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Erdosteine 300mg is used to treat acute cough symptoms in chronic bronchitis thanks to its mucus-clearing effect, thereby making it easier for patients to cough. So what is Erdosteine 300mg and how is it used?
1. What is Erdosteine 300mg?
What is Erdosteine? The composition of the hard capsule erdosteine 300mg contains the active ingredient erdosteine 300mg and excipients such as: Microcrystalline cellulose, Povidone K-30, Magnesium stearate...Erdosteine 300mg is a mucolytic drug indicated for to dilute sputum in cases of acute and chronic respiratory diseases. Erdosteine 300mg is used only with a doctor's prescription.
Erdosteine 300mg is used with a dosage of 1 tablet / time, 2-3 times / day. When taking Erdosteine 300mg, patients should swallow the tablet whole with a glass of water, before or after eating.
2. Contraindications of erdosteine 300mg
Erdosteine 300mg is contraindicated in the following cases:
Hypersensitivity to any ingredient in erdosteine 300mg; Patients with cirrhosis of the liver, deficiency of the enzyme cystathionine-synthase; Severe renal impairment with creatinine clearance < 25ml/min; Pregnant women and lactating women should not take erdosteine 300mg (due to insufficient data on safety).
Erdosteine 300mg được dùng với liều lượng 1 viên/1 lần, 2 - 3 lần/ngày
3. Note when using erdosteine 300mg
The following cases need extreme caution when using erdosteine 300mg :
Patient is suffering from stomach ulcer ; People with kidney and liver disease; Caution should be exercised when erdosteine 300mg is used in patients under 18 years of age.
4. What are the side effects of erdosteine 300mg?
The rare adverse effects (incidence less than 0.01% of total users) of erdosteine 300mg are:
Stomach pain; Shortness of breath; A cough; Diarrhea; Eczema; Headache; Vomit; Skin rash; Changes in taste ... Due to the side effects of headache and dizziness, erdosteine 300mg should be used with caution when patients need to perform tasks requiring alertness such as driving and operating machinery. . For patients taking more than the recommended dose (900mg of erdosteine/day) may experience sweating, dizziness and flushing. Gastric lavage should be performed within 1 hour of an overdose of erdosteine 300 mg, after which the patient should be closely monitored.
Đau dạ dày là tác dụng phụ của thuốc erdosteine 300mg
5. Interaction of erdosteine 300mg with other drugs
There are no reports of interactions of erdosteine 300mg with other drugs. Clinically, erdosteine 300mg can be combined with antibiotics, bronchodilators (Theophylline...), β2-adrenergic receptor stimulants, cough suppressants...
6. Mechanism of action of erdosteine
Erdosteine is a derivative of mercapto-amino acid, exists in the form of thiolactone, this is a prodrug that, after entering the body, will be converted into an active form and give mucolytic effects. Erdosteine has the effect of stabilizing mucus secretion, thinning sputum, making it easier for patients to spit out sputum (thanks to the free thiol groups in the Erdosteine metabolite, which will cleave disulfide bridges of bronchial mucoproteins). Erdosteine is an active ingredient with bronchoprotective effects, protecting the enzyme α1-antitrypsin by increasing the amount of IgA antibodies in the blood, increasing the ability to fight bacteria. In addition, this free thiol group of Erdosteine is also capable of inactivating oxidants, especially the inactivation of free radicals.
The advantage of the drug Erdosteine 300mg compared to other drugs of the thiol group is that it is less irritating to the stomach because the thiol group (SH) in the erdosteine molecule has been blocked by other groups.
After entering the body Erdosteine is rapidly absorbed after oral administration, about 64.5% of the amount of Erdosteine will be bound to plasma proteins. Erdosteine is eliminated mainly in the urine as a sulfate conjugate. Food has little effect on the absorption, metabolism and excretion of erdosteine 300mg. Accumulation of erdosteine and its metabolites with repeated dosing has not been adequately demonstrated.
Store erdosteine 300mg at room temperature, away from moisture, protect from light and do not store erdosteine 300mg in the bathroom or in the freezer compartment. Carefully read the instructions for storing erdosteine 300mg on the packaging or ask your pharmacist to keep erdosteine 300mg out of the reach of children and pets. Before using erdosteine need to carefully weigh the risks and benefits, consult your doctor for detailed information before using erdosteine 300mg.
Erdosteine 300mg medicine is used for symptomatic treatment of acute cough in chronic bronchitis. To ensure the effectiveness of treatment, patients need to take medicine according to prescription or consult a doctor or pharmacist.
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