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In patients with diabetes, Metformin has the effect of reducing the rise in blood sugar but does not cause hypoglycemia. Therefore, Metformin is considered an appropriate anti-hyperglycaemic drug for new cases of the disease, this active ingredient is now present in the drug product Glucofine 1000mg.
1. What are the effects of Glucofine 1000mg?
Ingredients in each Glucofine 1000mg film-coated tablet contains the main active ingredient: Metformin hydrochloride with a concentration of 1000mg and a system of excipients such as: Povidon K30, Magnesium stearate, Colloidal Silicon dioxide A200, Hydroxypropyl methylcellulose 15cP, Hydroxypropyl methylcellulose 6cP, Polyethylene glycol 6000.
Glucofine 1000mg for the treatment of type 2 diabetes:
Glucofine 1000mg monotherapy in combination with diet and exercise; Indicated when hyperglycemia cannot be controlled by diet alone; Metformin is the drug of choice for diabetes treatment in overweight patients. Glucofine 1000mg can be used concurrently with one or more other oral antidiabetic agents, or with an insulin regimen, when diet and metformin alone cannot be controlled. The patient's blood sugar is within the target range.
2. Dosage of Glucofine 1000mg
2.1. The recommended dose of Metformin The starting dose for patients who have never or are not using metformin is 500 mg once daily, administered orally. If the patient does not experience gastrointestinal adverse reactions with the initial dose, it may be necessary to increase the dose by 500 mg at intervals of 1 to 2 weeks. Dosage of Metformin will be considered and adjusted on an individual basis based on efficacy and tolerability. Be careful not to exceed the maximum recommended dose of 2000mg/day. Accordingly, Glucofine 1000mg is used in cases where the patient needs to use a high dose of Metformin (1000 - 2000 mg / day), after the initial dose of 500 mg or 850 mg, 2-3 times / day.
2.2. Dosage of Glucofine 1000mg for adults with normal renal function Monotherapy with Glucofine 1000mg or in combination with other oral antidiabetic drugs:
Use Glucofine 1000mg tablets at a dose: 1 tablet/time, maximum 2 tablets /day divided into 2 doses; When switching from another oral antidiabetic to Metformin, the patient should first stop taking the previously taken antidiabetic drug, then initiate a starting dose of 500 mg or 850 mg of Metformin, 2 - 3 times/day (recommended Glucofine 500mg or 850mg Glucofine tablets). Combination of Glucofine with insulin: Metformin can be combined with insulin to achieve better glycemic control, starting with Metformin 500mg or 850mg, 2-3 times a day, the dose of insulin is adjusted based on the results of the control. Check the blood sugar of each individual patient.
2.3. Glucofine 1000mg dose for patients with renal impairment Glucofine 1000mg has the potential to decrease renal function in the elderly, so the dose of Metformin should be adjusted based on the patient's renal function.
2.4. Metformin Pediatric Dosage Glucofine 1000mg monotherapy or in combination with insulin:
Glucofine 1000mg can be used in adolescents and children 10 years of age and older. The usual starting dose of Metformin is 500mg or 850mg of metformin, once daily, taken with or after a meal. After 10 to 15 days, metformin should be adjusted based on blood glucose levels and gradually increased to improve gastrointestinal tolerance. The maximum dose of metformin is 2000mg/day, divided into 2 - 3 times. 2.5. Glucofine 1000mg dose for patients with renal impairment Assess glomerular filtration rate (GFR) prior to initiating Glucofine 1000mg and at least annually. Accordingly, the total maximum daily dose (divided into 2-3 times/day) of Metformin according to the patient's glomerular filtration rate is as follows:
GFR = 60-89 (mL/min/1.73 m2): maximum total dose daily 2000mg (divided into 2-3 times/day); GFR = 45-59 (mL/min/1.73 m2): maximum total daily dose of 2000mg (divided into 2 - 3 times/day); GFR = 30-44 (mL/min/1.73 m2): total maximum daily dose of 1000mg (divided into 2 - 3 times/day); GFR < 30 (mL/min/1.73 m2): Contraindicated. 2.6. How to take Glucofine 1000mg Take Glucofine 1000mg orally, take the drug during or after meals. In case you forget to take a dose of Glucofine 1000mg: Take it as soon as you remember. If it is almost time for the next dose of Glucofine 1000mg, skip the missed dose of Glucofine 1000mg and take the next dose at the usual time, taking care not to take a double dose to make up for the missed dose. In case you take too many Glucofine 1000mg tablets, see a doctor immediately or go to the nearest hospital's emergency department.
3. Contraindications of Glucofine 1000mg
Patients with a history of hypersensitivity to Metformin or any other ingredient of Glucofine 1000mg; Patients with acute catabolism, severe infections (requiring insulin therapy); Severe renal failure (eGFR less than 30 mL/min/1.73 m2); Acute or chronic metabolic acidosis, including diabetic ketoacidosis; Heart or respiratory failure, recent myocardial infarction, shock. Dehydration, septic shock; Patients receiving intravenous administration of iodinated contrast agents (only Glucofine 1000mg should be reintroduced when renal function returns to normal); Liver failure, acute alcohol intoxication, alcoholism; Stop Glucofine 1000mg in the morning before surgery and restart Glucofine 1000mg when kidney function returns to normal; Pregnant women: mandatory insulin treatment, do not use Glucofine 1000mg; Breastfeeding women; Type 1 diabetes; Diabetic pre-coma.
4. Side effects of Glucofine 1000mg
The most common undesirable effects of Glucofine 1000mg include: Nausea, vomiting, diarrhea, abdominal pain, loss of appetite and these signs will resolve spontaneously in most cases. To prevent this, it is recommended to divide the dose of Metformin into 2-3 times/day and increase the dose gradually. .
Very rare side effects of Glucofine 1000mg :
Lactic acidosis, reduced absorption of vitamin B12, decreased vitamin B12 in plasma may affect patients with megaloblastic anemia; Abnormal liver function indicators or hepatitis will resolve spontaneously when the drug is stopped; Skin reactions such as red rash, itching, urticaria. Instructions on how to handle side effects of Glucofine 1000mg:
Take metformin with meals, increase the dose gradually; Hypoglycaemia did not occur with Metformin alone, but hypoglycaemic events occurred in combination with other factors (eg, sulfonylurea, alcohol); With long-term use of Glucofine 1000mg, there may be a risk of decreased absorption of vitamin B12, which can be treated with vitamin B12 supplements; Lactic acidosis rarely occurs with Glucofine 1000mg but can be fatal at a high rate; Discontinue Glucofine 1000mg if serum lactate levels exceed 5 mmol/L. Renal or hepatic failure is a mandatory indication to discontinue Glucofine 1000mg; Do not use or limit alcohol intake; In patients with prolonged fasting or being treated with a very low calorie diet, it is best to discontinue Glucofine 1000mg. Glucofine 1000mg is only used when prescribed by a doctor, avoiding arbitrary drug use will cause adverse health effects. When experiencing any unusual symptoms suspected of Glucofine 1000mg should also notify the doctor.
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