Uses of Endix-g

This is an automatically translated article.

Fungal skin infections or inflammatory skin diseases can cause a lot of discomfort for the patient. This requires the use of appropriate topical products, such as Endix-G topical products. So what is Endix-G and how should it be used?

1. What is Endix-g topical?

Endix-G drug is a product of Phil Inter Pharma, the ingredients include the active ingredients Econazole nitrate, Triamcinolone acetonide and Gentamicin sulfate. Endix G is an antifungal medication.
Endix-G drug is made in the form of a topical cream, the package includes 1 tube of 10 grams in each box.

2. Uses of Endix-G topical

Some common indications of Endix G include:
Atopic dermatitis, including eczema, simple dermatitis, diaper dermatitis...; Trichophyton infection in tinea versicolor, trunk skin, facial skin, scalp or tinea pedis; Wandering ; Candida infection of the skin; Skin infections caused by strains of bacteria sensitive to the antibiotic Gentamicin.

3. Pharmacodynamics and pharmacokinetics of Endix-G

Endix-G is considered a well-absorbed antifungal drug, the ingredients include antifungal drugs, antibiotics and corticosteroids:
The ingredient Econazole nitrate acetonide in the drug Endix-G is a broad-spectrum antifungal active with the ability to treat fungal infections. resistance to various fungi; Triamcinolone acetonide is an active ingredient of the corticosteroid group with anti-inflammatory, antipruritic and antiallergic activity; Gentamicin sulfate is a broad-spectrum antibiotic with high efficacy in the treatment of primary and secondary infections. The pharmacokinetics of Endix-G include the following: Gentamicin and other aminoglycoside antibiotics are generally poorly absorbed from the gastrointestinal tract but well absorbed when administered intramuscularly. Aminoglycoside antibiotics diffuse mainly into the extracellular fluid, but poorly into the cerebrospinal fluid, infected meninges, or into the eye. In addition, aminoglycosides are able to cross the placenta, but only small amounts are detected in breast milk. Systemic absorption of the antibiotic gentamicin has been reported when applied topically to exposed or burned skin, body cavities, or joints. The plasma half-life of gentamicin is 2 to 3 hours, which may be prolonged in neonates and in patients with renal impairment; Econazole for oral administration is metabolized in the liver to inactive compounds, and then excreted in the feces and urine. When used topically, the antifungal drug econazole can be absorbed through the epidermis, but systemic absorption is rare; Triamcinolone is well absorbed from the gastrointestinal tract and applied topically, especially when closed after applying the drug, applied on infected or damaged skin. Topical triamcinolone is metabolized in the skin to inactive active ingredients and excreted in the urine.

4. Dosage of Endix-G topical

In the correct cases, apply Endix-G to the diseased skin from 1 to several times per day. Dosage and usage mentioned in the article are for reference only. The specific dosage will depend on the specific location, condition and severity of the disease. Therefore, to get the right dose, patients need to consult a doctor or medical professional.

5. Endix-G side effects

When using Endix-G topical, patients may experience some unwanted effects (ADRs). Cases of transient mild irritation at the application site have been reported.
Most adverse effects of corticosteroids (such as the active ingredient triamcinolone found in Endix G) are related to inhibition of the hypothalamic-pituitary-adrenal axis, including hypertension, edema, and congestive heart failure. blood pressure, enlarged heart, hypokalemia, alkalosis...
When applying Endix-G to large areas, especially on damaged skin, may increase the risk of systemic side effects. Some common side effects (ADR >1/100):
Metabolic disorders including hypokalemia, increased sodium retention causing edema, increased blood pressure; Muscle atrophy, muscle weakness; Uncommon side effects (1/1000 Formation of blood clots; Psychiatric disorder accompanied by symptoms of emotional disturbance; Adrenal insufficiency, pseudo-Cushing; Lose weight with protein, children grow slowly; Decreased resistance; Increased risk of onset of underlying diseases such as tuberculosis, diabetes; Osteoporosis, skin atrophy, muscle atrophy, slow wound healing; Glaucoma, posterior subcapsular cataract (if prolonged use). Rare side effects (ADR <1/100): Increased intracranial pressure.
Some other ADRs:
Necrotizing vasculitis; Thrombophlebitis; Aggravation of the infection; Insomnia ; Faint; Defensive shock. Corticosteroid dose and duration are important factors in suppressing the pituitary-adrenal response to discontinuation stress. In addition, the location of the patient also plays an important role. Therefore, patients need to stop taking the drug gradually depending on the individual response.

6. Notes in the process of using Endix-G topical

Before using Endix-G, patients should carefully read the instructions for use and consult a doctor. Some contraindications to the use of Endix G include:
History of allergy to any ingredient of the drug; Skin infections caused by tuberculosis, syphilis or viruses (such as herpes viruses, vaccinia, varicella); Fungal skin infections of the ear in patients with perforated tympanic membrane; Bezet's ulcer disease, febrile disease. Some cautions when using Endix-G drug:
Limit treatment with continuous and prolonged corticosteroid therapy because of the risk of adrenal suppression, especially when applying pressure to the skin after applying the drug. Moreover, prolonged topical corticosteroid therapy can lead to a number of lesions such as skin atrophy, stretch marks, capillary dilation... The growth of bacteria strains is poor or no longer sensitive to antibiotics, including including drug-resistant fungal strains that can occur with topical antibiotic use. In case of itching, hypersensitivity or superinfection, Endix-G should be discontinued and appropriate treatment should be sought; Patients sensitive to propylene glycol should consult their physician before taking Endix G products; Women should not use Endix-G during pregnancy unless the possible risks are considered and accepted; Avoid direct contact with eyes; There are no data on the excretion of topical Econazole, Triamcinolone and Gentamicin into breast milk. However, caution should be exercised when Endix-G is applied to a nursing woman. Endix-g topical helps support the treatment or radical treatment of skin diseases, improving the quality of life of patients. However, this drug only promotes the best effect when used in the right dose, right object.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.