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Dipsope 5 contains the active ingredient Amlodipine besylate 5mg which is indicated in the treatment of essential hypertension. Let's learn about dosage, unwanted effects and notes when using Disope 5 through the article below.1. Uses of Dipsope 5
1.1. Indications to use Dipsope 5 "What is Disope 5?". Disope 5 drug containing the active ingredient Amlodipine besylate 5 mg is indicated in the following cases:
Treatment of essential hypertension, hypertension in patients with metabolic complications such as diabetes mellitus; Prophylactic treatment in patients with stable angina pectoris. 1.2. Pharmacodynamics of Dipsope 5 Active ingredient Amlodipine belongs to Dihydropyridine derivatives. Mechanism of action is through blocking calcium channels across cell membranes, blocking voltage-dependent L-type calcium channels, acting on blood vessels in the muscle and heart.
The antihypertensive effect of the drug is through peripheral arterial smooth muscle relaxation, with little effect on myocardial calcium channels. Therefore, Amlodipine does not impair atrioventricular conduction in the heart, does not affect the force of contraction. The drug also works to reduce vascular resistance in the kidneys, thereby helping to increase renal blood flow and improve kidney function.
Amlodipine does not adversely affect plasma lipid levels or glucose metabolism, so it can be used in the treatment of hypertension in patients with diabetes. However, there is still not enough evidence to prove that Amlodipne is effective in reducing mortality.
Amlodipine can be used concurrently with thiazide diuretics, beta-channel blockers and angiotensin-converting enzyme inhibitors in the treatment of hypertension. The drug also works in both standing, lying and sitting positions.
Amlodipine has a slow effect, so it is less likely to cause acute hypotension or reflex increase in heart rate. The antianginal effect of Amlodipine is through the mechanism of dilating the peripheral arterioles, thereby reducing the total resistance in the peripheral blood vessels. The action of the drug does not reduce heart rate, but reduces the workload of the heart, reducing the need for energy and oxygen supply to the heart muscle. This helps reduce the risk of angina.
In addition, amlodipine exerts a dilating effect on coronary arteries both in areas of normal blood supply and in ischemic areas. This effect increases oxygen demand in patients with angina. The duration of the antianginal effect of Amlodipine is approximately 24 hours.
1.3. Pharmacokinetics Amlodipine 5mg has an oral bioavailability of approximately 60-80% and is unaffected by food. Peak plasma concentrations are reached 6-12 hours after oral administration. The half-life of Amlodipine ranges from 30 to 40 hours. Peak plasma concentrations of Amlodipine are achieved 7-8 days after dosing.
The volume of distribution of Amlodipine is about 21 liters/kg body weight, about 98% of the dose is protein bound. The plasma clearance is 7 ml/min/kg body weight because the drug is excreted mainly through metabolism in the liver.
Amlodipine metabolites are inactive and are excreted in the urine.
In patients with impaired liver function, the half-life of amlodipine is increased. Therefore, in some cases it is necessary to reduce the dose or prolong the time between doses.
2. Dosage of Disope 5
Disope 5 antihypertensive drug belongs to the group of prescription drugs, so patients need to take the dose prescribed by the doctor. Some notes on drug dosage are as follows:
The dose of medicine to treat angina, hypertension is indicated in accordance with each patient. Usually, the general starting dose is 5mg/time/day. The dose can then be adjusted according to the patient's tolerability; In case the drug Disope 5 has no effect after 4 weeks of treatment, the dose should be increased; In case of co-administration with thiazide diuretics, no dose adjustment of Disope 5 is required.
3. Disope 5 . drug side effects
“What diseases does Disope 5 treat and can it cause any unwanted effects?”. Accordingly, the drug Disope 5 may cause some of the following undesirable effects:
Swelling of the feet, hands, ankles or legs; Stomach pain, headache, dizziness, abdominal pain, drowsiness, excessive fatigue; Frequent chest pain or fast heartbeat, heavy heart, irregular heartbeat, fainting. In case of experiencing unwanted effects, the patient should stop using Disope 5 and notify the treating doctor for timely treatment.
4. Notes when using Disope 5
Contraindicated to use Disope 5 in the following cases:
Patients with heart failure who have not been treated stably; Patients with hypersensitivity to Dihydropyridine or any ingredient of Disope 5mg. Precautions for use:
Be careful when using Disope 5 in patients with aortic stenosis, patients with impaired liver function, patients with heart failure after myocardial infarction. Pregnant women: Disope 5 in particular and calcium channel blockers in general can inhibit premature uterine contractions. However, the drug did not cause adverse effects on the process of childbirth. Physicians should take into account the risk of fetal hypoxia in the event of maternal hypotension during antihypertensive drug therapy. This is a common risk with antihypertensive drug therapy. Therefore, to ensure safety, do not use Disope 5 in pregnant women. Lactation: There are no studies evaluating the accumulation in breast milk of Amlodipine.
5. Drug interactions
Disope 5 may cause some drug interactions as follows:
Amlodipine's blood pressure lowering effect is increased when used with anesthetics; Lithium can cause nausea, vomiting, neurotoxicity, diarrhea when used concurrently with Disope 5; Nonsteroidal anti-inflammatory drugs (NSAIDs), especially Indomethacin may reduce the effect of Amlodipine; Drugs that are strongly bound to plasma proteins such as Hydantoin, a coumarin derivative may increase the free plasma concentration of Amlodipine. Therefore, caution should be exercised when using these drugs in combination. In summary, Dipsope 5 is indicated in the treatment of essential hypertension. Using the drug as prescribed by your doctor will help you maximize the effectiveness of the treatment and limit the side effects of the drug.
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