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Levosulpiride drug is used to treat symptoms of indigestion in the gastrointestinal tract, schizophrenia... The following article will provide you with some information on usage, dosage, possible side effects. may occur during drug use.
1. What disease does levosulpiride treat?
Levosulpiride drug is usually indicated to treat the following cases:
Treatment of acute and chronic schizophrenia: this is the main indication of Levosulpiride. The drug is also used in patients with depression , anxiety disorders , psychosis . Treatment of symptoms of indigestion of the gastrointestinal tract such as belching, heartburn, nausea, vomiting, discomfort in the epigastrium, abdominal distention. In addition, the drug is also used to treat irritable bowel syndrome. Burning mouth syndrome (BMS) is a condition in which a patient experiences a burning sensation in the mouth without any identifiable cause. The pain is mainly localized to the tongue or lips. Levosulpiride at a dose of 100 mg/day has been shown to reduce burning or stinging sensations in the mouth. Acute Vestibular Disorders: Levosulpiride has been shown to improve symptoms in unilateral vestibular disorders. Use the drug at a dose of 25mg x 3 times / day for 10 days. Premature Ejaculation: Premature ejaculation can be treated with the use of antidepressants and other adjuvant medications. According to one study, taking levosulpiride 25 mg once daily for 60 days significantly improved ejaculation control.
2. What are the contraindications of Levosulpiride?
Contraindicated to use Levosulpiride or caution when using Levosulpiride in the following cases:
Hypersensitivity or allergy to any ingredient of Levosulpiride drug. Seizures or mania in schizophrenia. Breast cancer. Adrenal myeloma. Children under 14 years of age with Parkinson's disease Severe kidney or liver failure Asthma, cardiovascular disease Serious gastrointestinal disease, such as gastrointestinal bleeding, intestinal perforation, intestinal obstruction. Alcoholism Hypokalemia Pregnant and lactating women. The drug can pass into breast milk, so its use should be limited in lactating women.
Thuốc levosulpirid cần thận trọng với những đối tượng chống chỉ định
3. Levosulpiride dosage
The dose of Levosulpiride used by each patient will be adjusted, depending on age, physical condition and accompanying medical history. Specifically as follows:
For adults: Reduce symptoms of functional dyspepsia of the gastrointestinal tract: Take 75mg per day, divided into 3 times. Treatment of acute and chronic schizophrenia: 200-300mg per day, divided into 3 times.
Patients over 14 years old need to reduce the dose of the drug.
Children under 14 years old: Do not use the drug.
Patients with renal failure: reduce the dose or increase the interval between drug use. Depending on the creatinine clearance of the individual patient.
Creatinine clearance is 30-60ml/min: use 2/3 of the usual dose. Creatinine clearance is 10-30ml/min: about 1⁄2 of the usual dose. Creatinine clearance less than 10ml/min: use 1/3 of the usual dose. In addition to dose adjustments, patients can increase the interval between doses. However, in patients with severe renal impairment, Levosulpiride should not be used to avoid more serious side effects.
4. Some notes when using Levosulpiride drug
Take the medicine under the guidance of the doctor about the dosage as well as the duration of treatment.
Usually, Levosulpiride will start to work after about 1-2 hours of taking. The effect of the drug usually lasts from about 5-8 hours after taking the drug. For the drug to be effective, it is best to take it at least 30 minutes before eating.
Take Levosulpiride with plenty of water. Do not take with alcohol or other stimulants. During the time of taking the drug, if you experience allergic symptoms such as rash, itching, etc., you should quickly contact your doctor for instructions on handling.
Before using Levosulpiride, patients need to inform their doctor about their medical history and current condition. Use caution when using the drug in the following cases:
Renal failure, dose reduction and close monitoring during drug use is required. If renal impairment is severe, Levosulpiride should not be used or used intermittently. Epilepsy patients. Addiction to alcohol or stimulant drinks. Elderly. Because the drug can cause drowsiness, orthostatic hypotension. Patients with hypomania may make symptoms worse. Unexplained high fever. Patients with high fever should discontinue the drug to rule out neuroleptic malignant syndrome.
Người bệnh sử dụng thuốc levosulpirid không nên uống rượu
5. Unexpected side effects when using Levosulpiride
Below are some of the side effects that may occur while using Levosulpiride.
Common side effects (ADR > 1/100)
Endocrine: increased blood prolactin levels, increased lactation, increased breast size, menstrual disorders or amenorrhea. Treatment is by reducing the dose of Levosulpiride. Nervous: sedation, drowsiness or insomnia. Rare side effects when using Levosulpiride (1/1000 < ADR < 1/1000)
Cardiovascular: arrhythmia, torsades de pointes. Nervous system: extrapyramidal syndrome. Parkinson's syndrome or overstimulation. Rare side effects when using Levosulpiride (ADR < 1/1000)
Nervous system: Causes neuroleptic malignant febrile syndrome, tardive dyskinesia. Endocrine: large breasts in men. Blood pressure: Slowing or arrhythmia, orthostatic hypotension. Other side effects: Sensitivity to light, hypothermia, cholestatic jaundice, increased liver enzymes, weight gain.
6. Levosulpiride drug interactions
Because taking more than one drug at the same time can reduce the therapeutic effect or change the mechanism of action of the drug, increasing the risk of side effects. Therefore, patients need to pay attention and tell their doctors all the medicines they are taking, including vitamins and herbs. Some drugs may interact with Levosulpiride:
Sucralfate, aluminum-magnesium hydroxide antacids: Levosulpiride should be taken at least 2 hours after the above drugs to avoid reducing the absorption of Levosulpiride. Lithium: increases the risk of extrapyramidal disorders. Alcohol: Avoid taking the drug with alcohol and other alcoholic beverages because it can increase the sedative effect, causing drowsiness. Levodopa: Do not take Levosulpiride concomitantly with Levodopa. Because Levodopa can compete with Levosulpiride to reduce the effect of the drug. Medications to treat high blood pressure: Levosulpiride may increase the ability of this medicine to lower blood pressure. In addition, the patient may experience postural hypotension. Other CNS depressants: Levosulpiride may increase CNS depression and cause serious consequences. Especially in people who need to stay awake or operate machinery. Therefore, special care must be taken when combining these drugs.
Thuốc levosulpirid có thể tương tác với một số loại thuốc huyêt áp
7. How to handle an overdose of Levosulpiride
Levosulpiride overdose symptoms are common when patients take a dose of 1 - 16g. However, there have been no reports of death in patients when taking Levosulpiride at a dose of 16g. Symptoms of overdose vary depending on how much or how little the dose is taken. Specifically as follows:
Overdose of the drug 1 - 3g: gloomy state of consciousness, restlessness, rare extrapyramidal symptoms. Over 3-7g: agitation, confusion and higher risk of extrapyramidal syndrome. Overdose > 7g: In addition to the above symptoms, the patient may have hypotension, coma. Usually symptoms go away after a few hours. However, if a coma occurs when using the drug in high doses, it can last up to 4 days. The above is important information about Levosulpiride, you should refer to it carefully to achieve high efficiency.
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