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Cefoperazone Sulbactam is known to be a bactericidal antibiotic that inhibits bacterial cell wall synthesis by combining with one or more penicillin binding proteins. Let's find out the detailed information about this drug, you will know how to use it properly.
1. What is Cefoperazone Sulbactam?
Cefoperazone Sulbactam is a drug containing two main ingredients: Cefoperazone (as Cefoperazone sodium) 0.5g and Sulbactam (as Sulbactam sodium) 0.5g.
With the ingredient Cefoperazone, this is a 3rd generation cephalosporin semi-synthetic antibiotic, known for its effective bactericidal ability by inhibiting the synthesis of the growing and dividing bacterial cell wall. Cefoperazone is a very stable antibiotic against beta-lactamases formed in most gram-negative bacteria. Therefore, this ingredient has strong activity on a broad spectrum of gram-negative bacteria, from penicillinase-producing strains of N. gonorrhoeae and to strains such as Enterobacter, Citrobacter, Proteus, Morganella, Providencia, Salmonella, Shigella and Serratia spp. ). In particular, this active ingredient is extremely effective against bacteria resistant to other beta-lactam antibiotics.
With the ingredient Sulbactam, this is a substance similar in structure to beta lactam but has weak antibacterial activity, so it is rarely indicated for clinical use alone. Because Sulbactam has the ability to inactivate beta lactamase enzymes, it will contribute to the protection of beta lactam antibiotics against degradation. From here, Sulbactam is often used in combination with the penicillin group to expand the spectrum of action of penicillin against bacteria including enteric bacteria, E. coli, staphylococcus, anaerobic bacteria Bacteroides, Acinetobacter or Branhamella, Klebsiella, Neisseria, Proteus...
2. Indications and contraindications of Cefoperazone Sulbactam
2.1. Indications Cefoperazone Sulbactam is formulated as an injection, indicated for the treatment of infections caused by specific susceptible bacteria:
Patients with existing upper and lower respiratory tract infections. The patient has an upper and lower urinary tract infection. People with diseases such as peritonitis, cholecystitis, cholangitis and some other abdominal infections. Patients with infections of blood, skin, soft tissues, bones, joints, pelvis, meningitis. People with endometrial infections, gonorrhea and other sexually transmitted diseases. 2.2. Contraindications Cefoperazone Sulbactam is contraindicated in patients with a history of allergy to penicillins, sulbactam, cefoperazone or other cephalosporin antibiotics.
3. Dosage and how to use Cefoperazone Sulbactam
Cefoperazone Sulbactam is prepared in the form of intramuscular injection or intravenous infusion with the following reference doses:
Adults: Patients with mild and moderate infections use the drug at a dose of 1-2g (Cefoperazone) every 12 hours . Patients with severe infections use the drug at a dose of 2-4g every 12 hours. Children: Use the drug at a dose of 25-100mg/kg every 12 hours. Note, patients with kidney disease do not need to reduce the dose, however, the dose for people with liver disease or biliary obstruction should not exceed 4g/24 hours.
4. Side effects of Cefoperazone Sulbactam
According to medical experts, Cefoperazone Sulbactam is well tolerated, so most of the side effects are mild and moderate. Some common side effects during taking the drug include:
Appears a feeling of nausea, vomiting or diarrhea. Skin allergy with manifestations of erythema, urticaria. Long-term use of the drug can cause reversible leukopenia, positive Coomb's reaction, erythrocytosis, transient decrease in eosinophils, platelets. In some cases, hypoprothrombinemia was noted.
5. Drug interactions Cefoperazone Sulbactam
Cefoperazone Sulbactam has the potential to interact with some of the following drugs:
Concomitant use of aminoglycoside antibiotics will reduce the drug's activity. If needed, you should pay attention to interrupt the infusion and wash the infusion tube between two doses. Be careful when combining with anticoagulants, thrombolytic drugs, some non-steroidal anti-inflammatory drugs, because they will increase the risk of bleeding. Do not take with drugs containing ingredients such as amikacin, gentamicin, kanamycin B, doxycycline, meclofenoxate, ajmalin, diphenhydramine, potassium magnesium aspartate.
6. Be careful when using Cefoperazone Sulbactam
Cefoperazone Sulbactam should be used with caution in patients allergic to penicillin. Cefoperazone Sulbactam can be combined with other antibiotics to treat some dangerous diseases. However, if used in combination with aminoglycoside antibiotics, the patient should be monitored for renal function during treatment. Cefoperazone Sulbactam should only be used in pregnant women and nursing mothers when absolutely necessary. Using Cefoperazone Sulbactam at the right dose, avoiding overdose may cause increased neuromuscular excitability, convulsions, especially in people with renal failure. In this case, hemodialysis can remove cefoperazone and sulbactam from the body. Above is some information to help you learn about Cefoperazone Sulbactam. To avoid antibiotic resistance, you should use the drug according to the instructions and instructions of the doctor and medical professionals, absolutely do not arbitrarily use and stop taking the drug will potentially cause many harms to your health. health.
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