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Cefpomed has the main ingredient is Cefpodoxime proxetil, a 3rd generation cephalosporin antibiotic. The drug's mechanism of action is to inhibit bacterial cell wall synthesis and cause bacterial lysis. The article will provide some information about the uses, dosage and notes when using Cefpomed.
1. What is Cefpomed?
Cefpomed has the main ingredient Cefpodoxime proxetil (ester of cefpodoxime), a 3rd generation Cephalosporin antibiotic. The drug's mechanism of action is by inhibiting bacterial cell wall synthesis by binding to one or more penicillin-binding protein (PBP), thereby inhibiting peptidoglycan synthesis in the bacterial cell wall, inhibiting cell wall biosynthesis. Therefore, bacteria will be lysed due to the continuous action of enzymes that break down the cell wall.
In general, Cefpodoxime is active against gram-positive cocci such as pneumococci (Streptococcus pneumoniae); Streptococcus (Streptococcus) group A, B, C, G and staphylococcus aureus, S. epidermidis with/without beta-lactamase secretion. However, Cefpodoxime is not effective against methicillin-resistant Staphylococcus aureus (MRSA). Cefpodoxime is also effective against gram-negative cocci and bacilli. The drug is active against commonly pathogenic gram-negative bacteria such as E. coli, Klebsiella, Proteus mirabilis and Citrobacter.
Cefpodoxime proxetil has little antibacterial activity when not hydrolyzed to cefpodoxime. Cefpodoxime proxetil after oral administration is absorbed from the gastrointestinal tract and is broken down by esterases to the active metabolite cefpodoxime. The bioavailability of Cefpodoxime is about 50% and is increased when taken with food. The half-life of Cefpodoxime is 2.1 - 2.8 hours in patients with normal renal function, increasing to 3.5 - 9.8 hours in patients with impaired renal function. Approximately 40% of the drug is bound to plasma proteins. The drug is eliminated unchanged by the kidneys.
2. Uses of Cefpomed
Cefpomed-200 is used to treat mild to moderate bacterial infections of the lower respiratory tract, including acute community-acquired pneumonia caused by susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae (including strains of Streptococcus pneumoniae) produces beta-lactamases); acute exacerbation of chronic bronchitis caused by susceptible strains of S. pneumoniae and H. influenzae or Moraxella catarrhalis, which do not produce beta - lactamase. Treatment of mild to moderate infections of the upper respiratory tract such as pharyngitis, tonsillitis caused by susceptible Streptococcus pyogenes. Cefpodomed also has a role in the treatment of acute otitis media caused by susceptible strains of S. pneumoniae, H. influenzae (including beta-lactamase-producing strains) or B. catarrhalis. Treatment of uncomplicated mild to moderate urinary tract infections (cystitis). A single dose of 200 mg is used to treat acute, uncomplicated gonorrhea. Cefpomed-200 is also used to treat mild to moderate uncomplicated skin and skin tissue infections caused by penicillinase-producing/non-penicillinase-producing Staphylococcus aureus and susceptible strains of Streptococcus pyogenes.
3. Dosage of Cefpomed
Adults:
Upper respiratory tract infections, including tonsillitis and pharyngitis: 100 mg every 12 hours for 10 days. Acute community-acquired pneumonia: 200 mg orally every 12 hours for 14 days. Uncomplicated acute gonococcal infection: a single dose of 200 mg. Uncomplicated urinary tract infections: 100 mg orally every 12 hours for 7 days. Skin and skin structure infections: 400 mg every 12 hours for 7-14 days. Children:
Acute otitis media: dose 10 mg/kg/day (maximum 400 mg/day divided into 2 doses) for 10 days. Pharyngitis and tonsillitis: dose 10 mg/kg/day (maximum 200 mg/day in 2 divided doses) for 10 days.
4. What is the effect of Cefpomed?
Frequency > 10%:
Dermatology: Diaper rash; Gastrointestinal: Diarrhea (infants and toddlers). Frequency 1 to 10%:
Central nervous system: Headache; Dermatology: Skin rash; Gastrointestinal: Diarrhea, nausea, abdominal pain, vomiting; Genitourinary system: Vaginal infections. Frequency <1%:
Anaphylaxis, chest pain, cough, decreased appetite, dizziness, dyspepsia, nosebleeds, itchy eyes, fever, flatulence, flushing, fungal skin infections, hypotension , insomnia, pseudomembranous colitis, tinnitus, vulvovaginal candidiasis, asthenia
5. Contraindications of Cefpomed
Cefpomed is contraindicated in patients who are allergic to cephalosporins and in patients with porphyria.
6. Be careful when using Cefpomed-200
Before starting treatment with Cefpodoxime, carefully inquire about the patient's history of allergy to Cephalosporin antibiotics, penicillins or other drugs. Cefpomed should be used with caution in patients with hypersensitivity to penicillins and impaired renal function. Pregnancy: There are currently no data on the use of cefpodoxime during pregnancy. However, cephalosporins are generally considered safe to use during pregnancy. Lactation: Cefpodoxime is written in breast milk. Because of the potential for serious adverse reactions in the nursing infant, the manufacturer recommends that a decision be made whether to discontinue nursing or to discontinue the drug, depending on the importance of treatment for the mother. In general, antibiotics present in breast milk can cause changes in the intestinal microflora unrelated to the dose, direct effects on the infant's body and the results of bacterial culture if an antibiotic chart is required. when infection is suspected. Cefpomed can cause interactions when used concurrently with certain other drugs. Therefore, patients should inform their doctor of all medications, supplements and vitamins they are taking so that the doctor can consider replacing drugs when necessary. Above is some information about the uses, dosage and notes when using Cefpomed. Patients should be advised not to self-medicate, but should consult a doctor or pharmacist before using.
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