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Koact drug is a drug belonging to the group of antibiotics against infections with a broad spectrum of action. The drug is used on many different types of infections. Let's learn about the use of Koact pills through the article below.
1. Uses of Koact 625
What is Koact 1000 drug? Koact 625 is an antibiotic with a combination of two main active ingredients: Amoxicillin (as Amoxicillin trihydrate) 500mg and Clavulanic Acid (as Potassium clavulanate) 62.5mg. In addition, Koact medicine also has a strength of 1000mg, which is Koact 1000 with the ingredients Amoxicillin 875mg and clavulanic acid 125mg.
Amoxicillin is a semi-synthetic beta-lactam antibiotic with a broad spectrum of activity against many Gram-positive and Gram-negative bacteria, the mechanism of action is inhibition of bacterial cell wall synthesis. However, the antibiotic Amoxicillin is easily degraded by beta lactamase enzymes secreted by gram-negative bacteria and staphylococcus (Staphylococcus aureus), causing hydrolysis of the beta-lactam ring in the structure of Amoxicillin. Therefore, this antibiotic is limited to the strains of bacteria that produce this yeast.
Clavulanic acid has a higher affinity than Amoxicillin for beta lactamases secreted by bacteria, so it binds to this enzyme and prevents these enzymes from destroying the ring of beta lactam antibiotics. It has a high affinity for beta-lactamase enzymes because clavulanic acid is structurally similar to penicillins and cephalosporins. Therefore, clavulanic acid has the ability to inhibit beta-lactamase enzymes secreted by most Gram-negative bacteria and Staphylococcus aureus.
When these two substances are combined together, clavulanic acid helps the antibiotic Amoxicillin not be broken down by lactamase enzymes, thereby expanding the antibacterial spectrum of Amoxicillin. When co-administered with clavulanic acid there is no change in the action or mechanism of action of Amoxicillin.
The effect of the drug Koact 1000 and Koact 625 is against many types of bacteria such as gram-negative and gram-positive bacteria, including Staphylococcus aureus.
2. Indications and contraindications for using Koact
Koact 625 medicine is used in the following cases:
Upper respiratory tract infections such as: nasopharyngitis, rhinosinusitis, otitis media, tonsillitis. Lower respiratory tract infections caused by susceptible bacteria or beta-lactamase-producing bacteria: Exacerbation of chronic bronchitis, lobar pneumonia, bronchopneumonia. Genitourinary tract infections caused by strains of bacteria such as E.coli, Klebsiella...caused: Cystitis, urethritis, pyelonephritis, pyelonephritis, genital infection, postpartum infection, post-partum infection abortion or post-procedural infection prevention. Skin abscesses, boils, infectious dermatitis. Oral infections such as oral mucositis, alveolar abscess, gingivitis,... Bone infections, osteomyelitis. Koact is contraindicated in the following cases:
Allergy to penicillin or other beta-lactam antibiotics. Cross-allergies can occur with cephalosporin antibiotics. Patients with a history of jaundice or those with hepatobiliary dysfunction associated with the use of amoxicillin or clavulanic acid. Patients with severe renal impairment should not use. Avoid use in patients with infectious mononucleosis, because there is a high risk of rash in these patients if Amoxicillin is used.
3. Dosage and how to use Koact
The drug is taken by mouth with water, do not chew or crush the tablet when taking it. Note to increase the tolerance of the drug on the gastrointestinal tract, when used should be taken at the beginning of a meal (on an empty stomach) for the best absorption of the drug.
Dosage of Koact:
Adults and children 12 years of age and older: Mild and moderate infections: 1 tablet/time of Koact 625 and used every 12 hours. Severe infections: 1 tablet / time Koact 625 every 8 hours / time or use 1 tablet Koact 1000 / time and twice a day. Children under 12 years of age and weighing < 25 kg should be treated with the drug in suspension or sachets. Elderly: No dose adjustment is required and can be used as adults. If there are signs of renal impairment, the dose should be adjusted according to the patient's renal impairment. Renal impairment: Adjust dose according to creatinine clearance. It should be noted: The duration of treatment should not exceed 14 days.
4. Possible side effects when taking Koact
Like other drugs, the use of Koact 625 or Koact 1000 can cause side effects including:
Diarrhea, stomach pain, itchy skin are common side effects. Uncommon side effects: Eosinophilia, nausea and vomiting, hepatitis and obstructive jaundice, increased liver enzymes. Rarely may occur: Anaphylactic reactions (difficulty breathing, abdominal pain, urticaria, facial swelling, throat swelling...), Quincke's edema, slight decrease in platelet count, leukopenia, hemolytic anemia, pseudomembranous colitis, Stevens–Johnson syndrome, atopic dermatitis, erythema multiforme, toxic epidermal necrolysis, interstitial nephritis. When seeing rare side effects, the patient should immediately go to the nearest medical facility for timely treatment. In addition, if there are other side effects that affect the use of the drug, you should immediately notify your doctor so that the medicine can be adjusted accordingly.
5. Notes when using the drug Koact
Some things you need to keep in mind when using Koact medicine include:
Pay attention to inform your medical history and allergy history to your doctor before consulting the drug. Adhere to the correct use of the dose and duration of use, do not arbitrarily increase the dose, stop the drug when there are signs of improvement but not enough dose to avoid very dangerous antibiotic resistance. If there are signs of resistance to this antibiotic such as no response when used for more than 2 days, the antibiotic should not be used again. Koact can interact with some other drugs, so when taking it, you need to tell your doctor about the drugs you are taking. Some drugs that have been proven to have the potential to cause interactions with this drug are: Nifedipine, Methotrexate, Allopurinol, anticoagulants, oral contraceptives,... May cause adverse effects on the fetus, therefore should be avoided during pregnancy. Breastfeeding women when taking this drug can also be excreted in breast milk, so when using it, it is necessary to consider to limit the risk of harm to the nursing infant. Store the medicine in a dry place, the temperature is below 30 degrees, away from direct light and out of the reach of small children. Koact is a broad-spectrum antibiotic and can be used for many people when it comes to bacterial infections. However, this is an antibiotic, so it should be used under a doctor's prescription, the patient should not arbitrarily use the drug indiscriminately to avoid the risk of causing harm to the body and antibiotic resistance.
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