Severe acute pancreatitis is an acute inflammation of the pancreas that leads to damage to the follicular cells, causing destruction of pancreatic enzymes to a severe degree and even death. Understanding the cause of severe acute pancreatitis helps patients and treating doctors make an accurate diagnosis to have an appropriate and effective treatment plan.

Severe acute pancreatitis is an acute, rapidly progressive medical disease that causes multi-organ failure and is life-threatening if not treated promptly. Accordingly, this diagnosis requires early detection and active medical and surgical intervention, requiring the participation of a team of professional and experienced doctors as well as adequate means, equipment and machinery to support aid.

Acute pancreatitis is an acute gastrointestinal disease with a poor prognosis. For severe cases of acute pancreatitis, the progression is often rapid, with a high risk of life-threatening. Therefore, early recognition of signs of severe acute pancreatitis helps to guide early diagnosis, timely intervention, and improve prognosis.

Acute pancreatitis is the most common serious complication following ERCP. Early recognition and appropriate management of potential adverse events are essential to reduce associated morbidity and mortality. In particular, the diagnosis of acute pancreatitis after late endoscopic retrograde cholangiopancreatitis can be fatal.

In the early stage of acute pancreatitis (AP), a large number of cytokines produced by local pancreatitis severely damage the intestinal barrier function, intestinal bacteria and endotoxins invade the blood, causing an inflammatory storm, leading to multiple organ failure, infectious complications, and other disorders, eventually leading to death.