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Lezra is indicated for the treatment and prevention of breast cancer recurrence in postmenopausal women. So how to use Lezra? Let's find out the necessary information about Lezra through the article below.1. What is Lezra drug?
Lezra medicine contains the ingredient Letrozole 2.5mg and other excipients just enough provided by the manufacturer. The drug is prepared in the form of film-coated tablets, packed in a box of 3 blisters, each blister has 10 tablets.
2. What does Lezra do?
Lezra is indicated for the treatment of the following cases:
Treatment of advanced breast cancer in postmenopausal women who have failed treatment with Tamoxifen or other anti-oestrogens. Treatment of early breast cancer in postmenopausal women who have been previously treated with Tamoxifen. Preoperative mastectomy for postmenopausal women with hormone receptor-positive breast cancer. On the other hand, Lezra drug is contraindicated in the following cases:
Allergy to the active ingredient Letrozole or other excipients in the composition of the drug. Pre-menopausal women, lactating women and pregnant women. Patients with severe liver failure. Do not use this drug before surgery if receptor status is negative or unknown.
3. Dosage and way of taking Lezra
Lezra drug is prepared in the form of film-coated tablets, used orally. The drug should be taken with a full glass of water, the patient can take it on an empty stomach or full.
Lezra is only for adults, here are the recommended doses for adults and the elderly:
Use at a dose of 2.5mg / time / day. In adjuvant therapy, Lezra should be administered continuously for 5 years or until tumor recurrence, whichever comes first. After the standard course of Tamoxifen, treatment with Lezra should be continued for 3 years or until the tumor recurs, whichever comes first. Since there are insufficient data on the use of Lezra, there is no optimal duration of use. In patients with metastases, Lezra should be continued until tumor progression becomes evident. Preoperative treatment: Regularly check the progress of the disease to consider the appropriate treatment dose. For the elderly, patients with mild or moderate hepatic impairment: Use at the same dose as the adult dose, no need to adjust the dose. For patients with renal impairment with creatinine clearance >10ml/min, no adjustment of the daily dose is required. Note: This dosage is only recommended by the manufacturer. Depending on the medical condition of each patient, the doctor will prescribe the appropriate dose. Therefore, patients need to follow the doctor's instructions, do not change the dose or give the medicine to others when having similar symptoms.
4. Side effects of the drug Lezra
The doctor always considers the benefit that Lezra brings to the patient and the possible risk of side effects to prescribe the appropriate medication. Patients must follow the doctor's instructions to limit the occurrence of unwanted effects. Lezra is generally well tolerated, with side effects usually mild or moderate, mostly due to a lack of estrogen.
Some possible side effects during taking the drug are as follows:
Common:
Joint pain, facial flushing, loss of appetite, appetite, increased serum cholesterol, neurasthenia, headache, dizziness , nausea, vomiting, gastrointestinal disturbances, constipation, diarrhea, hair loss, increased sweating, rash, muscle pain, bone pain, osteoporosis, fracture, fatigue, peripheral edema, increased weigh. Uncommon:
Urinary tract infection, breast tumor pain, edema, fatigue, insomnia, memory loss, tactile disturbance, taste disturbance, cerebrovascular accident, palpitations, tachycardia, inflammation venous thrombosis, high blood pressure, myocardial infarction, shortness of breath, cough, abdominal pain, glossitis, dry mouth, dry skin, urticaria, arthritis, weight loss, vaginal bleeding. Rare:
Pulmonary vascular occlusion, thrombosis, cerebral ischemia. In the event that a patient experiences any of the above effects or unusual side effects that are suspected to be due to the drug, the patient should immediately notify the treating physician for advice.
5. Lezra drug interactions
Tell the doctor about all the drugs the patient is using such as prescription drugs, over-the-counter drugs, functional foods, herbs... to limit interactions when combining drugs during treatment. treatment course.
Some interactions may occur when Lezra is combined with other drugs below:
Clinically, Lezra drug has no significant interaction with Cimetidine, Benzodiazepine, Barbiturates, non-steroidal anti-inflammatory drugs, Paracetamol, Furosemide , Omeprazole. There is no experience with the use of Lezra in combination with other antineoplastic agents.
6. Notes when using Lezra
Some notes when patients take Lezra medicine are as follows:
This drug should not be used in pediatric patients, because efficacy and safety have not been evaluated in clinical studies. There are no data on the use of Lezra in male breast cancers. Lezra should be used with caution in patients with creatinine clearance less than 10 ml/min. The drug Lezra has the ability to drastically reduce the amount of estrogen, so there is a risk of a sharp decrease in bone mineral in the patient. Therefore, before treatment with this drug, women with osteoporosis or at risk of osteoporosis should have their bone density checked. Contraception should be used when using Lezra in women who are near menopause or have just gone through menopause. When using Lezra, patients often feel tired and dizzy, sometimes drowsy, so caution should be exercised when driving or operating machinery. Above is information about the uses, dosage and precautions when using Lezra. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Lezra exactly as directed by your doctor.
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