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Medaxetine 1.5mg is a semi-synthetic antibiotic of the second generation Cephalosporin group used to treat a variety of infections caused by bacteria. To ensure effective use, users need to strictly follow the instructions of the doctor, professional pharmacist.
1. What is Medaxetine 1.5mg?
Medaxetine 1.5mg is a semi-synthetic antibiotic of the second generation Cephalosporin group used to treat a variety of infections caused by bacteria. The drug works by inhibiting the synthesis of the bacterial cell wall, making it impossible for the bacteria to grow.
Each Medaxetine 1.5mg vial contains Cefuroxim Sodium equivalent to 1.5g Cefuroxime powder sterile for injection, used intramuscularly or intravenously.
2. What does Medaxetine do?
The antibacterial spectrum of the drug is quite broad and effective against many pathogenic bacteria, including beta-lactamase/cephalosporinase-producing strains of both Gram-negative and Gram-positive bacteria. In addition, the drug is particularly resistant to many beta-lactamase enzymes of bacteria, especially intestinal bacteria.
Cefuroxim ingredients are effective on bacteria such as:
Gram (-): Escherichia coli, Haemophilus influenzae, Klebsiella sp., Bordatella pertussis, Enterobacter sp.,... Gr (+): Staphylococcus aureus , Staphylococcus epidermidis Anaerobic bacteria: Bacteroidesfragilis, Clostridium sp. Cefuroxime can be widely distributed throughout the body, including pleural fluid, sputum, bone, synovial fluid, aqueous humor, and crosses the blood-brain barrier when the meninges are inflamed. In addition, the drug also crosses the placenta and is excreted in breast milk.
The injectable form of the antibiotic Cefuroxime such as Medaxetine 1.5mg is usually only prescribed by doctors in cases of severe infections or complications of the following conditions:
Infections in the respiratory tract: bronchitis acute and chronic, infectious bronchiectasis, bacterial pneumonia, lung abscess and chest infection after surgery. Ear, nose and throat infections: tonsillitis, sinusitis, pharyngitis. Urinary tract and genital tract infections: acute and chronic pyelonephritis, cystitis and asymptomatic bacteriuria, pelvic inflammatory disease. Soft tissue infections: cellulitis, erysipelas, peritonitis and wound infections. Bone and joint infections: septic arthritis, osteomyelitis. Other infections: sepsis and meningitis. Prophylaxis in cases of high risk of infection such as abdominal, pelvic, orthopedic, cardiac, pulmonary, esophageal, and vascular surgery.
3. Usage and dosage of Medaxetine 1.5mg
Medaxetine injection powder 1.5mg is usually administered by slow intravenous infusion or intravenous injection.
For intravenous administration, mix 1 vial of Medaxetine 1.5mg with 15ml of distilled water for injection, then shake well until a clear solution is obtained. For slow intravenous infusion, mix 1 vial with 50ml of one of the following suitable solutions: NaCl 0.9%; Dextrose 5%; Dextrose 10%; Ringer's solution, and Lactated Ringers solution. The resulting solution is infused over at least 30 minutes. The drug should be used immediately after reconstitution. The usual dosage for adults is 1 vial of 1.5g intravenously every 6 to 8 hours. In children from 1 month to 18 years old, 20 mg/kg each time (maximum 750 mg/time), every 8 hours. When necessary, the dose can be increased to 50-60 mg/kg/time (maximum 1.5 g each time), 6 to 8 hours apart. For meningitis caused by susceptible strains of bacteria: Adults intravenously at a dose of 3 g every 8 hours. Children from 3 months of age, intravenous dose of 200-240 mg/kg/day, divided into 3 or 4 small doses, every 6-8 hours. Then, depending on the clinical response, adjust the dose accordingly.
4. Special notes when using Medaxetine 1.5mg
Special notes when using Medaxetine 1.5mg are:
Medaxetine is contraindicated in people who are allergic to Cephalosporin antibiotics. Before using the drug, it is necessary to note some medical history such as allergy to penicillin or any other drug, or kidney disease, gastrointestinal disease (GI especially colitis), liver disease, nutrition poor maintenance. Be careful when using the drug in pregnant or lactating women. Give your doctor a list of all the medications you are taking or plan to take including prescription and over-the-counter medicines, vitamins, supplements, and herbal products. Especially the following: anticoagulants such as Warfarin, Cimetidine, diuretics, Famotidine, Nizatidine, Omeprazole, Pantoprazole, Probenecid and Ranitidine. In case of drug overdose, it can cause nausea, vomiting, and diarrhea or increased neuromuscular excitability and convulsions,... When performing treatment, it is necessary to consider the possibility of overdose of many drugs. Drugs, drug interactions, and unusual pharmacokinetics in patients. Drugs can be removed from the blood by hemodialysis, but most treatment is supportive or symptomatic, such as: paying attention to protecting the patient's airways, helping to ventilate and administer fluids, stopping the drug or/ and use anticonvulsant therapy if there is a convulsion,... Store the vial of powder for injection at 15 - 30 degrees Celsius, protect from light.
5. Undesirable effects of Medaxetine 1.5mg
Unwanted effects may be encountered when using Medaxetine as follows:
Local burning pain and/or thrombophlebitis at the injection site. Diarrhea. Skin rash. Anaphylactic reaction Candida infection. Eosinophilia, leukopenia, neutropenia Nausea, vomiting. Hives, itching. Fever Hemolytic anemia. Pseudomembranous colitis. Erythema multiforme Stevens-Johnson syndrome Toxic epidermal necrolysis. Cholestatic jaundice, increased AST, ALT Acute renal failure and interstitial nephritis. Seizures Excitement. This is not a complete list of Medaxetine side effects, some other undesirable effects may still occur. Therefore, tell your doctor if you notice anything unusual that worries you.
Medaxetine 1.5mg is a semi-synthetic antibiotic of the second generation Cephalosporin group used to treat a variety of infections caused by bacteria. To ensure effective use, users need to strictly follow the instructions of the doctor, professional pharmacist.
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