What is Erdosteine ​​300mg?

This is an automatically translated article.


Erdosteine ​​300mg is used to treat acute cough symptoms in chronic bronchitis thanks to its mucus-clearing effect, thereby making it easier for patients to cough. So what is Erdosteine ​​300mg and how is it used?

1. What is Erdosteine ​​300mg?

What is Erdosteine? The composition of the hard capsule erdosteine ​​300mg contains the active ingredient erdosteine ​​300mg and excipients such as: Microcrystalline cellulose, Povidone K-30, Magnesium stearate...
Erdosteine ​​300mg is a mucolytic drug indicated for to dilute sputum in cases of acute and chronic respiratory diseases. Erdosteine ​​300mg is used only with a doctor's prescription.
Erdosteine ​​300mg is used with a dosage of 1 tablet / time, 2-3 times / day. When taking Erdosteine ​​300mg, patients should swallow the tablet whole with a glass of water, before or after eating.

2. Contraindications of erdosteine ​​300mg


Erdosteine ​​300mg is contraindicated in the following cases:
Hypersensitivity to any ingredient in erdosteine ​​300mg; Patients with cirrhosis of the liver, deficiency of the enzyme cystathionine-synthase; Severe renal impairment with creatinine clearance < 25ml/min; Pregnant women and lactating women should not take erdosteine ​​300mg (due to insufficient data on safety).

Erdosteine 300mg được dùng với liều lượng 1 viên/1 lần, 2 - 3 lần/ngày
Erdosteine 300mg được dùng với liều lượng 1 viên/1 lần, 2 - 3 lần/ngày

3. Note when using erdosteine ​​300mg


The following cases need extreme caution when using erdosteine ​​300mg :
Patient is suffering from stomach ulcer ; People with kidney and liver disease; Caution should be exercised when erdosteine ​​300mg is used in patients under 18 years of age.

4. What are the side effects of erdosteine ​​300mg?


The rare adverse effects (incidence less than 0.01% of total users) of erdosteine ​​300mg are:
Stomach pain; Shortness of breath; A cough; Diarrhea; Eczema; Headache; Vomit; Skin rash; Changes in taste ... Due to the side effects of headache and dizziness, erdosteine ​​300mg should be used with caution when patients need to perform tasks requiring alertness such as driving and operating machinery. . For patients taking more than the recommended dose (900mg of erdosteine/day) may experience sweating, dizziness and flushing. Gastric lavage should be performed within 1 hour of an overdose of erdosteine ​​300 mg, after which the patient should be closely monitored.

Đau dạ dày là tác dụng phụ của thuốc erdosteine 300mg
Đau dạ dày là tác dụng phụ của thuốc erdosteine 300mg

5. Interaction of erdosteine ​​300mg with other drugs


There are no reports of interactions of erdosteine ​​300mg with other drugs. Clinically, erdosteine ​​300mg can be combined with antibiotics, bronchodilators (Theophylline...), β2-adrenergic receptor stimulants, cough suppressants...

6. Mechanism of action of erdosteine


Erdosteine ​​is a derivative of mercapto-amino acid, exists in the form of thiolactone, this is a prodrug that, after entering the body, will be converted into an active form and give mucolytic effects. Erdosteine ​​has the effect of stabilizing mucus secretion, thinning sputum, making it easier for patients to spit out sputum (thanks to the free thiol groups in the Erdosteine ​​metabolite, which will cleave disulfide bridges of bronchial mucoproteins). Erdosteine ​​is an active ingredient with bronchoprotective effects, protecting the enzyme α1-antitrypsin by increasing the amount of IgA antibodies in the blood, increasing the ability to fight bacteria. In addition, this free thiol group of Erdosteine ​​is also capable of inactivating oxidants, especially the inactivation of free radicals.
The advantage of the drug Erdosteine ​​300mg compared to other drugs of the thiol group is that it is less irritating to the stomach because the thiol group (SH) in the erdosteine ​​molecule has been blocked by other groups.
After entering the body Erdosteine ​​is rapidly absorbed after oral administration, about 64.5% of the amount of Erdosteine ​​will be bound to plasma proteins. Erdosteine ​​is eliminated mainly in the urine as a sulfate conjugate. Food has little effect on the absorption, metabolism and excretion of erdosteine ​​300mg. Accumulation of erdosteine ​​and its metabolites with repeated dosing has not been adequately demonstrated.
Store erdosteine ​​300mg at room temperature, away from moisture, protect from light and do not store erdosteine ​​300mg in the bathroom or in the freezer compartment. Carefully read the instructions for storing erdosteine ​​300mg on the packaging or ask your pharmacist to keep erdosteine ​​300mg out of the reach of children and pets. Before using erdosteine ​​need to carefully weigh the risks and benefits, consult your doctor for detailed information before using erdosteine ​​300mg.
Erdosteine ​​300mg medicine is used for symptomatic treatment of acute cough in chronic bronchitis. To ensure the effectiveness of treatment, patients need to take medicine according to prescription or consult a doctor or pharmacist.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.

Share
Patients Stories