Uses of Korucal

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Korucal medicine has ingredients containing vitamin D3 and calcium that are involved in the process of bone formation and regulation of calcium levels. In addition, these components also participate in the process of epithelial cell differentiation. However, the drug may not be used for people with hypercalcemia syndrome or calcium stones... So when using the drug, you need to be consulted and prescribed by a doctor.

1. Pharmacodynamics and pharmacokinetics of the drug Korucal

Vitamin D is used to supplement cases of vitamin D deficiency when vitamin D will increase calcium absorption in the intestinal tract. For the elderly, the optimal amount of vitamin D can be from 500 to 1000 IU/day. There is also calcium to supplement cases of calcium deficiency in the diet. The usual calcium requirement in adults is usually 1500mg/day. Both vitamin D and calcium can help treat secondary hyperparathyroidism in adults.
1.1 Ability to absorb calcium carbonate Calcium when entering the body will be absorbed in the gastrointestinal tract thanks to the active transport process along with passive diffusion, calcium will be actively absorbed in the duodenum and in the jejunum. colon. The remaining small amount of calcium is absorbed in the periphery of the small intestine. The extent to which calcium is absorbed in the body will depend on many factors such as whether calcium is dissolved or oxidized. The process of absorbing calcium will be different depending on age. However, the time when calcium absorption is highest when you are a baby accounts for about 60% and this number will decrease in prepubertal children to only about 28%, and the head increases again at the beginning. of puberty. In addition, calcium absorption in young people is about 25%. Although calcium absorption may increase during the last two stages of pregnancy. The absorption of calcium will be slowed down by stable calcium ions such as calcium oxalate, phytate... or may be precipitated by fatty acids or may be due to complexes of calcium ions. However, in the intestinal pH environment between 5 and 7, it is possible to maximize the decomposition and separation of calcium complexes.
Calcium, after being put into the body, it will first go into the extracellular fluid of cells and quickly bind closely with bone cells. However, the formation of bone cells will not be stimulated by calcium utilization. However, bones contain up to 99% of the body's calcium, and the remaining 1% is distributed between the intracellular and extracellular fluids. Normal blood calcium concentration ranges from 9 to 10.4ml/dl, but only ionized calcium has biological effects on the body. Blood calcium levels are not an accurate indicator of the total amount of calcium in the body. Because the amount of calcium in the body can decrease when the blood calcium is increased, and conversely, hypocalcemia can occur even when the total body calcium is increased.
Of the total calcium in the blood, the content of calcium in the ionized form accounts for 50% and only 5% of calcium is in the complex form such as phosphate, citrate... In addition, the remaining 45% of calcium in the blood will be carried out continuously. bound to plasma proteins. The calcium concentration in the cerebrospinal fluid can account for about 50% of the calcium concentration in the blood and this parameter indicates the ionization of the plasma calcium concentration. When calcium crosses the placenta, the concentration in the blood of the fetus is higher than that of the mother. And calcium can also be passed through breast milk.
The amount of calcium ions will be excreted in the urine and filtered at the glomerulus. However, a certain amount can also be reabsorbed. This reabsorption will take place in the renal tubules and the content is quite large, up to 98% of Ca2+ ions return to the circulation. This calcium reabsorption is strongly regulated by parathyroid hormone and also influenced by Na+ filtration. However, in the presence of anions will not perform reabsorption. Calcium is excreted quite a lot in milk during lactation, and only a small amount of calcium will be excreted through sweat and feces.

1.2 Absorption of cholecalciferol - vitamin D Similar to calcium, vitamin D will be absorbed through the intestinal mucosa by bile salts and lipids. Because vitamin D belongs to the group of fat-soluble vitamins, when vitamin D binds to microscopic chyme, it is absorbed through the lymphatic system. About 80% of the dose of vitamin D that can be absorbed into the body is made through this mechanism and mainly occurs in the small intestine. Vitamin D after being absorbed into the blood and entering the body will be thanks to the Lymphatic chyme is bound to a special alpha globulin - which binds vitamin D to proteins. The hydroxylated metabolites of cholecalciferol - vitamin D are co-bound with alpha globulin, 25 cholecalciferol is stored in fat and muscle over time. When vitamin D enters the circulatory system from the lymph to the ducts in the chest or from the skin, it accumulates in the liver for several hours. Once in the liver, vitamin D is converted into microparticles that produce their 25 hydroxy by the enzyme vitamin D 25 hydroxylase. The activity of the vitamin D 25 hydroxylase enzyme will be in the liver due to the concentration of vitamin D and its metabolites. Furthermore, the increase in 25 hydroxy metabolites in the systemic circulation following sun exposure or vitamin intake is related to vitamin D accumulation or ingestion. Vitamin D and its metabolites may be excreted mainly via bile and feces. Only a small amount of vitamin D is excreted in the urine. And with some vitamin D can be passed into milk.

2. Uses, dosage and usage of Korucal

Korucal medicine is indicated for use in the case of calcium and vitamin D supplementation with children in the growth period to help the bone and teeth system develop well. At the same time, the use of Korucal medicine helps children prevent rickets. Or it can be used by pregnant and lactating women. Or for older people to help prevent and treat osteoporosis due to calcium loss with increasing age or calcium loss after menopause.
Korucal is taken orally and taken with meals. For adults can use one tablet once and use twice a day. For children to treat rickets, it should be supplemented early and each month can use a dose of about 5mg, equivalent to 20000 IU, or 10mg equivalent to 400000IU for children with little sun exposure or dark skin. color. With the treatment of convulsions due to calcium deficiency, it is possible to use the same dose as the indicated dose for rickets and at the same time it is necessary to combine the addition of calcium salts.
The above dosages are for reference only. If you need to use the drug, you should see a doctor and use it according to the indications suitable for your individual condition. Avoid self-medication that can cause adverse health consequences.
In case of overdose of Korucal, you should stop using it and notify your doctor immediately. In the event of an emergency, the patient should be taken to the nearest medical facility.
When you miss a dose, try to use the missed dose as soon as possible. However, when it is almost time for your next dose, you can skip the missed dose and take your next dose.

3. Some unwanted side effects when using Korucal

Korucal drug may be contraindicated in some cases such as patients with hypercalcemia, kidney stones, or high calcium in the urine or possibly severe kidney failure, children under 12 months. Korucal medicine can cause some unwanted side effects such as nausea, diarrhea, low blood pressure, red face, irregular heartbeat, rash... Those who experience these signs should Stop using the medicine and contact your doctor.
Korucal medicine may interact with some other drug ingredients such as phosphate or calcium salts, or tetracyclines ... or green and black tea because they contain tannic acid...
Be careful about Korucal to achieve results good results when used and minimize the possible side effects.

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