DNA repair may play an important role. Environmental factors such as ionizing radiation and carcinogenic chemicals are clearly associated with some patients with ALL. In most cases, however, no causative factor is evident. According to resonance theory, the process of leukaemia reflects the interaction between individual susceptibility and environmental factors.