Use of Duphaston in patients with polycystic ovary syndrome

This article has been reviewed with the expertise of Dr. Le Hong Lien, Specialist I in Obstetrics and Gynecology, Vinmec Central Park International General Hospital.


Polycystic ovary syndrome (PCOS) tends to impact various areas of the body, including the reproductive system. It increases the risk of gynecological disorders, type 2 diabetes, and cardiovascular diseases. Duphaston is commonly prescribed by doctors to assist in managing PCOS.

1. Understanding Polycystic Ovary Syndrome (PCOS)


Polycystic ovary syndrome (PCOS) is one of the leading causes of infertility in women. PCOS refers to an abnormal increase in androgen levels in a woman's body. Elevated androgen disrupt the development of ovarian follicles, forming multiple small follicles that cannot mature. As a result, the eggs fail to develop properly and do not reach maturity, causing anovulation (lack of ovulation).

Women with PCOS often experience menstrual irregularities or even amenorrhea. The signs and symptoms of PCOS include:

Irregular menstrual cycles, with either absent or infrequent periods, and the menstrual flow may be light or heavy.
Infertility.
Weight gain, obesity, or the presence of acne.
Excessive hair growth on the face, chest, abdomen, or thighs.
Oily skin or thick, hyperpigmented skin in areas with skin folds.
PCOS tends to affect multiple organs in the body, particularly the reproductive system. It increases the risk of infertility, gynecological diseases, type 2 diabetes, and cardiovascular conditions. Besides, women with PCOS are at higher risk of endometrial hyperplasia, which causes the uterine lining to thicken and increases the risk of endometrial cancer.

2. Using Duphaston in Patients with PCOS


Duphaston is a prescription medication that belongs to the group of hormonal drugs. It is also used to help women maintain pregnancy or increase fertility. Duphaston should only be used when prescribed by a specialist for a specific purpose.
The active ingredient in Duphaston is Dydrogesterone, with a dosage of 10mg. Dydrogesterone is a hormone similar to progesterone, a natural hormone in the body. Moreover, Duphaston contains other excipients such as lactose monohydrate, titanium dioxide (E171), and magnesium stearate.
With its active ingredients, Duphaston is prescribed to treat polycystic ovary syndrome, endometriosis, or other disorders related to reduced progesterone levels, which often lead to irregular menstruation. It is also used for women suffering from infertility or those experiencing recurrent miscarriage caused by luteal phase insufficiency.
For women with irregular menstrual cycles, the question arises: How long does it take for Duphaston to regulate the menstrual cycle ? After taking Duphaston for 10-14 days, the medication typically helps to normalize the menstrual cycle.

3. Can Duphaston be taken before pregnancy?

Duphaston helps stabilize the menstrual cycle, allowing women to predict ovulation and plan for conception. Therefore, it is possible to take Duphaston before pregnancy.

In addition, Duphaston can be used during pregnancy to prevent or treat the threat of miscarriage. However, Duphaston should not be used during pregnancy without a doctor's prescription. If any abnormal symptoms occur, seek medical attention promptly.

 

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