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Preforin is a drug whose main ingredient is a form of glucocorticoid, widely indicated in many diseases related to inflammation, allergies or diseases related to immune disorders. Below is some information about the uses of Preforin medicine.
1. Uses of the drug Preforin
Preforin 40mg drug has the main ingredient is Methylprednisolone (as Methylprednisolone sodium succinate) 40mg. Prepared lyophilized powder for injection.
Methylprednisolone is a glucocorticosteroid, which is a 6-alpha-methyl derivative of prednisolone. Methylprednisolone is a substance with anti-inflammatory, anti-allergic and immunosuppressive effects. Due to prednisolone methylation, the effects of salt-metabolizing corticosteroids have been excluded, so there is little risk of fluid retention and edema.
The anti-inflammatory effect of Methylprednisolone is increased by 20% compared to that of prednisolone. Methyprednosolon has not only important effects on inflammatory and immune processes but also on carbohydrate, protein and fat metabolism. These substances also act on the cardiovascular system, skeletal muscle and central nervous system.
Effects on inflammatory and immune processes: The anti-inflammatory, immunosuppressive and analgesic properties of glucocorticoids are used in most indications. Possible drug-induced effects include decreased number of immunoactive cells at the site of inflammation, decreased vasodilation, inhibition of phagocytosis, decreased production of inflammatory mediators of prostaglandins and cells associated with inflammation. mandarin. Effects on carbohydrate and protein metabolism: Glucocorticoids have a catabolic effect on proteins and amino acids are released into glucose and glycogen in the liver through gluconeogenesis. Glucose absorption by peripheral tissues may be reduced leading to hyperglycemia and hyperglycemia, especially in patients with diabetes or prediabetes. Effects on fat metabolism: Glucocorticoids have lipolytic effects, affecting mainly the extremities. It also has a lipogenic effect, which is evident in the chest, neck and head. These effects lead to a reallocation of fat storage sites in the body.
2. Indications and contraindications to the drug Preforin
Preforin drug is very widely indicated in many cases. Some indications of Preforin include:
Rheumatoid arthritis, systemic lupus erythematosus, some forms of vasculitis; Inflammation of the temporal and periarterial arteries, tendinitis; Sarcoid disease, bronchial asthma, chronic ulcerative colitis, hemolytic anemia, agranulocytosis. Severe allergic conditions including anaphylaxis or other allergies that do not respond to common antihistamines. In the treatment of cancer such as acute leukemia, lymphoma, breast cancer and prostate cancer. Methylprednisolone is also indicated in the treatment of primary nephrotic syndrome. Preforin 40mg is contraindicated in the following cases:
History of hypersensitivity to the main ingredient Methylprednisolone contained in the drug or any other excipients. Skin lesions caused by viruses, or fungi, caused by tuberculosis bacteria. In the process of using live vaccines Severe infections, except for patients with septic shock and tuberculous meningitis.
3. Dosage and how to take Preforin
Usage: Preforin is prepared in the form of lyophilized powder for injection. Mix powder with 1 to 3ml of distilled water and use intravenously or intramuscularly.
Dosage:
Local injection: Inject this solution at the injured site.
Patients with arthritis, rheumatism: Use the drug from 4 - 80mg, depending on the condition of the disease, treatment within 1 - 5 weeks. Tendonitis: Use injection of this drug from 4 -40 mg into the site under the tendon sheath Skin diseases: use an injection dose of 20 -60 mg IM injection (intramuscular):
For patients with increased hormone secretion Adrenal: 40mg/ 2 weeks injection In case of rheumatism: 40-120mg/week injection Patients with bronchial asthma, severe allergic rhinitis: 80-12mg/week injection dose Scleroderma during Recurrence time: use at a dose of 160mg / day and use for 1 week, then only use 64mg / day for 1 month. This is a reference dose, for each case the doctor has prescribed the most appropriate dosage. The drug is injected by medical personnel.
4. What are the side effects of Preforin?
Similar to other glucocorticoids, in addition to the superior therapeutic uses, side effects can also occur. The occurrence of side effects is largely dependent on the dose and duration of use of the drug. Some of the possible side effects include:
Common side effects: Abdominal pain above the navel, nosebleeds, hirsutism, increased blood sugar, joint pain, increased appetite, eating indigestion, trouble sleeping, diabetes, easily irritated by external factors, cataracts, glaucoma. Uncommon side effects: Vomiting and nausea, brain pseudotumor, skin atrophy, hyperpigmentation, acne, dizziness, headache, hallucinations, mood disturbances, unconsciousness, psychosis, increased blood pressure, edema, abdominal distension, gastric ulcer. Other possible side effects when taking Preforin include: Cushing's syndrome, which is common with prolonged use, infertility, hypokalemia, anaphylaxis, muscle weakness, and osteoporosis. It is necessary to inform your doctor if you experience side effects while taking the drug, so that you can take timely measures. Several measures are used to reduce the risk of side effects such as: Try to take the lowest effective dose and use it for the shortest time; administered every other day as once every 2 days in the morning to reduce hypothalamic-pituitary-adrenal axis suppression; if the dose is not high, it should be used once, there will be less side effects than divided doses and should be used in the morning; When using for a long time, the dose should be reduced gradually, should not be stopped suddenly, because the sudden use of the drug has the risk of causing acute adrenal insufficiency, which is very dangerous, so it is necessary to strictly adhere to the dose reduction as indicated. doctor.
5. Notes when using Preforin
Some things to keep in mind when using Preforin, include:
This is an injectable drug, so it should only be used under the direction and performed by a doctor or nurse. Side effects of this drug may be increased in patients such as those with hypothyroidism or cirrhosis of the liver. It is necessary to closely monitor or change the dose when taking the drug. It should be used with caution in patients with osteoporosis, those with recent vascular access, those with a history of psychiatric disorders, gastric ulcer and duodenal ulcer. Because taking this medicine can increase the severity of the above disease. Pregnancy and breast-feeding: For pregnant women using this drug can affect the fetus such as reducing the weight of the fetus, the use of the drug should be carefully considered. Breastfeeding women, although not contraindicated, should also consider carefully before using the drug. Avoid vaccination while on medication, especially live attenuated vaccines, as this puts you at risk for post-vaccination illness. Drug interactions may occur when used concomitantly with non-steroidal anti-inflammatory drugs, sympathomimetic drugs, antacids, etc. These drugs may increase the risk of side effects or reduce the main effect. by Preforin. This drug can increase blood sugar, so be careful with people with diabetes and if used, it may be necessary to adjust the dose of antidiabetic drugs. Here is some information about the uses and precautions when using the drug. You should use the drug exactly as prescribed by the doctor and absolutely do not arbitrarily use glucocorticoid drugs.
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