The effect of the drug Daktarin

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Daktarin drug with the main ingredient is Miconazole, an active ingredient with antifungal function against common ringworm and yeast. Besides, the drug also has antibacterial activity against some other bacilli and cocci.

1. What is Daktarin pharma?

The main ingredient with antifungal activity of Daktarin is Miconazole. This is a fairly strong antifungal active ingredient of the Imidazole group.
The mechanism of action of Miconazole is to inhibit the biosynthesis of ergosterol in fungi, changing the lipid composition of the fungal cell membrane. Due to the change in the structure of this lipid envelope, the fungal cells are necrotic and gradually die.
2. What are the effects of Daktarin? Active ingredient Miconazole is a synthetic imidazole with antifungal activity against Candida, Coccidioides, Epidermophyton, Histoplasma, Paracoccidioides, Phialophora, Pseudallescheria and Trichophyton. Miconazole is also active against gram-positive bacteria.
Daktarin is indicated in the treatment of the following pathologies:
Treatment of candidiasis in children and adults; Prophylactic treatment of Candida infections in the oral cavity, pharynx and gastrointestinal tract; Good efficacy in the treatment of diseases caused by infection with certain strains of Gram-positive bacteria.

3. Undesirable effects of the drug Daktarin

3.1. Due to the structure of Daktarin is a thick gel, it can cause suffocation for babies, especially between the ages of 4 months and 2 years old. To limit the risk of this situation, parents should note when using Daktarin for children:
Do not apply the drug gel deep into the baby's throat; In each use of Daktarin, parents should divide the amount of gel needed into several small parts to slowly apply the medicine to their children; Watch your baby carefully for any signs of choking; Do not apply gel to the mother's nipple to treat fungus in case the mother is still breastfeeding. 3.2. Gastrointestinal disturbances This is considered the most common undesirable effect of oral antifungal drug Daktarin. Signs of common digestive disorders are:
Dry mouth ; Nausea, vomiting; Increased risk of bleeding; 3.3. Miconazole - the main active ingredient in Daktarin has the effect of inhibiting drugs that are metabolised via the CYP3A4 and CYP2C9 enzyme systems. As a result, Daktarin potentiates and/or prolongs the effects of inhibitory drugs, including adverse events.
To prevent these interactions, it is necessary to avoid using Daktarin for oral thrush while taking drugs metabolised via CYP3A4 and CYP2C9. If still used, it is necessary to reduce the dose of the drug and monitor the drug concentration in the blood plasma to adjust the dose accordingly.
3.4. Use caution when dealing with large lesions, long-term use Imidazole antifungals are often more toxic than triazoles. The reason is that the selectivity on enzymes of fungal and human cells is not high. The human enzyme 14-α-demethylase is involved in the synthesis of cholesterol - the source of sex hormones. When the drug works, it will cause inhibition of the bacterial enzyme, at the same time it also inhibits this enzyme of the body. Since then, when using Daktarin, it will cause inhibition of adrenal steroid synthesis, causing unwanted effects if used for a long time or absorbed too much.

4. How to use Daktarin

4.1. How to use Daktarin for oral thrush: For infants from 4-24 months old:
Take about 1.25ml of Daktarin gel (about 1/4 teaspoon), absorb the gel into a clean tongue swab or finger to apply. to the fungal area. Apply the drug 4 times a day after meals. For children 2 years and older and adults:
Take about 2.5ml Daktarin gel (about 1/2 teaspoon), soak the gel in a clean tongue gauze or finger to apply to the affected area. Apply the drug 4 times a day after meals. In case you forget to take a dose, use it as soon as possible. However, if the dosing interval is close to the next dose, skip the missed dose and take your next dose at the scheduled time. Do not use the medicine in double the prescribed dose.
4.2. Some notes when using Daktarin to treat oral thrush You use your fingers to wrap gauze, touch your oral cavity and keep Daktarin in your mouth for as long as possible. You can use a clean finger to drop the medicine; If you are wearing dentures, you need to remove it at bedtime and rub medicine on the denture to prevent infection; You need to note taking Daktarin after eating and not taking more than the amount prescribed by the doctor; When using Daktarin for young children or children 4 months of age or older, you need to avoid letting the medicine choke the baby by putting the medicine in front of the mouth; Avoid applying medicated gel deep into the throat, especially if the object is a baby because it can cause choking; Do not swallow the gel immediately after application and try to keep the gel in the mouth for as long as possible; The treatment should be continued for at least 1 week after the signs of the disease have disappeared; In case of an overdose of Daktarin, you may experience vomiting and diarrhea.

5. Daktarin drug interactions

Note when using Daktarin with the following drugs:
Phenytoin; Ergotamine; Triazolam and Midazolam taken orally; HIV protease inhibitors, such as saquinavir; Oral anticoagulants such as Warfarin ; Oral hypoglycemic drugs such as Sulfonylurea; Anticancer drugs or agents such as Vinca alkaloids, Busulfan and Docetaxel; Immunosuppressive drugs: Tacrolimus, Cyclosporine, Sirolimus; HMG-CoA reductase inhibitors such as Simvastatin, Atorvastatin, Lovastatin...; Substances that prolong the QT interval. Examples include Astemizol, Mizolastine, Cisaprid, Dofetilide, Pimozide, Quinidin and Terfenadin; Other disease-modifying drugs; Food you are taking, and alcoholic beverages such as alcohol and tobacco can interact with certain medications. You should consult your doctor about the use of drugs with food, alcohol and tobacco.

6. Those who need to be careful when using Daktarin

Daktarin is contraindicated for the following subjects:
Infants under 4 months old or children over 4 months old have had an incomplete swallowing reflex; People with liver dysfunction; People who are taking drugs that are metabolized by the CYP3A4 enzyme: Medicines to treat dyslipidemia (cause HMG-CoA reductase enzyme inhibition) such as Simvastatin and Lovastatin. Drugs with sedative effects, causing drowsiness such as Triazolam and Midazolam. The drug contains the active ingredient Ergot Alkaloids. Active substances that prolong the QT interval such as Astemizole, Cisapride, Dofetilide, Mizolastine, Pimozide, Quinidine, Sertindole and Terfenadine. Daktarin should be used with caution in the following cases:
Infants and young children (from 4 months to 2 years): Monitor the health of the child while taking the drug to ensure that Daktarin gel does not clog the neck. throat and choking the baby; Women in pregnancy: There are no adequate clinical studies on the side effects of this drug for this population. Therefore, the use of Daktarin in pregnant women should be avoided if possible; Breast-feeding: There are currently no studies on whether Daktarin is excreted in breast milk and affects the baby. Therefore, use in lactating women should be done with extreme caution after considering the benefits and risks of taking the drug.

7. How to store Daktarin

You should store Daktarin at room temperature, away from moisture and direct sunlight; You should not store the medicine in humid places such as in the bathroom or the freezer compartment of the refrigerator; Each drug or medicinal herb may have different preservation methods. You need to carefully read the storage instructions on the product packaging or consult your pharmacist; Keep medicines out of reach of children and household pets; You do not throw medication down the toilet or plumbing unless specifically asked to; You should dispose of Daktarin properly when it has expired or is no longer needed. In summary, Daktarin has antifungal function against common ringworm and yeast. To ensure safety and effectiveness, you need to use the medicine exactly as prescribed by your doctor or pharmacist.

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