This is an automatically translated article.
Serotonin syndrome often occurs, can affect the patient's life, but can also be prevented if attention is paid to the side effects of drugs that can cause this syndrome. The management of Serotonin syndrome usually depends on the extent of the disease.
1. What is Serotonin Syndrome?
Serotonin is a chemical produced by the body, Serotonin allows brain cells as well as other cells of the nervous system to exchange information with each other. If there is less serotonin in the brain, it can be a factor in depression. In cases where too much Serotonin can cause excessive nerve cell activity and lead to potentially fatal symptoms, this is known as Serotonin syndrome.The main cause of Serotonin syndrome is an overdose of drugs or a combination of drugs at the same time (eg, antidepressant combined with Triptan group...) will cause an increase in Serotonin levels. in the body.
Nguyên nhân chính dẫn đến hội chứng Serotonin là sử dụng thuốc quá liều
2. Signs of Serotonin Syndrome
When you have Serotonin syndrome, you will feel agitated or restless, confused or have a headache. In addition, other signs of Serotonin syndrome may include: Dilated pupils, nausea, and vomiting Changes in blood pressure or temperature, rapid heart rate, heavy sweating Diarrhea, shaking, floating goosebumps Muscle loss of coordination, muscle convulsions In some severe cases, Serotonin syndrome can be life-threatening, so if you experience the following dangerous signs of Serotonin syndrome, you should seek immediate medical attention. Get immediate help:
High fever, convulsions Heart arrhythmia Unconscious
3. Serotonin syndrome management
The management of Serotonin syndrome depends on the extent of the disease. Specifically as follows:
If the disease has mild symptoms, just stop the drugs that cause Serotonin syndrome, and monitor the condition of the disease. After 24 hours the symptoms subsided. In case of gastrointestinal poisoning before 6 hours, gastric lavage, activated charcoal should be given to remove drugs that are the cause of Serotonin syndrome. If respiratory failure is severe, it is necessary to combine antipyretic treatment, adequate fluid resuscitation, sedative drugs to slow the heart rate, lower blood pressure, oxygen ...
Việc xử trí hội chứng Serotonin phụ thuộc vào tình trạng của người bệnh
Medications for Serotonin Syndrome include:
Benzodiazepines, a class of drugs used to treat Serotonin syndrome to help control agitation, seizures, or muscle stiffness. Cyproheptadin (Periactin) to block extra Serotonin production. When the patient is dehydrated and feverish, intravenous fluids and electrolytes should be infused. Medicines to control heart rate and blood pressure such as: Esmolol (Brevibloc) or Nitroprusside (Nitropress) if your heart rate is fast and blood pressure is high; Phenylephrine or Epinephrine when the patient has a slow heart rate and very low blood pressure. Serotonin syndrome is common and can be life-threatening, but it can be prevented if you pay attention to the side effects of medications that can cause this syndrome. Prevention methods include:
Avoid self-administering or increasing the dose of drugs that affect Serotonin levels in the body. When combined with a newly prescribed drug and that drug has a risk of causing Serotonin syndrome, the patient must consult a doctor for appropriate indications. In case of mild Serotonin syndrome, the patient needs to stop using the drug and then go to a medical facility to have an appropriate treatment.
Người bệnh cần chú ý đến những tác dụng phụ của các loại thuốc có thể gây ra hội chứng này
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