Ecotrin: Uses, indications and notes when using

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Ecotrin drug, generically known as Aspirin, is a non-steroidal anti-inflammatory drug. It is used to reduce fever and relieve mild to moderate pain caused by conditions such as muscle aches, toothaches, the common cold, and headaches. It is also used to reduce pain and swelling in inflammatory arthritis conditions.

1. Ecotrin

What is Ecotrin? Ecotrin (Aspirin) is also known as a salicylate, antipyretic, non-steroidal anti-inflammatory drug, platelet aggregation inhibitor.
The drug comes in the form of orange, round, enteric-coated tablets, printed with the word "ECOTRIN LOW". The content in one tablet is 81mg.
Pharmacokinetics
Oral bioavailability (%): 68 ± 3. Distribution: Binding to plasma proteins is 49%. Hyperuremia reduces the ability of Ecotrin to bind to plasma proteins. Clearance (ml/min/kg): 9.3 ±1.1. Clearance changes in the elderly, cirrhosis will be longer. Volume of distribution (litre/kg): 0.15 ± 0.03. The half-life of Ecotrin is 0.25 ± 0.03. Altered half-life in hepatitis. Excreted mainly by the kidneys excreted in the urine as free salicylic acid and conjugated metabolites.

2. How to use the drug

The drug is taken orally. Do not lie down right after you take this medicine (at least 10 minutes). If abdominal pain occurs while you are taking this medicine, you may take it with food or milk. Swallow the soluble tablet whole, do not crush or chew the enteric coated tablet. Doing so may increase abdominal pain. Pain relievers work best if they are used when the first signs of pain appear. If you wait until the pain becomes persistent, the medicine may not work. You should not take this medicine to self-treat pain for longer than 10 days. You should not use this medicine to self-treat a fever that lasts more than 3 days.

Dosage and administration
Adults
Pain relief/fever reducer: Dose of 325 - 650mg, every 4 hours is necessary while still having symptoms. Anti-inflammatory (rheumatoid arthritis): Dosage 3-5g/day, divided into several small doses. Patients with inhibition of platelet aggregation: Dosage 100 - 150 mg/day. Children
Pain relief, hypothermia: Dosage is 50 - 75 mg/kg/day, divided into 4-6 times, ensuring not to exceed the total dose of 3.6g/day. Anti-arthritis, rheumatoid arthritis: The dose is 80-100 mg/kg/day, divided into several small doses (5-6 times), up to 130 mg/kg/day when the disease does not progress.

3. Indications, contraindications

Indications In case of relief of mild and moderate pain, while reducing fever. In acute and chronic inflammation such as rheumatoid arthritis, inflammatory (degenerative) osteoarthritis and rheumatoid spondylitis. Use in the secondary prevention of myocardial infarction and stroke in patients with a pre-existing medical history. Treatment of Kawasaki syndrome. Contraindications People who have had symptoms of asthma, asthma, rhinitis or urticaria. People with hemophilia, thrombocytopenia, gastric or duodenal ulcer, liver failure, renal failure, especially those with glomerular filtration rate less than 30 ml/min and cirrhosis.

4. Side effects

Digestion: Abdominal discomfort, heartburn, nausea, vomiting. Ears: Difficulty hearing, tinnitus. Kidneys: Dark urine, change in urine output. Skin: Jaundice, easy bruising This medicine can rarely cause serious bleeding from the stomach or intestines or other areas of the body. If you notice any of the following serious side effects tell your doctor right away: black stools, head in the abdomen, vomiting that looks like coffee grounds, difficulty speaking, weakness on one side of the body body, sudden vision changes or severe headache.

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Reference source: webmd.com