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Supirocin medicine has the active ingredient Mupirocin, an antibiotic used to treat skin infections and prevent infections at the site of catheter removal or after skin surgery. The mechanism of action of mupirocin is to bind specifically to the bacterial enzyme isoleucyl transfer-RNA synthetase, thereby stopping protein synthesis and inhibiting RNA synthesis.1. Uses of Supirocin
Supirocin has the active ingredient Mupirocin, an antibiotic used for the local treatment of skin infections and for the prevention of infections at the site of catheter removal or after skin surgery. Mupirocin is an antibiotic produced by Pseudomonas fluorescens and is structurally different from other antibiotics. Mupirocin's mechanism of action is to bind specifically and reversibly to the bacterial enzyme isoleucyl transfer-RNA synthetase, thereby stopping protein synthesis and inhibiting RNA synthesis. Thanks to this mechanism of action, the rate of occurrence of mupirocin-resistant staphylococci in in vitro studies is low, and cross-resistance with other topical antibiotics has not occurred.Topical mupirocin has a very low bioavailability (approximately 0.24%). The permeability of Mupirocin is increased when the wound is covered with a bandage or when the drug is applied to the damaged skin. Mupirocin is slowly metabolized in the skin to monic acid, an inactive metabolite. Only a very small amount of mupirocin is absorbed, metabolised and eliminated mainly by the kidneys. Supirocin medicine can be indicated in the following cases:
Used topically to treat primary and secondary skin infections caused by susceptible bacteria such as impetigo, burns, infected wounds. secondary, cellulitis, chronic leg ulcers,... Prophylaxis of infection at the catheter removal site and prevention of infection after skin surgery.
2. Usage of Supirocin 5g
Supirocin 5g is an ointment for topical application. The specific dosage is as follows:Adults
The recommended dose is to apply a thin layer of Supirocin ointment 5g to the affected areas of the skin 2-3 times daily for 5 to 10 days for infected patients. primary and secondary skin bacteria. The patient may cover the application area with gauze if necessary. Note that Supirocin is only used to treat wounds with a length of less than or equal to 10cm or an area of less than or equal to 100cm2. If the patient does not see any effect after 3-5 days of treatment, they should stop using it and go to the doctor again. Patients with more severe infections may need longer. Especially if there are signs of systemic infection, the patient needs to take antibiotics by injection or oral for systemic effect.
Children
Available data show that Mupirocin ointment is safe and effective when applied topically to children 2 months to 16 years of age. The safety and effectiveness of Mupirocin ointment for children under 2 months of age have not been established, so it should not be used in this population. In the case of impetigo, a small amount of Mupirocin can be applied to the affected area 3 times daily. If there is no improvement after 3-5 days of treatment, stop the drug and go back to the doctor. The way to apply the medicine to children is similar to that of adults, but it is best to take only a moderate amount, with less medicine and a longer interval between applications than adults.
3. What to do in case of an overdose of Supirocin?
Current data indicate that either an intravenous infusion of 252 mg of mupirocin or a single oral dose of 500 mg of mupirocin is well tolerated in healthy adult volunteers. There are not many data on the use of Mupirocin ointment. There are no reports of an overdose of Mupirocin ointment. Because mupirocin is very poorly absorbed through the skin, overdose is very rare.4. What are the side effects of Supirocin?
Common, ADR >1/100Patients may experience burning, itching, pain or prickling sensation at the site of application
Uncommon, rare, ADR < 1/100:
Local : Rash, dry skin, swelling, sensitive skin, contact dermatitis, increased exudation. Body as a whole: Vomiting, nausea Instructions for handling ADR
When experiencing side effects of Supirocin, patients need to stop using the drug and notify the doctor or go to the nearest medical facility for treatment.
5. Notes when using Supirocin
Supirocin is contraindicated in patients with known or suspected hypersensitivity to Mupirocin or any of the excipients. Supirocin ointment contains polyethylene glycol and should not be used on broken skin or mucous membranes, open wounds and burns because polyethylene glycol can be absorbed and then excreted by the kidneys. Supirocin should not be used in cases where large amounts of polyethylene glycol can be absorbed, especially in patients with moderate or severe renal impairment. Do not use topically, orally or intravaginally. Note that this is a drug for external use, so avoid applying large amounts of medicine and over a large area. Patients should be cautious when using it for conditions that increase drug absorption such as large amounts of drug, prolonged application, application to damaged skin and occlusive dressing. Prolonged use of the drug can lead to the development of resistant microorganisms. Ability to drive and use machines: The drug has no known adverse effects on the ability to drive or use machines. Pregnancy: Animal studies are not always predictive of human response. Therefore, the drug should only be used by pregnant women in cases where it is absolutely necessary. Lactation: It is not known whether Supirocin ointment is excreted in human milk. Mupirocin should be used with caution in nursing women. Drug Interactions: Interactions resulting from the concomitant use of Mupirocin ointment and other systemic or topical agents have not been extensively studied. However, because mupirocin is very poorly absorbed through the skin, drug interactions with systemic agents are unlikely. In summary, Supirocin is an ointment for the treatment or prevention of skin infections caused by susceptible bacteria. As with other antibiotics, overuse can increase antibiotic resistance. Therefore, patients should not self-medicate, but should consult a medical professional before using.Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
