This is an automatically translated article.
Safrox is a 3rd generation Cephalosporin antibiotic, belonging to the group of antifungal, antiviral, anti-infective, and anti-parasitic drugs with a broad antibacterial spectrum. The drug has the main active ingredient is Cefpodoxime (in the form of Cefpodoxime proxetil) and the effect of this active ingredient is to inhibit the synthesis of the bacterial cell wall.1. Safrox brand-name drug
Safrox is a 3rd generation cephalosporin antibiotic, belonging to the group of antifungal, antiviral, anti-infective, anti-parasitic drugs with a broad antibacterial spectrum, with the main active ingredient being Cefpodoxime (in the form of Cefpodoxime proxetil). The drug is manufactured in the form of film-coated tablets with a strength of 100mg of Cefpodoxime each.2. What does Safrox do?
Safrox has a bactericidal effect by inhibiting bacterial cell wall synthesis. The drug is used to treat infections with bacteria sensitive to Safrox due to acylation of membrane-bound transpeptidase enzymes, thereby making the bacterial cell wall less stable and destroyed. Safrox is effective against both Gram-negative and Gram-positive bacteria.Safrox is indicated in the following cases:
Upper respiratory tract infections, including sinusitis, tonsillitis and pharyngitis; Acute otitis media ; Community-acquired acute pneumonia; Uncomplicated urinary tract infections; Uncomplicated acute gonococcal infection; Skin and soft tissue infections. Absolutely do not use Safrox drug in patients who are sensitive to any of the ingredients or antibiotics of the Cephalosporin and Penicillin groups.
3. Dosage and usage of Safrox
3.1. How to use Safrox The patient takes Safrox as prescribed by the doctor. Safrox is available as a film-coated tablet for oral administration. Before using, it is necessary to carefully read the instructions on how to use Safrox on the drug leaflet. Patients should take Safrox with food to increase the absorption of the drug from the gastrointestinal tract.
3.1. Dosage of Safrox The dose of Safrox drug varies based on the type of susceptible bacteria, the severity of the infection and the patient's condition, so patients should not arbitrarily increase or decrease the dose of the drug without the indication of the doctor. doctor.
Adults:
Acute exacerbation of chronic bronchitis or mild to moderate community-acquired pneumonia: The usual dose is 200 mg/time x 2 times/day, lasting for 10–14 days. Pharyngitis, tonsillitis caused by Streptococcus pyogenes infection: Dose 100mg/time x 2 times/day, lasting for 5-10 days. Uncomplicated mild to moderate skin and skin tissue infections: The usual dose is 400mg/time x 2 times/day, lasting for 7–14 days. Uncomplicated mild to moderate urinary tract infections: 100mg/time x 2 times/day, lasting for 7 days. Uncomplicated gonorrhea: Use a single dose of 200mg or 400mg, then continue treatment with oral antibiotic doxycycline to prevent Chlamydia infection. Children:
Children aged 2 months to 12 years:
Acute otitis media: Dose 5mg/kg/time (maximum 200mg) x 2 times/day, lasting for 5 days. Pharyngitis and tonsillitis caused by S. pyogenes group A: Dose 5mg/kg/time (maximum 100mg) x 2 times/day, lasting for 5-10 days. Mild to moderate acute sinusitis and purulent sinusitis: Dose of 5mg/kg/time (maximum 200mg) x 2 times/day, lasting for 10 days. Uncomplicated gonorrhea (8 years old, weight ≥ 45kg): A single dose of 400mg and combined with 1 antibiotic is effective for Chlamydia infection. Community-acquired pneumonia and acute exacerbations of chronic bronchitis: 200mg/time x 2 times/day, lasting for 14 days and 10 days. Skin and skin structure infections: 400mg twice daily for 7–14 days. Uncomplicated urinary tract infections: Dose of 100mg/time x 2 times/day, lasting for 7 days. Children over 12 years: Use the same dose as the adult dose.
Other subjects:
Patients with renal impairment: Reduce dose for patients with creatinine clearance (ClCr) < 30mL/min and not on dialysis, use the same dose as normal people, take Safrox once a day. For people on dialysis, use the same dose as normal people, 3 times a week.
4. Undesirable effects when using the drug Safrox
Patients taking Safrox may experience some unwanted side effects.
Common:
Digestive system: Diarrhea, abdominal pain, nausea, vomiting, pseudomembranous colitis; Body and skin: Headache, rash, urticaria, pruritus), genitourinary system (vaginal yeast infection). Uncommon:
Allergic reactions; Anaphylaxis; Athritis; Erythema multiforme; Increased liver enzymes; Hepatitis, transient cholestatic jaundice. Rare:
Blood disorders, eosinophilia; Reversible interstitial nephritis; Agitation, insomnia, confusion, hypertonia, dizziness dizziness. When using Safrox, patients may experience some unwanted effects that are not listed above. Therefore, if you see any side effects, you should immediately notify your doctor for timely treatment. If patients need more information about Safrox, they can consult their doctor or pharmacist.
5. Notes when using Safrox
Patients using Safrox drug should be cautious in the following cases:
Before treatment with Safrox, it is necessary to determine the patient's history of hypersensitivity reactions to Cephalosporins and derivatives of Cephalosporin, Penicillin or other drugs. . Patients need to inform the doctor who treats their history of allergies to drug groups, to avoid unwanted consequences. If a hypersensitivity reaction occurs during treatment with Safrox, the patient should immediately discontinue the drug and initiate anaphylactic therapy appropriate to the patient's condition. Prolonged use of antibiotics, including Safrox, can cause bacterial superinfection, fungal infection or bacterial proliferation, including Clostridium difficile infection associated with diarrhea and pseudomembranous colitis. The efficacy and safety of Safrox have not been established in infants younger than 2 months of age. Pregnancy: There is currently no evidence of Safrox's risk of fetal toxicity or teratogenicity in animals. However, there are no adequate and well-controlled studies on the use of Safrox during pregnancy or childbirth, so it is recommended to use Safrox only under the prescription of a specialist when absolutely necessary. and the benefits outweigh the risks to the fetus. For women who are breastfeeding: Safrox is excreted in small amounts into breast milk, affecting the nursing infant such as changes in the bacteria in the intestines, causing digestive disorders, and interfering with laboratory tests to assess infection. infection when the child has a high fever. Stop breastfeeding in mothers taking Safrox. For people who are driving or operating machinery: Because Safrox can cause headaches and dizziness, it should be used with caution when driving, operating machinery or doing work that requires alertness.
6. Safrox drug interactions
Safrox may interact with the following drug classes. Before using the drug, the patient needs to inform the doctor about the drugs being used to make the treatment process effective and reduce unwanted effects:
H2 antihistamines and antacids can reduce bioavailability. use of Safrox. Probenecid has the potential to decrease the elimination of Safrox. Cephalosporins, including Safrox, may enhance the anticoagulant effect of coumarin derivatives and decrease the contraceptive effect of estrogen. A false-positive reaction to the urine glucose test with Benedict's, Fehling's, or copper sulfate solutions may occur. Olanzapine, Cimetidine, Nizatidine, Ranitidine, Famotidine, Methantheline, Doxepin, Asenapine, Metiamide, Roxatidine acetate may cause a decrease in the absorption of Safrox resulting in decreased serum concentrations and potentially decreased efficacy. Above is important information about Safrox antibiotic. Because Safrox is a prescription drug, patients should not use it on their own, but need to directly contact a doctor or a qualified person to have a suitable prescription to ensure safety for health.
