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Hepa merz drug is a drug used to treat people with liver disease, typically symptomatic treatment of cirrhosis, hepatic coma, hepatitis,... Learn about its uses, usage, and hepatitis with Vinmec. Things to note when using Hepa merz in the article below.
1. What is Hepa merz?
The drug Hepa Merz of the company B. Braun Melsungen AG with the main ingredient is L - orthinin - L - aspartate. The drug is prepared in the form of a concentrated solution and infusion. Packing specification box of 5 tubes, 10 ml each.
This drug is used to treat some acute and chronic liver diseases, the pre-coma (cognitive disorder). In particular, the drug is most commonly used to relieve symptoms in people with advanced liver disease who have neurological complications (hepatic coma).
2. The effect of the active ingredient L-ornithine-L-aspartate in the formula
L-ornithine-L-aspartate (LOLA) is a chemical. It is made up of two amino acids Ornithine and Aspartic Acid, which are broken down in the body to provide aspartic acid and ornithine.
Mechanism of action of LOLA: Increases the concentration of Ornithine and Aspartic acid in the body. These amino acids will help reduce the level of free Ammonia in the blood, thereby helping to detoxify the liver effectively.
3. Indications of the drug Hepa merz
Indications for use of Hepa merz include:
Lowering free ammonia in the early stages of neurological complications (hepatic-brain coma), cognitive disorders (signs of pre-coma). In addition, reduces the symptoms of hepatic encephalopathy in people with cirrhosis. Indicated as supportive treatment for patients with liver dysfunction, acute or chronic liver disease such as cirrhosis, hepatitis, fatty liver.
4. How to use the drug
Hepa merz drug is used for intravenous infusion. Dosage is indicated according to the doctor's prescription and according to specific patient groups:
For patients with acute hepatitis: Dosage, 1-2 ampoules per day. For patients with chronic hepatitis, cirrhosis: Dosage, 2-4 ampoules per day. For more severe patients, the dose can be increased, but should be consulted with the doctor. For patients with pre-coma, hepatic coma: Dosage, using 8 ampoules per day depends on the specific condition of the patient. Regarding the baud rate, the maximum can be 5g/hour. Maximum dose of 6 ampoules/500ml of infusion. Note:
In case of high dose infusion, the concentration of urea in the plasma and urine of the patient must be monitored.
In case of overdose, missed dose you can handle as follows:
Overdose: There have not been any cases of overdose when using Hepa merz intravenously. Therefore, if you have any unusual symptoms, you should immediately notify your doctor for timely treatment. Missed dose: If you miss a dose, do not double your dose on your own, but consult your doctor in case of missed dose. When using the drug, some side effects may occur such as skin allergies, nausea, vomiting. However, these side effects are very rare (incidence less than 0.1%). When experiencing any unusual reactions, you should immediately notify your doctor or pharmacist for monitoring and treatment.
Before using the drug, check the integrity of the packaging, the clarity and color of the solution, the expiry date of the drug. Read the instructions for use that come with the medicine before using it.
5. Contraindications to the drug Hepa merz
Do not use Hepa merz for the following subjects:
People with impaired renal function, when the serum creatinine concentration exceeds 3 mg / 100 ml.. People who are sensitive or at risk of allergies to any of these drugs. any ingredient of the drug. Use of Hepa merz in pregnant women and nursing mothers: There are not enough data on the use of this drug in pregnant women or nursing mothers. Therefore, you should consult your doctor before taking the medicine. People who drive and use machines: There are no precise studies on the effects of Hepa merz on drivers and operators. However, you should also be very careful when using it.
6. Hepa merz drug interactions
Regarding the phenomenon of drug interactions, currently, there have not been any reports of interactions when used simultaneously with other drugs or foods. However, to ensure safety during the use of Hepa merz, patients should provide their doctor with a list of medications or foods they are taking.
7. Note how to store when using medicine
The most suitable storage conditions of Hepa merz medicine: Store in a dry place, away from moisture. Avoid direct sunlight, temperature should not exceed 30oC. Medicines should be stored in the original packaging. Hepa merz drug belongs to the group of drugs for the treatment of liver disease with indicated doses depending on age and disease status. Drug users need to absolutely adhere to the dose prescribed by the doctor to ensure the safety and effectiveness of treatment, and to limit dangerous side effects.
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