This is an automatically translated article.
Staclazide is a product of STELLAPHARM Joint Venture Co., Ltd. Gliclazide is used to treat non-insulin dependent diabetes mellitus (type 2) where diet alone does not control blood glucose.
1. What is Staclazide? Ingredients of Staclazide 30 mr
Staclazide is available as a white, oval, biconvex, extended-release tablet. In each tablet contains ingredients, including:
Active ingredients: In one tablet contains Gliclazide 30 mg Excipients: Calcium hydrophosphate dihydrate, anhydrous colloidal silica, magnesium stearate, hypromellose 100 cps, maltodextrin.
2. Uses of Staclazide 30 mr
2.1 Indications of Staclazide 30 mr Staclazide 30 mr is indicated for use in the following cases: The patient is being treated for non-insulin-dependent diabetes mellitus (type 2) but diet alone cannot control the amount of diabetes. blood glucose.
2.2 Pharmacodynamics Gliclazide is a type 2 (non-insulin-dependent) anti-diabetic active ingredient of the sulfonylurea group, administered orally. The main effect of gliclazide is to stimulate pancreatic beta cells to release insulin. Therefore, this drug only works when the patient's pancreas is still functioning (meaning it is still able to produce insulin). Doctors often prescribe Gliclazide in combination with diet and exercise. Gliclazide can be used alone or in combination with other hypoglycemic agents such as insulin, metformin.
2.3 Pharmacokinetics Absorption: In terms of absorption, Gliclazide is readily absorbed from the gastrointestinal tract. About 2 to 4 hours after the patient takes the drug, the drug will reach peak plasma concentrations. Food does not change the rate and extent of drug absorption. Distribution: Staclazide is strongly bound to plasma proteins (85-95%). Its effect lasts 12 hours or more. Metabolism: The metabolism of Gliclazide is extensive in the liver and into inactive products. Elimination: Unmodified drug and metabolites are eliminated mainly in the urine (60 - 70%); A few about 10 - 20% are excreted in the feces as metabolites. The half-life of gliclazide ranges from 10 to 12 hours.
3. Dosage of Staclazide 30 Mr
3.1 How to use According to the product's instructions for use, Staclazide 30 mr takes a single dose in the morning, the patient needs to swallow the tablet whole and do not share half.
3.2 Dosage The starting dose is 30 mg per day (equivalent to 1 tablet). If blood glucose control is achieved, this can be considered as a maintenance dose. If blood glucose control is not achieved, the dose can be gradually increased to 60 mg (2 tablets respectively), 90 mg (3 tablets respectively), 120 mg (4 tablets respectively)/day in increments.
Doses are spaced at least every 1 month, except in patients whose blood glucose has not responded to a decrease after 2 weeks of drug therapy. In this case, the dose can be increased immediately after the second week of treatment. The maximum dose of Staclazide 30 mr is 120 mg (4 tablets) per day. Gliclazide can be used in combination with metformin and α-glucosidase inhibitors (eg acarbose) or in combination with insulin. When using combination therapy with insulin, it is necessary to have a doctor's supervision and prescription.
3.3 Special populations Patients with renal impairment
For patients with mild to moderate renal impairment use the dose as recommended for patients with normal renal function with special careful monitoring. These data have been demonstrated in clinical trials.
Patients at risk of hypoglycemia
People who stop long-term treatment or take high doses of corticosteroids. People with severe vascular disease (severe coronary artery disease, disseminated vascular disease, severe carotid insufficiency). People with malnutrition or malabsorption. People with severe or poorly compensated endocrine disorders (adrenocortical insufficiency, hypopituitarism, hypothyroidism). A minimum starting dose of 30 mg/day is recommended. Children
There are no data on the safety and efficacy of Staclazide 30 MR in children and adolescents. Therefore, this subject also needs special attention when using the drug.
Note: The above dosage is for reference only. The specific dose depends on the condition and the progression of the disease in each person. To get the right dose, you need to consult your doctor or medical professional before using the drug.
4. What to do if Staclazide 30 MR overdose?
When using the drug overdose can cause hypoglycemia.
In mild cases, treat hypoglycemia by giving the patient immediately glucose or sugar 20-30g mixed in a glass of water and monitoring blood glucose. Give the patient a drink every 15 minutes until blood glucose returns to normal. Carbohydrate supplementation, dose adjustment, and dietary modification are required in cases of moderate hypoglycaemia, without loss of consciousness or neurological signs. For severe hypoglycaemic reactions with coma, convulsions or neurological disturbances, medical assistance should be sought. If hypoglycaemia with coma is diagnosed or suspected, 50 mL of a high-concentration glucose solution (20 to 30%) should be given rapidly intravenously. After that, a more dilute (10%) glucose solution should be continued infusion at a rate that can maintain a blood glucose level of about 1 g/l.
5. What to do if you miss a dose of Staclazide 30 MR?
If you forget a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Never take a double dose that has been prescribed.
6. Staclazide 30 MR . side effects
When using Staclazide 30 MR, you may experience some undesirable effects (ADRs) as follows:
Common effects ADR > 1/100
Metabolism: Hypoglycaemia. Skin: Rash, redness of the skin. Central nervous system: Headache. Gastrointestinal: Gastrointestinal disturbances, nausea and vomiting. Uncommon effects, 1/1000 < ADR < 1/100
Blood: Thrombocytopenia, leukopenia, anemia, agranulocytosis. Skin: Redness of the skin, mucous membranes. Rare effects (10,000 < ADR < 1/1000)
Cardiovascular: Increased heart rate. Skin: Green, pale. Central Nervous System: Appears in a state of lethargy, sweating. Digestion: Vomiting, hunger pangs. Instructions on how to handle ADR: When experiencing one of the side effects of the drug, the first thing you need to do is stop using it. After that, notify the doctor or go to the nearest medical facility for timely treatment.
7. Note when taking Staclazide 30 mr
Before using Staclazide 30mr, you need to carefully read the instructions for use and note some of the information below:
Staclazide 30 MR is contraindicated in the following cases:
Patients who are sensitive to gliclazide or any ingredient in the drug. Patients with type 1 diabetes. Diabetes has entered a pre-coma or coma. Diabetic ketoacidosis. Patients with severe infection or major trauma or major surgery. Patients with severe liver and kidney failure. The patient is being treated with miconazole. Women are breastfeeding.
8. Drug interactions
Increased blood glucose lowering effect: Alcohol ACE inhibitors, allopurinol, analgesics (especially azapropazone, phenylbutazone and salicylates), fluoroquinolones, heparin, MAOIs, ranitidine, sulfinpyrazone, sulfonamides (including co- trimoxazol), nitrogen-containing antifungals (fluconazole, ketoconazole and miconazole), chloramphenicol, cimetidine, clarithromycin, clotibrate and related compounds, coumarin anticoagulants, tetracyclines and tricyclic antidepressants.
Beta blockers may reduce the effectiveness of sulfonylureas. It is caused by a decrease in the release of insulin from the pancreas. This drug is a beta-receptor blocker and may also inhibit the normal physiological hypoglycaemic response. Simultaneously mask the typical warning sympathetic signs.
Terbutalin (intravenous route), ritodrin, salbutamol: Hyperglycemia by beta stimulants. You should increase blood glucose monitoring, or if necessary, switch to insulin.
Staclazide has the main ingredient Gliclazide, used to treat non-insulin dependent diabetes mellitus (type 2) while diet alone does not control blood glucose. To ensure the effectiveness of treatment and avoid side effects, patients need to take medicine according to prescription or consult a doctor, professional pharmacist.
Follow Vinmec International General Hospital website to get more health, nutrition and beauty information to protect the health of yourself and your loved ones in your family.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
