This is an automatically translated article.
Staclazide 60 MR with the main active ingredient is Gliclazide for the treatment of non-insulin dependent diabetes mellitus type 2. So how does Staclazide affect the effectiveness of the treatment? We invite you to read the following article
1. What is Staclazide 60 MR?
Staclazide 60 MR drug with the main ingredient Gliclazide 60 mg is usually indicated for the treatment of non-insulin dependent diabetes mellitus in which diet alone does not control blood glucose.
Currently, Staclazide 60 MR is made in the form of extended-release tablets, oval, white, smooth on both sides. Box of 3 blisters x 10 tablets.
2. Pharmacodynamics of Staclazide 60 Mr
Pharmacology Gliclazide is an oral sulfonylurea type 2 antidiabetic drug. The main effect of Gliclazide is to stimulate the beta cells located in the pancreas to release insulin, so the drug only works when the patient's pancreas is still working (still able to produce insulin). When using Gliclazide, patients need to combine with diet, daily exercise.
Pharmacokinetics Gliclazide is readily absorbed from the gastrointestinal tract. The maximum plasma concentration of the drug is reached about 2 - 4 hours after oral administration. Normally, food does not change the rate and extent of absorption.
The drug is able to bind to plasma proteins (85 - 95%). The duration of action lasts 12 hours or more.
Gliclazide is extensively metabolised in the liver to inactive products. Unmodified drugs and metabolites are mainly excreted in the urine (60 - 70%); About 10-20% is excreted in the feces as metabolites.
The half-life of Gliclazide is about 10 -12 hours.
3. Notes when using Staclazide 60Mr
Normally, Staclazide 60 Mr is taken orally, a single dose at breakfast, swallowed whole.
The starting dose is 30 mg per day (1 Staclazide 30MR tablet). If blood glucose control is achieved, it can be considered as a maintenance dose. If blood glucose control is not achieved, the dose can be gradually increased to 60 mg (2 tablets), 90 mg (3 tablets), 120 mg (4 tablets)/day in increments, spaced at least 1 month apart. except for patients whose blood glucose did not respond to a decrease after 2 weeks of treatment. In this case, the dose can be increased immediately after the 2nd week of treatment.
The maximum dose is 120 mg (2 tablets) per day.
Gliclazide can be combined with metformin, α-glucosidase inhibitors (eg acarbose) or with insulin. When combined with insulin, medical supervision is required.
For the elderly, especially note and use under the guidance of the doctor. In patients with mild to moderate renal impairment, dose as recommended with careful monitoring. These data have been confirmed in clinical trials.
For children, safety and effectiveness have not been established. In general, to get the right dose, you need to consult your doctor or medical professional.
If you forget a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Note that double the prescribed dose should not be taken.
Before using the drug you need to carefully read the instructions for use and consult the treating doctor.
Staclazide 60 MR is contraindicated in the following cases:
Patients who are sensitive to Gliclazide or any of its ingredients; Type 1 diabetes; Diabetes has entered the pre-coma or coma stage, diabetic ketoacidosis; Severe infection or trauma, major surgery; Severe liver and kidney failure; Are being treated with Miconazole; Women are breastfeeding.
4. Staclazide 60 MR . side effects
When using Staclazide 60 MR, you may experience unwanted effects such as:
Causes hypoglycemia; Central Nervous System: Headache; Gastrointestinal: Gastrointestinal disturbances, nausea; Skin: Rash. Some rarer reactions such as blood disorders: Thrombocytopenia and white blood cells, agranulocytosis, anemia; skin and mucous membrane reactions; lethargy, sweating, pale skin. When experiencing side effects of the drug, it is necessary to stop using it and notify the doctor or go to the nearest medical facility for timely treatment.
In summary, Staclazide 60 MR is effective in the treatment of non-insulin dependent type 2 diabetes. Patients need to take the drug exactly as prescribed by the doctor to increase the effectiveness of treatment and ensure safety for health.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
