The drugs Nifedipine, Botox ® and GTN may improve flow through the sphincter of Oddi and minimize symptoms of sphincter of Oddi disorder, but efficacy remains to be demonstrated in sufficiently large, randomized, and controlled trials. witness. Therefore, endoscopic sphincterotomy remains the treatment of choice for a number of patients correctly diagnosed with sphincter of Oddi disorder.

The etiology of sphincter of Oddi dysfunction is usually due to local scarring secondary to gallstone removal or surgical manipulation or to inflammatory invasion from a nearby duodenal ulcer or suprapapillary pancreatitis. Whether or not primary papillary stenosis is present is controversial although the historical finding of adenitis is likely to be the cause.