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Glibenclamide 5mg is a medicine used by people with diabetes to lower blood sugar levels to normal. Glibenclamide is taken in the morning or with the first main meal. However, depending on the blood glucose concentration of each patient, there is an appropriate dose of the drug.1. Uses of the drug Glibenclamide
Glibenclamide bp 5mg is a drug with the active ingredient is Glibenclamide with the strength of 5mg. In addition, in the composition of the drug, there are excipients including: anhydrous lactose, microcrystalline cellulose PH102, magnesium stearate.
Glibenclamid drug is prepared in the form of long white tablets, on both sides of the tablets are engraved with lines, edges and healthy members. The drug is packaged in a box of 10 blisters x 10 tablets or a box of 5 blisters x 20 tablets.
Glibenclamide is effective in lowering blood sugar in non-insulin dependent diabetic patients for whom diet alone has not been effective.
Glibenclamid 5mg is contraindicated in the following cases:
Patients with hypersensitivity to the drug Glibenclamid or any ingredient in the drug. Patients with a history of hypersensitivity to sulfonylureas or related drugs. Patients with type 1 diabetes or juvenile or unstable diabetes. The patient was comatose due to complications of diabetes. Patients with impaired liver function, severe kidney function, malnutrition. The drug glibenclamide should not be used by pregnant and lactating women. Patients present with acute symptoms of metabolic decompensation in infection or gangrene.
2. How to use and dose Glibenclamide bp 5mg
Glibenclamide is used orally. Patients should take a single dose at breakfast or the first main meal. During treatment, patients need to coordinate with diet and physical activity, exercise and sports.
The dose of Glibenclamide depends on the patient's blood glucose level. Before each course of treatment, it is necessary to check the blood sugar level of each patient.
Dosage for adults:
Initial dose: 2.5 - 5mg per day, take the drug 30 minutes before meals. If necessary, the dose should be adjusted, every 1 - 2 weeks, increasing by 2.5 mg / time until blood sugar levels reach normal values. Maintenance dose: patients take 2.5 - 10mg/day. For doses higher than 10mg/day, it should be divided into 2 doses. The maximum dose that the patient can use is 15mg/day. Dosage for patients switching from another antidiabetic drug:
Starting dose: 2.5 - 5mg immediately after stopping the previous drug. In case of need to increase the dose, increase each time by 2.5mg until the required glucose concentration is achieved. Dosage in children: Glibenclamide is not recommended for use in children.
For the elderly: It is necessary to avoid taking the drug or reduce the dose.
For people with liver damage, kidney damage: Use the drug at a lower dose than the usual dose, patients take a dose of 1.25mg/day.
3. In case of overdose, forget the dose of Glibenclamide and how to handle it
Symptoms and manifestations when using Glibenclamide 5mg overdose:
When taking an overdose of Glibenclamide or due to interactions with some other drugs during use, patients may have hypoglycaemic reactions. Manifestations are hypoglycemia causing headache, excessive sweating, insomnia, behavioral disturbances, irritability and poor alertness. In more severe cases, it can cause loss of consciousness, convulsions, even coma and death. In this case, it is necessary to supplement the amount of sugar by eating sugar to overcome hypoglycemic episodes, and at the same time, notify the doctor immediately. The patient can eat more sugar after 15 minutes if needed. In case the patient is in a coma, a saccharose solution can be pumped into the stomach or intravenous glucose infusion.
In case the patient forgets a dose of Glibenclamide bp 5mg, it should be taken as soon as he remembers. If it is almost time for your next dose, skip the missed dose and take your next dose as scheduled. Do not take twice the prescribed dose of Glibenclamide.
4. Glibenclamide 5mg side effects
Common side effects: The most common are nausea, vomiting, diarrhea and constipation.
Uncommon side effects:
Affects endocrine causing hypoglycemia. Skin effects: The drug causes skin rash, urticaria. Rare side effects:
Use of drugs that reduce white blood cells, thrombocytopenia and red blood cells. Effects on circulation: Causes allergic vasculitis. Jaundice may be caused by hepatitis or by cholestasis. Some patients may be sensitive to light, with temporary visual impairment.
5. What should patients pay attention to when using Glibenclamid 5mg?
Caution should be exercised when using Glibenclamide for patients with impaired renal function, those who are undernourished or those with cerebral arteriosclerosis and the elderly. Patients who have had an allergic reaction to sulfonamides and sulfonamide derivatives may be cross-allergic to glibenclamide. Glibenclamide can cross the placenta and cause hypoglycemia in the fetus. Therefore, it is necessary to replace glibenclamide with insulin in pregnant women. Glibenclamide is not recommended for use by women who are breastfeeding. When used together with other drugs such as sulfonamides, non-steroidal anti-inflammatory drugs, beta-blockers, cimetidine, chloramphenicol,... may increase the hypoglycemic effect. The hypoglycemic effect of glibenclamide may be reduced when used concurrently with thiazide diuretics, estrogen-containing oral contraceptives, sympathomimetics, calcium channel blockers, isoniazid, etc. The use of glibenclamide in combination with salbutamol or terbutaline may increase blood glucose. Co-administration of glibenclamide with anti-tuberculosis drugs may interfere with the hypoglycemic effect of the drug. Glibenclamide 5mg is effective in lowering blood sugar in diabetic patients unresponsive to dietary changes alone. Patients need to follow the doctor's prescription in combination with maintaining a scientific diet and exercising to ensure blood glucose levels. At the same time, regularly check blood sugar levels to adjust the dose of medicine in accordance with your health status.
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