Silymarin 70mg contains the main ingredient, Silybum marianum extract, along with other inactive ingredients. The medication helps protect and restore liver function, and supports the treatment of chronic hepatitis, cirrhosis, and liver damage caused by toxins.
1. The Pharmacological Effects of Silymarin
Silymarin, a bioactive compound extracted from the milk thistle plant (Silybum marianum), is widely recognized for its hepatoprotective properties. This compound has been traditionally used for its diverse therapeutic benefits, such as reducing fever, controlling bleeding, and treating dysentery. Its fruit has also demonstrated effects in regulating blood pressure, alleviating asthma and cough, and mitigating liver pain.
In modern medicine, Silymarin is primarily utilized for its ability to safeguard the liver from damage caused by toxins, inflammatory agents, and harmful substances such as chemicals, alcohol, and certain medications. Its hepatoprotective and regenerative functions operate through well-established mechanisms:
- Silymarin neutralizes reactive oxygen species and free radicals that can cause oxidative stress and cellular damage in the liver.
- Enhances the structural integrity of hepatocyte membranes, reducing the influx of toxins into liver cells.
- Promotes the repair and regeneration of damaged liver cells while fostering the proliferation of new hepatocytes.
- Silymarin inhibits the activation of hepatic stellate cells, thereby reducing collagen deposition and preventing the progression to liver fibrosis or cirrhosis.
Silymarin not only protects liver cells but also optimizes the liver's functional architecture, enhancing its capacity for detoxification and metabolic processing. Clinical studies have demonstrated its efficacy in managing conditions such as hepatic dysfunction, degenerative liver diseases, and elevated liver enzymes.
Furthermore, regular administration of Silymarin (e.g., at a dose of 70 mg) has been shown to improve liver enzyme profiles and support the recovery of hepatic function. Emerging evidence also suggests potential anti-cancer properties, making Silymarin a valuable adjunct in liver health management.
2. Adverse Effects of Silymarin 70mg
Silymarin 70mg is rarely associated with side effects. However, some people may experience the following issues:
- Digestive problems: nausea, vomiting, loss of appetite, indigestion, bloating, abdominal discomfort, stomach pain, diarrhea.
- Headaches, dizziness, fatigue.
- Allergic skin reactions: red rashes, itching.
If you experience any of these side effects, inform your doctor so they can provide appropriate treatment or adjustments.
3. Indications for Using Silymarin 70mg
- Helps treat liver diseases such as acute or chronic hepatitis, cirrhosis, and fatty liver.
- Protects liver cells and helps restore liver function in cases of liver toxicity caused by factors like excessive alcohol use, metabolic disorders (such as fat accumulation in the liver), food or chemical poisoning, liver-damaging drugs, mushroom toxins, or carbon tetrachloride.
- Supports the treatment of liver dysfunction, with symptoms such as fatigue, poor appetite, indigestion, skin rashes, and itching.
4. Contraindications for Silymarin 70mg
Silymarin 70mg should not be used in individuals who:
- Are allergic to silymarin or any of the ingredients in the medication.
- Have severe bile duct issues or advanced liver failure.
- Are children under 12 years old.
- Have diabetes.
Silymarin 70mg is also not recommended for pregnant or breastfeeding women, or individuals under 18, as there is insufficient data on the safety of the drug for these groups.
5. How to Use and Dosage of Silymarin 70mg
5.1 How to Take Silymarin 70mg:
- Take the medication with a sufficient amount of water (about one glass), either before or during meals, unless your doctor gives different instructions.
- If side effects last a long time, inform your doctor.
- Follow your doctor's instructions carefully: do not take more or less than the prescribed dose, and do not stop taking the medication without your doctor’s approval.
5.2 Usual dosage for adults:
- Liver protection: The typical dose is 70-140mg per dose, 2-3 times a day for 6-8 weeks. After this, a maintenance dose of 280mg per day may be suggested or as prescribed by your doctor.
For chronic liver disease, treatment may last from at least 2 months to several years. In cases of chronic hepatitis, cirrhosis, or liver fibrosis, lifelong treatment may be needed. Your doctor will adjust the dosage according to your condition. - Mushroom poisoning: 33mg/kg/day. Elderly people and those with kidney problems do not need a dose adjustment. However, older people with kidney issues should be monitored, and the dose may need to be reduced if necessary.
5.3 If you take too much:
Silymarin 70mg is not harmful even in high doses. However, taking too much may cause mild laxative effects and increase side effects.
Treatment: No special treatment is usually required. Most symptoms will disappear within 24 to 48 hours after stopping the medication. If needed, your doctor may give treatment for symptoms and provide supportive care.
5.4 If you miss a dose:
If you forget to take a dose, take it as soon as you remember. However, if the next dose is almost due, skip the missed dose and take your next dose as planned. Do not take two doses at once.
6. Drug interactions with Silymarin 70mg
Silymarin 70mg may affect how other medications work or increase the risk of side effects. It should not be taken with levodopa or metronidazole. It may also interact with medications for mental health conditions, stroke, or anesthesia.
To avoid possible drug interactions, make a list of all medications you are taking (prescription, over-the-counter, herbal, or dietary supplements) and show it to your doctor. Never adjust your doses or stop taking medications without your doctor's advice.
7. Important notes when using Silymarin 70mg
Pregnant or breastfeeding women should consult their doctor before using this medication. Silymarin may lower blood sugar, so people with diabetes or low blood sugar should monitor their levels.
If you experience any of the following, stop using the medication and inform your doctor or pharmacist:
- Stomach pain or diarrhea
- Signs of an allergic reaction to Silymarin 70mg
When using Silymarin 70mg:
- Do not exceed the prescribed dose.
- If you notice jaundice, inform your doctor.
- If your symptoms do not improve after using the medication for a long time or after one month of treatment, contact your doctor or pharmacist.
8. How to store Silymarin 70mg
To store Silymarin 70mg properly, follow these guidelines:
- Keep the medication out of reach of children.
- Store it in its original packaging and keep it away from direct sunlight.
- Keep the medication at room temperature, below 30°C.
- Do not use the medication after the expiration date printed on the packaging.
- Always read the instructions on the packaging before using the medication.
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