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Anti Ds DNA is an autoantibody with high value in the diagnosis of some autoimmune diseases such as lupus, systemic scleroderma... Currently, due to its high sensitivity, the anti Ds DNA test is often used. in the diagnosis of systemic lupus erythematosus.
1. What is Anti Ds DNA?
Anti Ds DNA is one of the autoantibodies that appear in people with autoimmune diseases, acting as anti-double-stranded antibodies to destroy the double-stranded DNA target antigens in the cell nucleus.
Autoantibodies are immune proteins produced by the body to damage its own tissues or parts by mistakenly targeting. Normally, immune cells can recognize and do not react to destroy the body's own antigens. However, autoantibodies do not distinguish between foreign antigens and self-antigens and lead to self-destruction of the body's own cells.
The causes of the appearance of autoantibodies are diverse and poorly understood. In many cases, the body's production of autoantibodies is due to genetic factors combined with an environmental trigger such as: viral infection or long-term exposure to certain toxic chemicals.
2. What is anti Ds DNA test?
The anti-Ds DNA test helps to quantify anti-double-stranded antibodies (Ds DNA) in the patient's blood.
Perform anti-Ds DNA test by methods and techniques such as:
Chemiluminescent immunoassay: Chemiluminescent immuno technology can help quantify the number of autoantibodies against double-stranded DNA in patient's blood. This method has high sensitivity and specificity, shorter test time. Immunofluorescence assay: In this test, antigen is attached to a fluorescent dye that fluoresces under ultraviolet light. If the patient's serum contains antibodies, an antigen-antibody reaction will occur and thereby detect whether or not anti-Ds DNA is present. Enzyme immunoassay ELISA: This test relies on the combination of antigens and antibodies in the patient sample to detect whether antibodies are present in the sample or not.
Xét nghiệm anti Ds DNA thường được sử dụng trong chẩn đoán bệnh lupus ban đỏ hệ thống
3. Purpose of anti Ds DNA test
Ds DNA autoantibody test is used for the purpose of diagnosing some autoimmune diseases when the patient has suspicious signs, including:
Systemic lupus erythematosus; Scleroderma; Dermatitis, polymyositis ; Mixed connective tissue disease; Sjogren's syndrome; CREST syndrome; Systemic vasculitis; Autoimmune arthritis. In addition, anti Ds DNA test is also performed to find the cause of some persistent signs such as: Constant joint pain, prolonged fever, fatigue, shortness of breath, blood in urine, muscle weakness , rash on the face... From there, help the doctor come up with a suitable treatment regimen.
4. Significance of anti Ds DNA test
Anti Ds DNA test is important for the diagnosis of systemic lupus erythematosus and for differentiating systemic lupus erythematosus from other autoimmune diseases. According to statistics, up to 80% of people with lupus erythematosus have a positive anti-Ds DNA test. In addition, this autoantibody can also be present in many other autoimmune diseases, when checked with the Anti Ds DNA test. During treatment, the Anti Ds DNA test helps to monitor the concentration of Anti Ds DNA in the patient's blood sample, to assess the risk of flare-up of kidney damage in people with lupus erythematosus with pre-existing kidney disease. there. It also helps to monitor disease activity and the effectiveness of treatments. In summary, the anti-Ds DNA test helps diagnose and monitor some autoimmune diseases, finding the cause for the prolonged abnormal signs. When performing the test, a number of factors can affect the results, so patients should have this test done at reputable medical facilities. Currently, the Laboratory - Vinmec International General Hospital is one of the leading prestigious addresses in the country, trusted by a large number of patients to examine in general and perform anti-Ds DNA test in particular. Thanks to the use of modern machines and equipment for testing and analysis, it has provided accurate information, helping doctors to assess the overall health of the person being tested, early detection. disease and suggest a timely treatment plan. In particular, with a space designed according to 5-star hotel standards, Vinmec guarantees to bring patients the most comfort, friendliness and peace of mind when visiting and receiving treatment at the hospital.
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