This is an automatically translated article.
Zanedip medicine 10mg containing the active ingredient Lercanidipine is indicated in the treatment of hypertension. Zanedip can be used alone or in combination with other antihypertensive agents. Continue reading the following article for more information about the drug Zanedip 10mg.
1. What is Zanedip 10mg?
Zanedip 10mg medicine has the main ingredient is Lercanidipine. This is an antihypertensive drug alone or in combination with diuretics, beta-blockers, ACE inhibitors. Lercanidipine belongs to the dihydropyridine group, which is a calcium antagonist and inhibits the transmembrane calcium influx into cardiac and smooth muscle. The mechanism of antihypertensive action of the drug Zanedip is to directly relax the vascular smooth muscle, reducing the total peripheral resistance.
Although Zanedip has a short plasma half-life, it has a prolonged antihypertensive effect due to a higher amount of drug distribution in the vascular wall than in the vascular lumen. Due to its high vascular selectivity, Zanedip has no adverse effect on myocardial contractility.
Because the vasodilator effect of Zanedip is gradual in onset, acute hypotension with reflex tachycardia has rarely been reported in hypertensive patients.
2. Indications and contraindications of the drug Zanedip 10mg
Zanedip 10mg is indicated in the following cases:
Treatment of idiopathic mild to moderate hypertension. The drug Zanedip 10mg is contraindicated in the following cases:
Hypersensitivity to Lercanidipine, the Dihydropyridines or to any component of the drug; Women who are pregnant or breastfeeding; Women of childbearing potential, unless effective birth control methods are used; People with flow obstruction in the left ventricle; Untreated congestive heart failure; Unstable angina ; Had a myocardial infarction within 1 month; In combination with a strong inhibitor of CYP3A4, cyclosporin.
Thuốc Zanedip 10mg được chỉ định trong điều trị tăng huyết áp
3. Dosage and how to use Zanedip
Zanedip is to be taken orally, at least 15 minutes before meals.
The recommended dose of Zanedip is 10 mg once daily, the dose may be increased to 20 mg, depending on the patient's response. The determination of the dose of Zanedip should be gradual, as the antihypertensive effect can reach its maximum effect after 2 weeks of use. For some people who cannot be controlled with single antihypertensive drugs, Zanedip can be combined with a β-adrenoceptor blocker (Atenolol) or a diuretic (Hydrochlorothiazide) or an angiotensin converting enzyme inhibitor.
Although pharmacokinetic data and clinical experience suggest that no adjustment of the daily dose of Zanedip is necessary, particular caution should be exercised when initiating therapy in the elderly.
As with other dihydropyridines, an overdose of Zanedip may cause strong peripheral vasodilation with marked hypotension and reflex tachycardia. In case of severe hypotension, bradycardia and loss of consciousness, the patient needs cardiovascular support with intravenous atropin. Because of the long-lasting pharmacological effects of Lercanidipine, patients with overdose should have their cardiovascular status monitored for at least 24 hours.
If you forget to take a dose of Zanedip, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take twice the prescribed dose.
4. Side effects of the drug Zanedip
When using Zanedip 10mg, you may experience side effects of the drug.
Uncommon side effects of Zanedip include:
Headache, dizziness; Tachycardia, palpitations ; Flushing; Peripheral obesity. Rare side effects of Zanedip include:
Angina pectoris ; Sleepy; Nausea, vomiting, indigestion, diarrhea, abdominal pain; Rash; Muscle pain; Polyuria; Weakness, fatigue. Very rare side effects of Zanedip include:
Syncope; Increased sensitivity; Peripheral edema. Inform your doctor about the side effects you experience while using Zanedip.
Khi sử dụng thuốc Zanedip 10mg, bạn có thể gặp một số tác dụng phụ
5. Zanedip drug interactions
Zanedip may interact with certain foods and medications. Therefore, Zanedip should not be used together with:
CYP3A4 inhibitors such as Itraconazole, Ketoconazole, Ritonavir, Erythromycin, Troleandomycin. The combination of Zanedip with Cyclosporin is not recommended. Zanedip should not be taken with grapefruit juice. In summary, Zanedip is indicated in the treatment of hypertension. All information above is for reference only. The use of the drug should be under the guidance of a specialist to ensure safety.
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