Mast cells are responsible for helping protect the body from disease and supporting wound healing by releasing substances such as histamine and leukotrienes. However, for some reason, the number of mast cells in the body is too high, causing disease.

Usually, cases of mast cell disease are urticaria pigmentosa with generalized or solid form and cutaneous mastocytosis with papulo-macular plaques that resolve spontaneously in children and are not dangerous. It is very rare to encounter a form with combined systemic lesions. However, in adults, UP or cutaneous maculopapular telangiectasia is common and there is a risk of developing systemic mastocytosis. The acute form of diffuse degranulation mastocytosis will affect the lives of children due to acute shock.