What are the uses of Medrol 16mg?

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1. What is Medrol 16mg?

The composition of the drug Medrol 16mg is methylprednisolone 16mg and the system of excipients: Lactose, cornstarch, sucrose, calcium stearate, liquid paraffin...
Methylprednisolone is a steroid with better anti-inflammatory effects than prednisolone, tends to tend to cause less sodium and water retention while the relative potency of methylprednisolone is about 4 times that of hydrocortisone.

2. Uses of medrol 16mg

Uses of medrol 16mg indicated include:
2.1. Indications for endocrine disorders The use of medrol 16mg for primary/secondary adrenocortical insufficiency; Congenital adrenal hyperplasia; Non-purulent thyroiditis; High blood calcium associated with cancer. 2.2. Indications in non-endocrine disorders Rheumatic disorders: the drug is used as adjunctive therapy with short-term indications (to help patients get through the acute or exacerbation phase) in diseases such as: : Psoriatic arthritis ; Rheumatoid arthritis ; Ankylosing spondylitis ; Acute/subacute bursitis; Efficacy of medrol 16mg for acute nonspecific tendon bursitis; Acute gouty arthritis; Post-traumatic osteoarthritis; Synovitis ; Inflammation of the condyle of the bone. Colloidal system disease: The drug is used in the exacerbation phase or as maintenance treatment in the following cases: Systemic lupus erythematosus; Systemic dermatomyositis; Acute rheumatic heart disease; Rheumatoid muscle pain; Uses of medrol 16mg for giant cell arteritis. Skin diseases: Exfoliative dermatitis; Fungal warts; Severe psoriasis; Severe seborrheic dermatitis; Pemphigus; Herpes bullous dermatitis; Severe erythema multiforme. Allergic diseases: medicines to help control severe or difficult allergic conditions that have failed conventional treatments: Hypersensitivity reactions to the drug; Contact dermatitis ; Hereditary atopic dermatitis; Allergic rhinitis ; Serum disease; Asthma. Eye disease: severe acute and chronic allergic conjunctivitis of the eye and its appendages such as: Allergic conjunctivitis; Allergic conjunctivitis ; Corneal infection caused by Herpes Zoster; Keratitis; Anterior inflammation; Inflammation of the choroid - retina; Small choroiditis, choroiditis; Optic neuritis; Sympathetic eye inflammation; Iritis, iridocyclitis. Respiratory tract disease Symptomatic sarcoidosis; Loeffler's syndrome; beryllium intoxication; Fulminant or disseminated pulmonary tuberculosis concurrently with anti-tuberculosis chemotherapy; Aspiration pneumonia. Hematologic disorders Hemorrhagic thrombocytopenia in adults of unknown etiology; Secondary thrombocytopenia in adults; Acquired hemolytic anemia; Thrombocytopenia; Congenital hypoplastic anemia. Cancers: Drugs used for temporary treatment of diseases: Leukemia, adult lymphoma; Acute leukemia in children. Edema: Diuretic and protein-lowering drugs in nephrotic syndrome without high blood urea or nephrotic syndrome due to lupus erythematosus. Gastrointestinal diseases: helping patients to survive the critical illness of the disease: Ulcerative colitis; Inflammation of the small intestine. Nervous system: Multiple sclerosis; Suitable for brain tumor. Organ transplant. Other indications: Tuberculous meningitis with subarachnoid occlusion or threat of occlusion; Worm disease.

3. Dosage of medrol 16mg

The starting dose of methylprednisolone may vary from 4-48mg/day, depending on the disease to be treated. If the disease is less severe, a low dose may suffice, but in some patients a higher starting dose may be required. Diseases requiring high doses of methylprednisolone include:
Multiple sclerosis (200mg/day); Cerebral edema (200-1000mg/day); Organ transplantation (7mg/kg/day). If there is no clinical response after a period of use of methylprednisolone, the drug should be discontinued and a more appropriate therapy switched to. If long-term treatment wants to stop methylprednisolone, it must be stopped gradually, not suddenly. After a satisfactory response has been observed, the maintenance dose of methylprednisolone should be determined by reducing the initial dose in small increments, establishing an appropriate interval while achieving sustained clinical response.
Situations requiring dose adjustment of methylprednisolone: ​​
When there is a change in clinical status secondary to remission or after exacerbations of the disease; Individual patient response to methylprednisolone; Effects of stress states unrelated to treatment (this situation may require increasing the dose of methylprednisolone over time). In addition, methylprednisolone can be used alternately: a regimen of twice the daily dose of corticosteroids, used in the morning on alternate days, to promote beneficial effects of corticosteroids and minimize adverse effects. desired, blocking the pituitary-adrenal axis, Cushing's pseudostate, corticosteroid withdrawal symptoms, inhibiting the growth of children...

4. Contraindications of Medrol 16mg

Patients with systemic fungal infections; Hypersensitivity to methylprednisolone; Use live or live attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids.

5. Side effects of medrol 16mg

Infections, opportunistic infections; Immune system disorders: hypersensitivity to drugs such as anaphylaxis, decreased reaction to skin tests; Endocrine disorders: Cushing, hypothyroidism, sudden steroid withdrawal syndrome...; Metabolism and nutrition disorders: fluid retention, glucose imbalance, increased appetite, increased insulin requirements, metabolic acidosis, sodium retention; Psychiatric Disorders: Abnormal behavior, emotional disturbance, anxiety, confusional state, insomnia, irritability, psychosis, mood/character changes, neurotic behavior, confusion psychosis; Nervous system disorders: amnesia, cognitive disturbances, convulsions, headache, increased intracranial pressure, epidural fat deposition; Eye disorders: cataracts, bulging eyes, glaucoma, central serous chorioretinopathy; Ear and Inner Ear Disorders: Dizziness; Congestive heart failure; Vascular disorders: high blood pressure, low blood pressure; Respiratory, thoracic, mediastinal disorders. Digestive disorders: abdominal distension, abdominal pain, diarrhea, gastric bleeding, intestinal perforation, nausea, esophageal ulceration, pancreatitis, gastrointestinal ulceration, gastrointestinal bleeding...; Skin and subcutaneous tissue disorders: angioedema, ecchymosis, erythema, hirsutism, pruritus, skin atrophy, striae, urticaria...; Musculoskeletal and connective tissue disorders: arthralgia, growth retardation, muscle atrophy, muscle weakness, myalgia, neurogenic arthropathy, sclerosis, osteoporosis, pathological fracture; Irregular menstruation; Fatigue, slow wound healing; Increased alanine aminotransferase, increased aspartate aminotransferase, increased blood alkaline phosphatase, decreased blood potassium, decreased carbohydrate balance, increased intraocular pressure, increased urinary calcium... Achilles tendon rupture.

6. Medrol 16mg for pregnant and lactating women

There is no evidence that corticosteroids (medrol 16mg) have an effect on fertility.
For pregnant women: Some animal studies have shown that corticosteroids when administered to the mother in high doses can be teratogenic, however corticosteroids do not appear to cause birth defects when used in women. pregnant. Because there is not enough evidence of safety for pregnant women, so Medrol 16mg should be used during pregnancy only when clearly needed.
Some corticosteroids can cross the placenta and there is an increased incidence of low birth weight in mothers receiving corticosteroids, so infants born to mothers who have received significant doses of corticosteroids should be carefully monitored for these conditions. signs of adrenal insufficiency.
Corticosteroids excreted in breast milk may inhibit growth and interfere with endogenous glucocorticoid production in nursing infants. Therefore, Medrol 16mg should only be used by nursing women if the benefit to the mother outweighs the risk to the baby.
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