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Transmetil is used to treat symptoms of cholestasis in cirrhosis, pre-cirrhosis, especially in pregnant women, and depressive symptoms. The drug is prepared in the form of enteric coated tablets, box of 1 blister x 10 tablets. Understanding the effects as well as following the correct indications and doses of Transmetil will help patients use the drug effectively and safely.
1. What is Transmetil?
The ingredient in each Transmetil tablet is Ademetionine 500 mg.
Ademetionine is a form of the amino acid methionine or S-adenosylmethionine, which is an intermediate metabolite of methionine. This active ingredient is involved in the methylation process that helps in cell growth and repair, maintaining the phospholipid layer in the cell membrane. Ademetionine, found in the brain and liver, helps keep neurotransmitters or certain other hormones active and helps regulate mood.
Normally, Ademetionine is fully synthesized by the body to ensure good health. However, a deficiency of methionine, folate or vitamin B12 common in cases of cholestatic cirrhosis can lead to a decrease in Ademetionine levels. Ademetionine deficiency needs to be supplemented in the form of a drug because this active ingredient does not exist in food. S-adenosylmethionine not only has an important role in the immune system, but it also helps maintain cell membranes and helps produce brain chemicals like serotonin, dopamine or melatonin.
2. Indications of the drug Transmetil
Transmetil is indicated in the treatment of:
Cholestasis in cirrhosis or pre-cirrhosis. Pregnant women with intrahepatic cholestasis. Treatment of depressive symptoms. Transmetil should not be used in the following cases:
Patients with a history of hypersensitivity to any ingredient in Transmetil. Children, unless absolutely necessary.
3. Dosage and how to use Transmetil
3.1. How to use Transmetil is taken orally. Patients take Transmetil tablets whole with half a glass of water, do not break, crush or chew as this will reduce the absorption of the drug. Transmetil should not be taken with food. In human users, it is recommended to start with intramuscular or intravenous injection before maintenance orally or can start with oral immediately.
3.2. Dosage Treatment of cholestasis in cirrhosis or pre-cirrhosis:
Initiation: 5-12 mg/kg/day intramuscularly or intravenously for the first 2 weeks. Maintenance: 10-25 mg/kg/day orally. Treatment of depressive symptoms:
Initiation: 400 mg intramuscularly or intravenously during the first 15-20 days of treatment. Maintenance: 800-1200 mg/day. Children: The safety and effectiveness of Transmetil have not been established in this population.
Elderly: should start with the lowest possible dose in the allowable range.
4. Side effects of the drug Transmetil
Patients may experience some side effects when treated with Transmetil 500mg such as:
Common: gastrointestinal disturbances such as nausea, abdominal pain, diarrhea. Other side effects: skin and subcutaneous tissue disorders, neurological disorders, asthenia, injection site reactions, musculoskeletal and connective tissue disorders: arthralgia, muscle spasticity or peripheral edema. Patients experiencing any symptoms that are suspected to be side effects caused by taking Transmetil should inform their treating physician for advice on safe and timely handling.
5. Interactions of the drug Transmetil
Transmetil can interact if used concurrently with drugs and substances such as:
Selective serotonin reuptake inhibitors Tricyclic antidepressants Over-the-counter medicines that contain the ingredient Tryptophan. Medicines of herbal origin Patients should inform their doctor about any drugs or functional foods that they are using for advice and consideration before starting treatment with Transmetil to avoid encountering problems. interactions that affect drug efficacy.
6. Notes when using the drug Transmetil
Patients with pre-cirrhosis and cirrhosis need to control ammonia levels during treatment Ademetionine should not be used in patients with bipolar disorder because of the potential for transition from depression to hypomania or mania. mania Use caution when using Transmetil in the elderly, kidney failure Serotonin syndrome may occur in some patients receiving Ademetionine and Clomipramine Short-term treatment of depression 3-6 weeks has been demonstrated. , however, long-term efficacy has not been studied. Patients with depression need psychological support during treatment with Transmetil Do not operate machinery, drive or do activities that require concentration while using Transmetil until it is certain that there is no effect. drugs interfere with these activities. Pregnant women: Pregnant women in the last 3 months can use Transmetil in high concentrations. However, during the first trimester of pregnancy, the benefits and risks should be weighed before deciding to treat with Transmetil. Lactation: The ability to excrete Transmetil into breast milk has not been studied, so caution should be exercised when using this drug for this population. Absolutely do not use if Transmetil tablets are watery, change color, taste or have expired. Above is all information about Transmetil, patients need to carefully read the instructions on the package, consult a doctor, strictly follow the indications and dosage to use the drug effectively.
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