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Pandatox contains the active ingredient Cefpodoxime proxetil 200mg, which is prepared in the form of long film-coated tablets. The drug is used to treat people with respiratory tract infections, urinary tract infections, gonorrhea. Learn more about the uses and notes when using Pandatox through the article below.1. Uses of the drug Pandatox
1.1. Pandatox is indicated for the treatment of infections caused by susceptible bacteria:
People with respiratory infections such as acute otitis media, sinusitis, tonsillitis, pharyngitis, bronchitis. Community-acquired acute pneumonia caused by strains of Streptococcus pneumoniae or Haemophilus influenzae or beta-lactamase. Uncomplicated acute gonococcal infection in the endocervix, anorectal of women. Uncomplicated mild to moderate urinary tract infections caused by susceptible organisms such as Proteus mirabilis or Staphylococcus saprophyticus. Mild to moderate skin and skin tissue infections caused by Staphylococcus aureus, susceptible strains of Streptococcus pyogenes 1.2. Pharmacodynamic properties Cefpodoxime is a 3rd generation cephalosporin antibiotic with a broad spectrum of antibacterial activity, used orally. The drug is not altered by beta lactamases and is active against both Gram-negative and Gram-positive bacteria. Cefpodoxime-sensitive Gram-negative and Gram-positive bacteria include: Streptococcus and non-beta lactamase-producing, Staphylococcus aureus,... Mechanism of action: Acylation of membrane-bound transpeptidase enzymes to prevent cross-linking peptidoglycan chains of the bacterial cell wall, helping cefpodoxime to synthesize the bacterial cell wall. 1.3. Pharmacokinetic properties Cefpodoxime proxetil is rapidly absorbed and hydrolysed to Cefpodoxime after oral administration. Cefpodoxime proxetil is absorbed from the gastrointestinal tract and metabolised by nonspecific esterases to the active metabolite cefpodoxime in the intestinal wall. Food increases the absorption of the drug. The bioavailability of Cefpodoxime is approximately 50% and is increased when administered with food. In healthy adults with normal renal function, after oral administration of 1 dose of Cefpodoxime, peak plasma concentrations are reached 2-3 hours after oral administration. Cefpodoxime is about 40% bound to plasma proteins. The drug is excreted unchanged by the kidneys; approximately 33% of the dose is excreted in the urine within 12 hours in adults with normal renal function. The drug does not occur biotransformation in the kidneys and liver.
2. Dosage and how to use Pandatox
Users can refer to the dosage of Pandatox as follows:
Adults and children over 12 years old:
For patients with respiratory infections, pharyngitis, tonsillitis: Take 1⁄2 tablets equivalent to with 100mg every 12 hours, for 5-10 days. Patients with acute community-acquired pneumonia or acute exacerbation of chronic bronchitis: Take 1 tablet, equivalent to 200mg every 12 hours, for 14 days. Uncomplicated gonococcal infection: A single dose of 1 tablet is equivalent to 200mg. Skin and skin tissue infections: 2 tablets equivalent to 400mg every 12 hours, for 7-14 days. Uncomplicated urinary tract infections: 1⁄2 tablets equivalent to 100mg every 12 hours, for 7 days. Patients with renal impairment (creatinine clearance less than 30ml/min) and not on hemodialysis: Take the usual dose and take it only once a day. For patients with renal failure undergoing hemodialysis, the usual dose is 3 times a week. Patients with cirrhosis : No dosage adjustment is required. Children under 12 years old:
Dosage depends on the weight of the child, should use other dosage forms for children such as powdered medicine, syrup for appropriate use and division of doses. The above recommended therapeutic dose for Pandatox is for reference only. Therefore, patients need to use the drug as prescribed by the treating doctor to ensure safety and achieve the best effect.
2.2. Overdose and management Some symptoms when using Pandatox 200 overdose include: Nausea, vomiting, dizziness, epigastric pain, diarrhea. In the event of a severe toxic reaction due to an overdose, cefpodoxime can be eliminated from the body by hemodialysis or peritoneal dialysis, especially in patients with impaired renal function.
3. Pandatox side effects
Some common side effects of the drug such as:
Nausea, vomiting, abdominal pain, diarrhea. Itching, hives, rash. Uncommon symptoms:
Allergic reactions, fever, joint pain. Erythema multiforme, dermatitis, transient cholestatic jaundice. Liver enzyme disorders. Rare symptoms:
Increased activity, dizziness, trouble sleeping, confusion. Increase muscle tone. Eosinophilia increased. Reversible interstitial nephritis or blood disorders. When abnormal symptoms or undesirable effects appear, it is necessary to immediately stop using the drug, consult a doctor to diagnose the condition and take timely measures.
4. Pandatox drug interactions
Some Pandatox drug interactions are as follows:
Concomitant use of Probenecid with Cefpodoxime increases the drug concentration in the blood plasma. Concomitant administration of antacids or H2 inhibitors with cefpodoxime reduces plasma concentrations by approximately 30%. Positive direct Coomb test for Cephalosporins.
5. Some notes when using Pandatox 200
Use caution when using Pandatox 200 with people who are sensitive to penicillin, beta lactamases and any of its ingredients. People with a history of allergies, renal insufficiency should have a doctor's supervision when using the drug. For pregnant women: Although there have been no reports showing any teratogenic or toxic effects to the fetus, the drug should only be used when absolutely necessary. Lactation: Cefpodoxime is excreted in breast milk in low concentrations. However, it is necessary to avoid taking the drug while breastfeeding or stop breastfeeding while using the drug. Above is important information about Pandatox, patients should carefully read the instructions for use and use according to the dose prescribed by the doctor to achieve the best effect.
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